IL85646A - Therapeutic composition for the treatment of retroviral infections comprising a retroviral compound and a mismatched dsrna - Google Patents

Therapeutic composition for the treatment of retroviral infections comprising a retroviral compound and a mismatched dsrna

Info

Publication number
IL85646A
IL85646A IL85646A IL8564688A IL85646A IL 85646 A IL85646 A IL 85646A IL 85646 A IL85646 A IL 85646A IL 8564688 A IL8564688 A IL 8564688A IL 85646 A IL85646 A IL 85646A
Authority
IL
Israel
Prior art keywords
retroviral
treatment
therapeutic composition
compound
mismatched dsrna
Prior art date
Application number
IL85646A
Other languages
English (en)
Other versions
IL85646A0 (en
Original Assignee
Hem Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hem Res Inc filed Critical Hem Res Inc
Publication of IL85646A0 publication Critical patent/IL85646A0/xx
Publication of IL85646A publication Critical patent/IL85646A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
IL85646A 1987-03-23 1988-03-07 Therapeutic composition for the treatment of retroviral infections comprising a retroviral compound and a mismatched dsrna IL85646A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2882387A 1987-03-23 1987-03-23
US07/125,097 US4950652A (en) 1987-03-23 1987-11-25 dsRNAs for combination therapy in the treatment of viral diseases

Publications (2)

Publication Number Publication Date
IL85646A0 IL85646A0 (en) 1988-08-31
IL85646A true IL85646A (en) 1993-05-13

Family

ID=26704119

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85646A IL85646A (en) 1987-03-23 1988-03-07 Therapeutic composition for the treatment of retroviral infections comprising a retroviral compound and a mismatched dsrna

Country Status (21)

