IL85878A - Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodies - Google Patents
Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodiesInfo
- Publication number
- IL85878A IL85878A IL8885878A IL8587888A IL85878A IL 85878 A IL85878 A IL 85878A IL 8885878 A IL8885878 A IL 8885878A IL 8587888 A IL8587888 A IL 8587888A IL 85878 A IL85878 A IL 85878A
- Authority
- IL
- Israel
- Prior art keywords
- proteins
- vac
- antibodies
- monoclunal
- secrete
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873710430 DE3710430A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DE19873710364 DE3710364A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DE19873710309 DE3710309A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DE19873737367 DE3737367A1 (de) | 1987-11-04 | 1987-11-04 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
IL85878A0 IL85878A0 (en) | 1988-09-30 |
IL85878A true IL85878A (en) | 1993-07-08 |
Family
ID=27433878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8885878A IL85878A (en) | 1987-03-28 | 1988-03-27 | Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodies |
Country Status (17)
Country | Link |
---|---|
US (1) | US5837842A (ja) |
EP (1) | EP0293567B1 (ja) |
JP (1) | JPH01503515A (ja) |
KR (1) | KR890700666A (ja) |
AT (1) | ATE133707T1 (ja) |
AU (1) | AU625214B2 (ja) |
DD (1) | DD273285A5 (ja) |
DE (1) | DE3854950D1 (ja) |
DK (1) | DK175468B1 (ja) |
FI (1) | FI103892B (ja) |
HU (1) | HUT52544A (ja) |
IE (2) | IE960853L (ja) |
IL (1) | IL85878A (ja) |
NO (1) | NO885275L (ja) |
NZ (1) | NZ224057A (ja) |
PT (1) | PT87083B (ja) |
WO (1) | WO1988007576A2 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2660514B2 (ja) * | 1987-02-20 | 1997-10-08 | 興和株式会社 | 抗血液凝固作用を有するポリペプチド |
ES2096556T3 (es) * | 1988-02-26 | 1997-03-16 | Biogen Inc | Secuencias de adn, moleculas de adn recombinante y procedimientos para producir lipocortinas iii, iv, v y vi. |
AU3231189A (en) * | 1988-03-31 | 1989-10-05 | Rorer International (Overseas) Inc. | Recombinant endonexin ii |
DE3910240A1 (de) * | 1989-03-30 | 1990-10-04 | Behringwerke Ag | Pp4-delta, seine herstellung und verwendung |
DE59001418D1 (de) * | 1989-07-15 | 1993-06-17 | Boehringer Ingelheim Int | Antikoagulanz enthaltendes mittel. |
DE3937607A1 (de) * | 1989-11-11 | 1991-05-16 | Boehringer Ingelheim Int | Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen |
AU642202B2 (en) * | 1989-12-27 | 1993-10-14 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
US5627036A (en) * | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
EP0538459A4 (en) * | 1991-05-09 | 1993-06-16 | The Board Of Regents Of The University Of Washington | Phospholipid-targeted thrombolytic agents |
US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
ES2146231T3 (es) * | 1992-07-08 | 2000-08-01 | Innogenetics Nv | Polipeptidos derivados de la endonexina 2 y que presentan una actividad de receptor del virus de la hepatitis b, y su utilizacion en composiciones diagnosticas y farmaceuticas. |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
EP0741144B1 (en) * | 1994-11-11 | 2002-07-24 | Noboru Kaneko | Antiannexin-v monoclonal antibody, process for producing the same, and use therof |
US20090291086A1 (en) * | 2001-02-21 | 2009-11-26 | Alavita Pharmaceuticals, Inc. | Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia |
US7635676B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
EP1839670A3 (en) * | 2001-02-21 | 2009-11-11 | Alavita Pharmaceuticals, Inc. | Modified Annexin Proteins and their use against thrombosis |
US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
US20050222030A1 (en) * | 2001-02-21 | 2005-10-06 | Anthony Allison | Modified annexin proteins and methods for preventing thrombosis |
US7645739B2 (en) | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
AU784548B2 (en) * | 2001-03-16 | 2006-04-27 | Ortho-Clinical Diagnostics, Inc. | Reg-like protein |
EP1445613B1 (en) * | 2001-05-21 | 2010-07-07 | FUJIFILM Corporation | Biochemical analysis unit and method for its production |
