ZA879579B - Pharmaceutical delivery systems resolution of 1,4-dihydropyridine derivatives - Google Patents

Pharmaceutical delivery systems resolution of 1,4-dihydropyridine derivatives

Info

Publication number
ZA879579B
ZA879579B ZA879579A ZA879579A ZA879579B ZA 879579 B ZA879579 B ZA 879579B ZA 879579 A ZA879579 A ZA 879579A ZA 879579 A ZA879579 A ZA 879579A ZA 879579 B ZA879579 B ZA 879579B
Authority
ZA
South Africa
Prior art keywords
delivery systems
pharmaceutical delivery
dihydropyridine derivatives
resolution
systems resolution
Prior art date
Application number
ZA879579A
Other languages
English (en)
Inventor
Michael John Story
John Story Michael
Michael John Flynn
John Flynn Michael
Cilles Genain
Genain Cilles
Original Assignee
Cortecs Ltd
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortecs Ltd, Syntex Lab filed Critical Cortecs Ltd
Publication of ZA879579B publication Critical patent/ZA879579B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA879579A 1986-12-22 1987-12-17 Pharmaceutical delivery systems resolution of 1,4-dihydropyridine derivatives ZA879579B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/945,760 US4920225A (en) 1986-12-22 1986-12-22 Resolution of 1,4-dihydropyridine derivatives

Publications (1)

Publication Number Publication Date
ZA879579B true ZA879579B (en) 1989-08-30

Family

ID=25483522

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879579A ZA879579B (en) 1986-12-22 1987-12-17 Pharmaceutical delivery systems resolution of 1,4-dihydropyridine derivatives

Country Status (13)

Country Link
US (1) US4920225A (xx)
EP (1) EP0273349A3 (xx)
JP (1) JPS63185960A (xx)
KR (1) KR880007469A (xx)
AU (1) AU8284887A (xx)
DK (1) DK674287A (xx)
FI (1) FI875623A (xx)
GB (1) GB2200631A (xx)
HU (1) HUT45499A (xx)
IE (1) IE873469L (xx)
IL (1) IL84894A0 (xx)
NO (1) NO875239L (xx)
ZA (1) ZA879579B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737340A1 (de) * 1987-11-04 1989-05-24 Bayer Ag Neue fluormethoxyphenyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8804630D0 (en) * 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
IT1230752B (it) * 1989-02-17 1991-10-29 Boehringer Biochemia Srl Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.
EP0398617A3 (en) * 1989-05-15 1991-11-06 Merck Sharp & Dohme Ltd. Process for resolving 1-azabicyclo [2.2.1]heptane-3-carboxylates
JPH03141257A (ja) * 1989-10-26 1991-06-17 Green Cross Corp:The ジヒドロピリジン誘導体
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
US5210398A (en) * 1991-06-14 1993-05-11 Symbol Technologies, Inc. Optical scanner with extended depth of focus
FR2719585B1 (fr) * 1994-05-05 1996-08-02 Lafon Labor Procédé d'obtention de 1,4-dihydropyridines optiquement pures.
EP1191022A4 (en) 1999-06-23 2002-09-18 Ajinomoto Kk NEW DIHYDROPYRIDINE DERIVATIVES
US20040106665A1 (en) * 2000-10-13 2004-06-03 Kress Thomas Joseph Resolution process for preparation of substantially pure (r) and (s) enantiomers of 2-(4-nitroimidazolyl)-4-methodxyphenylpropionic acid and salts thereof
CA2544772A1 (en) * 2003-11-03 2005-05-12 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
EP1685107B1 (en) * 2003-11-03 2008-09-10 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370334A (en) * 1975-07-02 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydro-pyridine derivatives and methods of using same
SE442298B (sv) * 1978-06-30 1985-12-16 Haessle Ab 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-metylester-5-etylester i optisk aktiv form
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
JPS58208271A (ja) * 1982-04-30 1983-12-03 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59161392A (ja) * 1983-03-04 1984-09-12 Nippon Shinyaku Co Ltd ジヒドロピリジン誘導体及びその製法
CA1339372C (en) * 1983-09-26 1997-08-26 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic ester
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives

Also Published As

Publication number Publication date
KR880007469A (ko) 1988-08-27
NO875239D0 (no) 1987-12-15
HUT45499A (en) 1988-07-28
NO875239L (no) 1988-06-23
EP0273349A2 (en) 1988-07-06
FI875623A (fi) 1988-06-23
IE873469L (en) 1988-06-22
IL84894A0 (en) 1988-06-30
DK674287A (da) 1988-06-23
US4920225A (en) 1990-04-24
GB2200631A (en) 1988-08-10
GB8729735D0 (en) 1988-02-03
DK674287D0 (da) 1987-12-21
AU8284887A (en) 1988-06-23
EP0273349A3 (en) 1990-02-14
JPS63185960A (ja) 1988-08-01
FI875623A0 (fi) 1987-12-21

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