Country Link
US (1) US4950652A (fi)
EP (1) EP0286224B1 (fi)
JP (1) JP2656938B2 (fi)
KR (1) KR960013435B1 (fi)
CN (1) CN1049357C (fi)
AU (1) AU1256288A (fi)
CA (1) CA1316832C (fi)
DE (1) DE3876125T2 (fi)
DK (1) DK156688A (fi)
ES (1) ES2066782T3 (fi)
FI (1) FI881305A (fi)
GR (1) GR3006340T3 (fi)
HU (1) HUT46542A (fi)
IE (1) IE63823B1 (fi)
IL (1) IL85646A (fi)
NO (1) NO881246L (fi)
NZ (1) NZ223868A (fi)
OA (1) OA08724A (fi)
PH (1) PH23333A (fi)
PT (1) PT87039B (fi)
RU (1) RU2016572C1 (fi)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6130206A (en) * 1980-07-07 2000-10-10 Hem Research, Inc. Treating viral infections associated with chronic fatigue with dsRNA
US9309574B1 (en) 1984-08-22 2016-04-12 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Molecular cloning of HIV-1 from immortalized cell lines
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function
US5906980A (en) * 1987-07-17 1999-05-25 Hem Research Inc. Treatment of hepatitis with mismatched dsRNA
US5712257A (en) * 1987-08-12 1998-01-27 Hem Research, Inc. Topically active compositions of mismatched dsRNAs
US4963532A (en) * 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
US4960592A (en) * 1989-04-17 1990-10-02 Lanocare Laboratories Lanolin and lanolin oil skin treatment composition
US5132292A (en) * 1990-05-25 1992-07-21 Hem Research, Inc. Treatment of viral hepatitis
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US6703418B2 (en) * 1991-02-26 2004-03-09 Unimed Pharmaceuticals, Inc. Appetite stimulation and induction of weight gain in patients suffering from symptomatic HIV infection
JPH06507624A (ja) * 1991-04-16 1994-09-01 ヘム・ファーマスーティカル・コーポレーション ヌクレオシド類似体に対するウイルスの耐性の２本鎖ｒｎａによる抑制法
GB9108085D0 (en) * 1991-04-16 1991-06-05 Scras Complexes of polyadenylic acid with polyuridylic acid
WO1993001717A1 (en) * 1991-07-16 1993-02-04 Hem Pharmaceuticals Corp. Modulation and diagnosis of cytokine dysfunctions
US20030207813A1 (en) * 1996-12-09 2003-11-06 G.D. Searle Retroviral protease inhibitor combinations
WO1996040191A1 (en) 1995-06-07 1996-12-19 Trimeris, Inc. The treatment of hiv and other viral infections using combinatory therapy
US5834443A (en) * 1996-05-21 1998-11-10 Masiello; Domenick J. Composition and method for treating herpes simplex
GB9622681D0 (en) * 1996-10-31 1997-01-08 Glaxo Group Ltd Pharmaceutical compositions
JP2002515892A (ja) * 1997-01-17 2002-05-28 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド サイトカインが関係する疾患治療法
LT4475B (lt) * 1997-02-28 1999-02-25 Virmantas Stunžėnas Informacinės ribonukleino rūgšties panaudojimas vaistinėse medžiagose, skirtose padidinti šios ribonukleino rūgšties koduojamo baltymo kiekį paciento ląstelėse
FR2766711B1 (fr) * 1997-08-04 2001-02-02 Sod Conseils Rech Applic Produit comprenant au moins un arn double brin en association avec au moins un devire du 6-benzyluracile pour une utilisation therapeutique simultanee, separee ou etalee dans le temps
TW589189B (en) 1997-08-04 2004-06-01 Scras Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
FR2768344B1 (fr) * 1997-08-26 2001-02-16 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale
FR2766715B1 (fr) * 1997-08-04 2001-02-16 Scras Produit comprenant au moins de l'arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique simultanee, separee ou etalee dans le temps, dans le traitement d'une maladie virale
FR2768345B1 (fr) * 1997-09-17 2001-05-04 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale, notamment d'une hepatite virale
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
KR20010042069A (ko) 1998-03-20 2001-05-25 베니텍 오스트레일리아 리미티드 유전자 발현 조절방법
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US20080242627A1 (en) * 2000-08-02 2008-10-02 University Of Southern California Novel rna interference methods using dna-rna duplex constructs
DE10100588A1 (de) * 2001-01-09 2002-07-18 Ribopharma Ag Verfahren zur Hemmung der Expression eines Zielgens
CA2369944A1 (en) 2001-01-31 2002-07-31 Nucleonics Inc. Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
AU2002364163A1 (en) * 2001-12-14 2003-06-30 Hemispherx Biopharma USE OF dsRNAs IN STRATEGIC THERAPEUTIC INTERVENTION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
WO2003054161A2 (en) 2001-12-20 2003-07-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
CA2475003A1 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Double-stranded oligonucleotides
US8153141B2 (en) 2002-04-04 2012-04-10 Coley Pharmaceutical Gmbh Immunostimulatory G, U-containing oligoribonucleotides
US8263091B2 (en) 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
US20050137154A1 (en) * 2003-05-16 2005-06-23 Hemispherx Biopharma Treating server acute respiratory syndrome
US20060035859A1 (en) * 2003-05-16 2006-02-16 Hemispherx Biopharma Treating severe and acute viral infections
WO2005007831A2 (en) * 2003-07-18 2005-01-27 Vanderbilt University Compositions of protein mimetics and methods of using same against hiv-1, sars-cov and the like
CN103446582A (zh) * 2003-08-11 2013-12-18 财团法人阪大微生物病研究会 包含诱导粘膜免疫的佐剂的新型疫苗
RU2272631C2 (ru) * 2004-04-20 2006-03-27 Государственный научный центр вирусологии и биотехнологии "Вектор" (ГНЦ ВБ "Вектор") Синергическая композиция для ингибирования вич
DE202005004135U1 (de) * 2005-03-11 2005-05-19 Klocke Verpackungs-Service Gmbh Mehrkomponentenverpackung mit Applikator
EP2883957A1 (en) 2005-11-25 2015-06-17 Zoetis Belgium S.A. Immunostimmulatory oligoribonucleotides
US8075877B2 (en) 2006-03-08 2011-12-13 Hemispherx Biopharma Broad spectrum immune and antiviral gene modulation by oral interferon
CA2644670A1 (en) * 2006-03-08 2008-05-08 Hemispherx Biopharma Inc. Broad spectrum immune and antiviral gene modulation by oral interferon
CN101909625A (zh) * 2007-10-29 2010-12-08 希普拉有限公司 新型抗逆转录病毒组合
CN101990435A (zh) * 2008-02-15 2011-03-23 海米斯费克斯生物制药公司 Toll样受体3的选择性激动剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113162B1 (en) * 1982-09-16 1989-07-19 Hem Research, Inc. Anti-proliferative action of dsnras on tumor cells
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
ATE113603T1 (de) * 1985-03-16 1994-11-15 Wellcome Found Antivirale nukleoside.
US4795744A (en) * 1986-07-17 1989-01-03 Hem Research, Inc. Modulation of AIDS virus-related events by double-stranded RNAS
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)