US7622260B2 (en) | 2001-09-05 | 2009-11-24 | The Brigham And Women's Hospital, Inc. | Diagnostic and prognostic tests |
FR2841558B1 (fr) * | 2002-07-01 | 2004-08-13 | Commissariat Energie Atomique | Peptides marques ayant une affinite pour un phospholipide et utilisations |
FR2841557B1 (fr) * | 2002-07-01 | 2005-12-09 | Commissariat Energie Atomique | Peptides ayant une affinite pour un phospholipide et utilisations |
DE602004020855D1 (de) * | 2003-11-20 | 2009-06-10 | Hoffmann La Roche | Spezifische Marker für Stoffwechselssyndrome |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
FI83882C (fi) * | 1984-09-21 | 1991-09-10 | Boehringer Ingelheim Int | Foerfarande foer framstaellning av blodlevring haemmande proteiner. |
US5066788A (en) * | 1984-09-21 | 1991-11-19 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
AU601676B2 (en) * | 1985-01-10 | 1990-09-20 | Biogen, Inc. | Dna sequences recombinant dna molecules and processes for producing human lipocorton-like polypeptides |
JP2757987B2 (ja) * | 1985-04-15 | 1998-05-25 | バイオテクノロジー リサーチ パートナーズ,リミテッド | ヒト抗‐炎症ホスホリパーゼ阻害蛋白 |
CA1265446A (en) * | 1985-09-30 | 1990-02-06 | Masahiro Maki | Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component |
AU1299788A (en) * | 1987-02-06 | 1988-08-24 | Board Of Regents Of The University Of Washington, The | Human proteins having anticoagulant and anti-inflammatory activity |
US4937324A (en) * | 1987-02-06 | 1990-06-26 | Zymogenetics, Inc. | Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity |
US5179081A (en) * | 1988-07-21 | 1993-01-12 | Kowa Co., Ltd. | Method of treatment using an anticoagulant polypeptide |
-
1988
- 1988-03-25 PT PT87083A patent/PT87083B/pt not_active IP Right Cessation
- 1988-03-26 WO PCT/EP1988/000266 patent/WO1988007576A2/de active IP Right Grant
- 1988-03-26 EP EP88104916A patent/EP0293567B1/de not_active Expired - Lifetime
- 1988-03-26 HU HU882496A patent/HUT52544A/hu unknown
- 1988-03-26 JP JP63503314A patent/JPH01503515A/ja active Pending
- 1988-03-26 DE DE3854950T patent/DE3854950D1/de not_active Expired - Lifetime
- 1988-03-26 AT AT88104916T patent/ATE133707T1/de not_active IP Right Cessation
- 1988-03-27 IL IL8885878A patent/IL85878A/xx not_active IP Right Cessation
- 1988-03-28 IE IE960853A patent/IE960853L/xx unknown
- 1988-03-28 NZ NZ224057A patent/NZ224057A/xx unknown
- 1988-03-28 IE IE92888A patent/IE74679B1/en not_active IP Right Cessation
- 1988-03-28 DD DD31410688A patent/DD273285A5/de not_active IP Right Cessation
- 1988-03-28 AU AU14027/88A patent/AU625214B2/en not_active Expired
- 1988-11-25 NO NO88885275A patent/NO885275L/no unknown
- 1988-11-25 KR KR1019880701535A patent/KR890700666A/ko not_active Application Discontinuation
- 1988-11-25 DK DK198806622A patent/DK175468B1/da not_active IP Right Cessation
- 1988-11-28 FI FI885504A patent/FI103892B/fi not_active IP Right Cessation
-
1995
- 1995-01-23 US US08/376,050 patent/US5837842A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT87083A (pt) | 1988-04-01 |
AU625214B2 (en) | 1992-07-02 |
PT87083B (pt) | 1992-07-31 |
IL85878A0 (en) | 1988-09-30 |
AU1402788A (en) | 1988-09-29 |
JPH01503515A (ja) | 1989-11-30 |
FI885504A (fi) | 1988-11-28 |
FI885504A0 (fi) | 1988-11-28 |
NZ224057A (en) | 1991-04-26 |
WO1988007576A3 (fr) | 1989-01-26 |
WO1988007576A2 (fr) | 1988-10-06 |
US5837842A (en) | 1998-11-17 |
IE74679B1 (en) | 1997-07-30 |
FI103892B1 (fi) | 1999-10-15 |
IE880928L (en) | 1988-09-28 |
DK662288D0 (da) | 1988-11-25 |
NO885275L (no) | 1989-01-25 |
EP0293567A1 (de) | 1988-12-07 |
EP0293567B1 (de) | 1996-01-31 |
HUT52544A (en) | 1990-07-28 |
DE3854950D1 (de) | 1996-03-14 |
DK662288A (da) | 1989-01-25 |
ATE133707T1 (de) | 1996-02-15 |
DD273285A5 (de) | 1989-11-08 |
DK175468B1 (da) | 2004-11-01 |
IE960853L (en) | 1988-09-28 |
NO885275D0 (no) | 1988-11-25 |
KR890700666A (ko) | 1989-11-26 |
FI103892B (fi) | 1999-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RH | Patent void |