IL84894A0 - Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives - Google Patents

Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives

Info

Publication number
IL84894A0
IL84894A0 IL84894A IL8489487A IL84894A0 IL 84894 A0 IL84894 A0 IL 84894A0 IL 84894 A IL84894 A IL 84894A IL 8489487 A IL8489487 A IL 8489487A IL 84894 A0 IL84894 A0 IL 84894A0
Authority
IL
Israel
Prior art keywords
derivatives
resolution
optically active
active derivative
dihydropyridine
Prior art date
Application number
IL84894A
Other languages
English (en)
Original Assignee
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Lab filed Critical Syntex Lab
Publication of IL84894A0 publication Critical patent/IL84894A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL84894A 1986-12-22 1987-12-21 Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives IL84894A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/945,760 US4920225A (en) 1986-12-22 1986-12-22 Resolution of 1,4-dihydropyridine derivatives

Publications (1)

Publication Number Publication Date
IL84894A0 true IL84894A0 (en) 1988-06-30

Family

ID=25483522

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84894A IL84894A0 (en) 1986-12-22 1987-12-21 Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives

Country Status (13)

Country Link
US (1) US4920225A (da)
EP (1) EP0273349A3 (da)
JP (1) JPS63185960A (da)
KR (1) KR880007469A (da)
AU (1) AU8284887A (da)
DK (1) DK674287A (da)
FI (1) FI875623A (da)
GB (1) GB2200631A (da)
HU (1) HUT45499A (da)
IE (1) IE873469L (da)
IL (1) IL84894A0 (da)
NO (1) NO875239L (da)
ZA (1) ZA879579B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737340A1 (de) * 1987-11-04 1989-05-24 Bayer Ag Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8804630D0 (en) * 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
IT1230752B (it) * 1989-02-17 1991-10-29 Boehringer Biochemia Srl Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.
CA2016707A1 (en) * 1989-05-15 1990-11-15 Graham A. Showell Process for resolving 1-azabicyclo[2.2.1]heptane-3-carboxylates
JPH03141257A (ja) * 1989-10-26 1991-06-17 Green Cross Corp:The ジヒドロピリジン誘導体
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
US5210398A (en) * 1991-06-14 1993-05-11 Symbol Technologies, Inc. Optical scanner with extended depth of focus
FR2719585B1 (fr) * 1994-05-05 1996-08-02 Lafon Labor Procédé d'obtention de 1,4-dihydropyridines optiquement pures.
EP1191022A4 (en) * 1999-06-23 2002-09-18 Ajinomoto Kk NEW DIHYDROPYRIDINE DERIVATIVES
AU2001294532A1 (en) * 2000-10-13 2002-04-29 Eli Lilly And Company Resolution process for preparation of substantially pure (r) and (s) enantiomersof 2-(4-nitroimidazolyl)-4-methoxyphenylpropionic acid and salts thereof
JP2007510728A (ja) * 2003-11-03 2007-04-26 ミオゲン インコーポレイティッド 心血管疾患を治療するための１，４−ジヒドロピリジン化合物、薬学的組成物、および方法
DE602004016547D1 (de) 2003-11-03 2008-10-23 Myogen Inc 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370334A (en) * 1975-07-02 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydro-pyridine derivatives and methods of using same
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
SE442298B (sv) * 1978-06-30 1985-12-16 Haessle Ab 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-metylester-5-etylester i optisk aktiv form
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
JPS58208271A (ja) * 1982-04-30 1983-12-03 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59161392A (ja) * 1983-03-04 1984-09-12 Nippon Shinyaku Co Ltd ジヒドロピリジン誘導体及びその製法
EP0141222B1 (en) * 1983-09-26 1989-04-12 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic ester
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives

Also Published As

Publication number Publication date
KR880007469A (ko) 1988-08-27
US4920225A (en) 1990-04-24
FI875623A (fi) 1988-06-23
JPS63185960A (ja) 1988-08-01
GB2200631A (en) 1988-08-10
GB8729735D0 (en) 1988-02-03
IE873469L (en) 1988-06-22
HUT45499A (en) 1988-07-28
DK674287A (da) 1988-06-23
FI875623A0 (fi) 1987-12-21
AU8284887A (en) 1988-06-23
DK674287D0 (da) 1987-12-21
ZA879579B (en) 1989-08-30
EP0273349A3 (en) 1990-02-14
NO875239L (no) 1988-06-23
EP0273349A2 (en) 1988-07-06
NO875239D0 (no) 1987-12-15

Similar Documents

Publication Publication Date Title
IL84894A0 (en) Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives
DK47787D0 (da) Dihydropyridinderivatholdige retardpraeparater
FI894546A (fi) Menetelmä uusien 2'-halogeenimetylideeni-, 2'-etenylideeni- ja 2'-etynyyliadenosiinijohdannaisten valmistamiseksi
NZ218837A (en) Melphalan derivatives and pharmaceutical compositions
EG18453A (en) Five membered heterocyclic derivatives of n'-substituted-n,n'-diacylhidrazines
NZ225303A (en) 2,5 dialkyl-3-phenyl piperidine derivatives and pharmaceutical compositions
DK10190D0 (da) 1,1-dioxo-cephem-4-carbothiolsyrederivater
DK702688D0 (da) Epipodophyllotoxin-glucosid 4'-acylderivater
IL92350A0 (en) Pyrrolidone-2-carboxylic acid derivatives having psychotropic action
IL89536A0 (en) Preparation of 1,4-dihydropyridine derivatives
DK587689A (da) 2-azabicyclo(2,2,1)hept-5-en-2-eddikesyre og derivater deraf, deres fremstilling og anvendelse
EP0371492A3 (en) Process for the preparation of 1,4-dihydropyridine derivatives
HU9202873D0 (en) 1,4-dihydropyridine derivatives of paf-antagonistic effect
AU6984987A (en) Substituted 1,4-dihydropyridine ester derivatives
DK142287A (da) Optisk aktive 1,4-dihydropyridinderivater
GB8724868D0 (en) 2-substituted 1 4-dihydropyridine derivatives
NZ215083A (en) 1,4-dihydropyridine derivatives and pharmaceutical compositions
ZA893479B (en) 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid derivatives and their preparation
FI904673A0 (fi) 2,6-dioksopiperidiinijohdannaisten valmistus
IL88849A0 (en) Preparation of 1,5-benzo-thiazepine derivatives
GB8715219D0 (en) 1 4-dihydropyridine derivatives
FR2603282B1 (fr) Derives d'isoquinoleine
MC1816A1 (fr) Derives d'isoquinoleine
EP0258815A3 (en) Derivatives of 2,2-dimethyl-cyclopropanecarboxylic acid derivatives of 2,2-dimethyl-cyclopropanecarboxylic acid
ZA876223B (en) Derivatives of 2,2-dimethyl-cyclopropanecarboxylic acid