DK193088A - 2-acylpyrrolidin-derivater, deres fremstilling og anvendelse - Google Patents

2-acylpyrrolidin-derivater, deres fremstilling og anvendelse

Info

Publication number
DK193088A
DK193088A DK193088A DK193088A DK193088A DK 193088 A DK193088 A DK 193088A DK 193088 A DK193088 A DK 193088A DK 193088 A DK193088 A DK 193088A DK 193088 A DK193088 A DK 193088A
Authority
DK
Denmark
Prior art keywords
preparation
acylpyrrolidine derivatives
acylpyrrolidine
derivatives
Prior art date
Application number
DK193088A
Other languages
English (en)
Other versions
DK193088D0 (da
Inventor
Rainer Henning
Franz Hock
Hansjoerg Urbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK193088D0 publication Critical patent/DK193088D0/da
Publication of DK193088A publication Critical patent/DK193088A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK193088A 1987-04-11 1988-04-08 2-acylpyrrolidin-derivater, deres fremstilling og anvendelse DK193088A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712365 DE3712365A1 (de) 1987-04-11 1987-04-11 Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Publications (2)

Publication Number Publication Date
DK193088D0 DK193088D0 (da) 1988-04-08
DK193088A true DK193088A (da) 1988-10-12

Family

ID=6325457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK193088A DK193088A (da) 1987-04-11 1988-04-08 2-acylpyrrolidin-derivater, deres fremstilling og anvendelse

Country Status (14)

Country Link
US (1) US4912127A (da)
EP (1) EP0286928A3 (da)
JP (1) JPS63267755A (da)
KR (1) KR880012543A (da)
AU (1) AU607754B2 (da)
DE (1) DE3712365A1 (da)
DK (1) DK193088A (da)
FI (1) FI881613A (da)
HU (1) HU199784B (da)
IL (1) IL86027A (da)
NO (1) NO881544L (da)
PH (1) PH25713A (da)
PT (1) PT87195B (da)
ZA (1) ZA882459B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3742431A1 (de) * 1987-12-15 1989-07-13 Hoechst Ag Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
JPH0825995B2 (ja) * 1988-04-08 1996-03-13 小野薬品工業株式会社 複素環化合物
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
DE3817468A1 (de) * 1988-05-21 1989-11-30 Hoechst Ag Ethylenisch ungesaettigte harnstoffderivate und verfahren zu ihrer herstellung
US5254696A (en) * 1990-09-13 1993-10-19 Bayer Aktiengesellschaft N-acylpyrrolidine derivatives
DE4029054A1 (de) * 1990-09-13 1992-03-19 Bayer Ag N-acylpyrrolidin-derivate
EP0731788B1 (en) * 1993-12-02 2002-09-11 Merrell Pharmaceuticals Inc. Prolyl endopeptidase inhibitors
DE19527574A1 (de) * 1995-07-28 1997-01-30 Basf Ag Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden
AR038967A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
EP2338490A3 (en) 2003-11-03 2012-06-06 Probiodrug AG Combinations useful for the treatment of neuronal disorders
BRPI0507485A (pt) 2004-02-05 2007-07-10 Probiodrug Ag inibidores novos de glutaminil ciclase
US8524654B2 (en) 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492640A (en) * 1975-07-08 1977-11-23 Ucb Sa L-pyroglutamyl-l-prolinamide
US4560795A (en) * 1979-04-10 1985-12-24 Merrell Dow France et Cie. α-Halomethyl derivatives of α-amino acids
US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
GB2083030B (en) * 1980-08-23 1984-03-07 Merrell Toraude & Co Fluorinated pentene diamine derivatives
US4456594A (en) * 1981-11-06 1984-06-26 Smithkline Beckman Corporation N-Carboxyalkylproline-containing tripeptides
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0655758B2 (ja) * 1984-08-24 1994-07-27 味の素株式会社 アミノ酸誘導体
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
EP0201741B1 (en) * 1985-04-16 1991-07-31 Suntory Limited Dipeptide derivatives, processes for preparing them, pharmaceutical composition and use
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
JPH0653757B2 (ja) * 1985-12-06 1994-07-20 味の素株式会社 プロリン誘導体の芳香族スルホン酸塩
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712363A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Also Published As

Publication number Publication date
ZA882459B (en) 1988-09-29
NO881544L (no) 1988-10-12
HU199784B (en) 1990-03-28
NO881544D0 (no) 1988-04-08
KR880012543A (ko) 1988-11-28
PT87195A (pt) 1988-05-01
AU1446688A (en) 1988-10-13
PH25713A (en) 1991-09-18
FI881613A (fi) 1988-10-12
IL86027A (en) 1992-05-25
HUT46888A (en) 1988-12-28
EP0286928A3 (de) 1991-05-08
JPS63267755A (ja) 1988-11-04
AU607754B2 (en) 1991-03-14
US4912127A (en) 1990-03-27
PT87195B (pt) 1992-07-31
DE3712365A1 (de) 1988-10-27
FI881613A0 (fi) 1988-04-07
EP0286928A2 (de) 1988-10-19
IL86027A0 (en) 1988-09-30
DK193088D0 (da) 1988-04-08

Similar Documents

Publication Publication Date Title
DK609489D0 (da) Imidazolderivater, deres fremstilling og anvendelse
DK374289D0 (da) Indazol-3-carboxylsyrederivater, deres fremstilling og anvendelse
DK605489D0 (da) Beta-amino-boronsyre-derivater, deres fremstilling og anvendelse
DK595388D0 (da) Benzopyranderivater, deres fremstilling og anvendelse
DK193088A (da) 2-acylpyrrolidin-derivater, deres fremstilling og anvendelse
DK633287D0 (da) Carbamoylimidazo-derivater, deres fremstilling og anvendelse
DK278188D0 (da) Thiazolidin-4-on-derivater, deres fremstilling og anvendelse
DK235787A (da) Tripeptidderivater, deres fremstilling og anvendelse
DK189488D0 (da) Imidazothiadiazinderivater, deres fremstilling og anvendelse
DK213387A (da) Benzothiazinon-derivater, deres fremstilling og anvendelse
DK469389D0 (da) Piperidinyl-imidazol-derivater, deres fremstilling og anvendelse
DK212687D0 (da) Benzothiazinon-derivater, deres fremstilling og anvendelse
DK162087D0 (da) Piperidinforbindelser, deres fremstilling og anvendelse
DK223288D0 (da) Benzensulfornamid-derivater, deres fremstilling og anvendelse
DK610787A (da) Substituerede thienoimidazoltoluidin-derivater, deres fremstilling og anvendelse
DK412188D0 (da) Benzothiazinon-derivater, deres fremstilling og anvendelse
DK231988A (da) 2-aminoalkyl-4-benzyl-1-(2h)-phthalazinon-derivater, deres fremstilling og anvendelse
NO885020D0 (no) Isokinolinderivater, deres fremstilling og anvendelse.
DK193288D0 (da) Pyrrolidin-derivater, deres fremstilling og anvendelse
DK361388D0 (da) Cephemderivater, deres fremstilling og anvendelse
DK613888A (da) Acyllabdan-derivater, deres fremstilling og anvendelse
DK668788A (da) Labdanderivater, deres fremstilling og anvendelse
DK668888D0 (da) Labdan-derivater, deres fremstilling og anvendelse
DK727388D0 (da) 2-aminotetrahydroisoquinolinderivater, deres fremstilling og anvendelse
DK163589D0 (da) Sakyomycin e og derivater deraf, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
ATS Application withdrawn