Also Published As

Publication number Publication date
DK156688D0 (da) 1988-03-22
CA1316832C (en) 1993-04-27
JPS6425A (en) 1989-01-05
GR3006340T3 (fi) 1993-06-21
PT87039A (pt) 1988-04-01
KR880010777A (ko) 1988-10-24
DK156688A (da) 1988-09-24
EP0286224B1 (en) 1992-11-25
FI881305A0 (fi) 1988-03-18
KR960013435B1 (ko) 1996-10-05
FI881305A (fi) 1988-09-24
IL85646A0 (en) 1988-08-31
NZ223868A (en) 1991-02-26
DE3876125T2 (de) 1993-06-09
PT87039B (pt) 1992-11-30
EP0286224A2 (en) 1988-10-12
EP0286224A3 (en) 1988-12-07
OA08724A (fr) 1989-03-31
NO881246D0 (no) 1988-03-21
CN1049357C (zh) 2000-02-16
JP2656938B2 (ja) 1997-09-24
US4950652A (en) 1990-08-21
DE3876125D1 (de) 1993-01-07
NO881246L (no) 1988-09-26
AU1256288A (en) 1988-09-22
PH23333A (en) 1989-07-14
ES2066782T3 (es) 1995-03-16
IE880839L (en) 1988-09-23
CN88101606A (zh) 1988-12-28
IE63823B1 (en) 1995-06-14
RU2016572C1 (ru) 1994-07-30
HUT46542A (en) 1988-11-28

Similar Documents

Publication Publication Date Title
IL85646A (en) Therapeutic composition for the treatment of retroviral infections comprising a retroviral compound and a mismatched dsrna
GB2204237B (en) Agents for the prophylaxis and therapy of retroviral infections
GB8812914D0 (en) Treatment of materials
GB2231272B (en) Improved bandage
GB8706022D0 (en) Bandages
EP0251434A3 (en) Treatment of fungal infections
IL74469A0 (en) Treatment of cotton
AU1279788A (en) Compounds and treatment
GB2232159B (en) Acidic treatment of gluten
JPS6416773A (en) Manufacture of 2-quinoxalinol compound
AU1541088A (en) Composition for the treatment of the epiderm
GR3000306T3 (en) Composition for the treatment of infections
GB2220652B (en) Treatment of pastures
NO173145C (no) Fremgangsmaate for behandling av voerter
GB8707427D0 (en) Treatment of dandruff
GB8722529D0 (en) Treatment of burns
GB8602813D0 (en) Treatment of flax
ZA882667B (en) Agents for the prophylaxis and therapy of retroviral infections
ZA867888B (en) Composition for the treatment of infections
ZA872553B (en) Treatment of fungal infections
CS618987A1 (en) Treatment of polyesteromelt adhesive
GB8729067D0 (en) Treatment of timber
RO92740B1 (ro) Compozitie medicamentoasa pentru tratamentul otitelor
GB8723743D0 (en) Facilitate correct application of extensible bandage
GB8721773D0 (en) Treatment of fibres

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees