IL85154A - Process for the synthesis of vinblastine and vincristine and related dimer alkaloid compounds - Google Patents

Process for the synthesis of vinblastine and vincristine and related dimer alkaloid compounds

Info

Publication number
IL85154A
IL85154A IL85154A IL8515488A IL85154A IL 85154 A IL85154 A IL 85154A IL 85154 A IL85154 A IL 85154A IL 8515488 A IL8515488 A IL 8515488A IL 85154 A IL85154 A IL 85154A
Authority
IL
Israel
Prior art keywords
vinblastine
vincristine
synthesis
alkaloid compounds
related dimer
Prior art date
Application number
IL85154A
Other languages
English (en)
Other versions
IL85154A0 (en
Inventor
F Kutney James
S L Choi Lewis
Nakano Jun
Tsukamoto Hiroki
A Boulet Camille
Mchugh Michael
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of IL85154A0 publication Critical patent/IL85154A0/xx
Priority to IL8734788A priority Critical patent/IL87347A/en
Publication of IL85154A publication Critical patent/IL85154A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL85154A 1987-01-22 1988-01-21 Process for the synthesis of vinblastine and vincristine and related dimer alkaloid compounds IL85154A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL8734788A IL87347A (en) 1987-08-06 1988-08-04 Process for the synthesis of vinblastine and vincristine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000527897A CA1341261C (en) 1987-01-22 1987-01-22 Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine

Publications (2)

Publication Number Publication Date
IL85154A0 IL85154A0 (en) 1988-06-30
IL85154A true IL85154A (en) 1992-08-18

Family

ID=4134803

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85154A IL85154A (en) 1987-01-22 1988-01-21 Process for the synthesis of vinblastine and vincristine and related dimer alkaloid compounds

Country Status (11)

Country Link
JP (1) JPH0613531B2 (xx)
CA (1) CA1341261C (xx)
CH (1) CH675724A5 (xx)
DE (1) DE3801450C2 (xx)
FR (1) FR2611202A1 (xx)
GB (1) GB2204036B (xx)
IL (1) IL85154A (xx)
IT (1) IT1215751B (xx)
NL (1) NL8800134A (xx)
SE (1) SE467874B (xx)
ZA (1) ZA88408B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
CA1341262C (en) * 1987-08-06 2001-06-26 Camille A. Boulet A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5037977A (en) * 1988-08-11 1991-08-06 Mitsui Petrochemical Industries Ltd. Method for production of dimeric alkaloids
US5432279A (en) * 1989-03-04 1995-07-11 Mitsui Petrochemical Industries, Inc. Process for the preparation of binary indole alkaloids
HU209687B (en) * 1989-03-04 1994-10-28 Mitsui Petrochemical Ind Process for producing bisz-indole-alkaloids
FR2779146B1 (fr) * 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
CN103936769B (zh) * 2014-04-30 2016-10-05 淮海工学院 一种制备高光学纯脱水长春碱的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (xx) * 1974-12-30 1978-07-21 Anvar
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
GB1551054A (en) * 1976-03-04 1979-08-22 Atta Ur Rahman Syntheses of vinblastine vincristine and vinrosidine
FR2358412A1 (fr) * 1976-07-13 1978-02-10 Parcor Procede de preparation de la vincamine et d'alcaloides apparentes

Also Published As

Publication number Publication date
IT8819156A0 (it) 1988-01-21
GB8801296D0 (en) 1988-02-17
GB2204036B (en) 1991-03-27
GB2204036A (en) 1988-11-02
FR2611202A1 (fr) 1988-08-26
IL85154A0 (en) 1988-06-30
JPH0613531B2 (ja) 1994-02-23
SE8800170L (sv) 1988-07-23
CA1341261C (en) 2001-06-26
SE8800170D0 (sv) 1988-01-20
FR2611202B1 (xx) 1994-08-19
CH675724A5 (xx) 1990-10-31
JPH01131187A (ja) 1989-05-24
DE3801450C2 (de) 1999-02-25
NL8800134A (nl) 1988-08-16
ZA88408B (en) 1989-04-26
IT1215751B (it) 1990-02-22
SE467874B (sv) 1992-09-28
DE3801450A1 (de) 1988-08-18

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees