IL78553A - Therapeutic compositions of phosphonylmethoxyalkyl adenines - Google Patents

Therapeutic compositions of phosphonylmethoxyalkyl adenines

Info

Publication number
IL78553A
IL78553A IL78553A IL7855386A IL78553A IL 78553 A IL78553 A IL 78553A IL 78553 A IL78553 A IL 78553A IL 7855386 A IL7855386 A IL 7855386A IL 78553 A IL78553 A IL 78553A
Authority
IL
Israel
Prior art keywords
phosphonylmethoxyalkyl
adenines
therapeutic compositions
salts
human
Prior art date
Application number
IL78553A
Other languages
English (en)
Other versions
IL78553A0 (en
Original Assignee
Stichting Rega V Z W
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W, Ceskoslovenska Akademie Ved filed Critical Stichting Rega V Z W
Publication of IL78553A0 publication Critical patent/IL78553A0/xx
Publication of IL78553A publication Critical patent/IL78553A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IL78553A 1985-04-25 1986-04-21 Therapeutic compositions of phosphonylmethoxyalkyl adenines IL78553A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS853018A CS263952B1 (en) 1985-04-25 1985-04-25 Remedy with antiviral effect

Publications (2)

Publication Number Publication Date
IL78553A0 IL78553A0 (en) 1986-08-31
IL78553A true IL78553A (en) 1989-09-28

Family

ID=5369042

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78553A IL78553A (en) 1985-04-25 1986-04-21 Therapeutic compositions of phosphonylmethoxyalkyl adenines

Country Status (17)

Country Link
US (1) US4724233A (cs)
EP (1) EP0205826B1 (cs)
JP (1) JPH0692307B2 (cs)
AT (1) ATE73663T1 (cs)
AU (1) AU586860B2 (cs)
CA (1) CA1272956A (cs)
CS (1) CS263952B1 (cs)
DE (1) DE3684363D1 (cs)
DK (1) DK167342B1 (cs)
EG (1) EG18436A (cs)
GR (1) GR861089B (cs)
HK (1) HK217296A (cs)
IL (1) IL78553A (cs)
NZ (1) NZ215939A (cs)
PH (1) PH23112A (cs)
PT (1) PT82457B (cs)
ZA (1) ZA863133B (cs)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
JP3497505B2 (ja) * 1991-10-11 2004-02-16 インスティテュート オブ オルガニック ケミストリー アンド バイオケミストリー オブ ザ アカデミー オブ サイエンシズ オブ ザ チェコ パブリック 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
WO1995007919A1 (en) * 1993-09-17 1995-03-23 Gilead Sciences, Inc. Method for dosing therapeutic compounds
NZ283658A (en) * 1994-04-04 1999-09-29 William R Freeman Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides)
US5468752A (en) * 1994-04-04 1995-11-21 Freeman; William R. Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
US6635278B1 (en) 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
DE60118521T2 (de) * 2000-01-07 2006-10-12 Universitaire Instelling Antwerpen Purin derivate, ihre herstellung und verwendung
CN1291994C (zh) 2000-07-21 2006-12-27 吉里德科学公司 核苷酸膦酸酯类似物前药及其筛选和制备方法
MXPA04000138A (es) 2001-06-29 2005-06-06 Acad Of Science Czech Republic Compuestos novedosos y metodos de trabajo.
NZ536328A (en) * 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
AU2003235501A1 (en) * 2002-05-13 2003-11-11 Metabasis Therapeutics, Inc. PMEA and PMPA cyclic producing synthesis
RU2225223C1 (ru) * 2002-06-14 2004-03-10 Закрытое акционерное общество Фирма "ВИТАФАРМА" Лиофилизированная антигерпетическая вакцина
KR20050086519A (ko) * 2002-11-12 2005-08-30 티안진 킨슬리 파마슈티컬 컴퍼니 리미티드 새로운 결정 형태를 가진 아데포비어 디피복실 및 그조성물
EA015145B1 (ru) 2003-01-14 2011-06-30 Джилид Сайэнс, Инк. Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
AU2004247305B2 (en) 2003-06-16 2010-02-18 Institute Of Organic Chemistry And Biochemistry, Academy Of Sciences Of The Czech Republic Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
MXPA06014013A (es) * 2004-06-08 2007-03-15 Metabasis Therapeutics Inc Sintesis mediada por acidos de lewis de esteres ciclicos.
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9－[2－(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
EP1778251B1 (en) 2004-07-27 2011-04-13 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
AU2008265397C1 (en) 2007-06-18 2013-08-29 Sunshine Lake Pharma Co., Ltd. Bromo-phenyl substituted thiazolyl dihydropyrimidines
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AU2009333559B2 (en) 2008-12-09 2015-03-12 Gilead Sciences, Inc. Modulators of toll-like receptors
US9169257B2 (en) 2009-03-26 2015-10-27 Daewoong Pharmaceutical Co., Ltd. Crystal forms of adefovir dipivoxil and processes for preparing the same
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
RU2606845C2 (ru) 2010-12-10 2017-01-10 СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
SMT201800538T1 (it) 2013-03-15 2019-01-11 Univ California Diesteri di fosfonato nucleosidico aciclico
WO2015038421A1 (en) 2013-09-10 2015-03-19 Dow Corning Corporation Wear-resistant silicon eutectic alloy components and methods of making the same
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
WO2015195538A1 (en) 2014-06-17 2015-12-23 Dow Corning Corporation Decorative shape-cast articles made from silicon eutectic alloys, and methods for producing the same
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
TWI733652B (zh) 2014-07-11 2021-07-21 美商基利科學股份有限公司 用於治療ＨＩＶ之ｔｏｌｌ樣受體調節劑
HRP20220651T1 (hr) 2014-09-15 2022-08-19 The Regents Of The University Of California Nukleotidni analozi
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
JP2018527366A (ja) 2015-09-15 2018-09-20 ギリアード サイエンシーズ， インコーポレイテッド ＨＩＶを処置するためのｔｏｌｌ様レセプターのモジュレーター
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
JP2025526212A (ja) 2022-07-21 2025-08-13 アンティバ バイオサイエンシズ インコーポレイテッド Ｈｐｖ感染症及びｈｐｖ誘発性新生物の治療用の組成物及び剤形

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS52105195A (en) * 1976-03-01 1977-09-03 Wellcome Found Substituted purine
US4230708A (en) * 1977-10-20 1980-10-28 Stichting Rega V.Z.W. Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS238038B1 (en) * 1983-10-07 1985-11-13 Antonin Holy Medical drug with antivirus effect

Also Published As

Publication number Publication date
EP0205826A3 (en) 1989-05-10
HK217296A (en) 1996-12-27
DK167342B1 (da) 1993-10-18
GR861089B (en) 1986-08-26
PT82457A (en) 1986-05-01
AU5646886A (en) 1986-10-30
JPH0692307B2 (ja) 1994-11-16
ATE73663T1 (de) 1992-04-15
EP0205826B1 (en) 1992-03-18
EG18436A (en) 1993-02-28
JPS61275218A (ja) 1986-12-05
DK184186A (da) 1986-10-26
EP0205826A2 (en) 1986-12-30
ZA863133B (en) 1987-02-25
AU586860B2 (en) 1989-07-27
PH23112A (en) 1989-04-19
DK184186D0 (da) 1986-04-22
CS263952B1 (en) 1989-05-12
CA1272956A (en) 1990-08-21
DE3684363D1 (de) 1992-04-23
PT82457B (pt) 1988-03-03
US4724233A (en) 1988-02-09
NZ215939A (en) 1988-09-29
IL78553A0 (en) 1986-08-31

Similar Documents

Publication Publication Date Title
EG18436A (en) Therapeutical application of phosponylmethoxy-alkyl adenines
NZ252871A (en) Use of consensus human leukocyte interferon (ifn-con) to prepare medicaments for treating viral diseases
IT8419266A1 (it) Dispositivo per generare calore in tessuti" del corpo umano e procedimento di cenerazione di calore, particolarmente per la cura di tumori
MY104575A (en) Therapeutic nucleosides.
FI862011A0 (fi) Terapeutiska nukleosider.
DE68912155D1 (de) Antivirales Kombinationspräparat.
IT1199972B (it) Composizioni farmaceutiche per la terapia di sindromi cerebrali involutive e del decadimento mentale
ZA895840B (en) N-2,3-butadienyl tri-and tetraaminoalkane derivatives
FR2510889B1 (fr) Medicament contenant certains phosphates ribofurannosyl-3',5'-cycliques substitues en 6, 8 pour le traitement de maladies proliferatives de la peau
NO931413L (no) Fremgangsmaater og preparater for behandling av celleproliferasjonssykdommer
IT8721115A0 (it) Fitopreparato per la cura di affezioni cutanee.
EP0180737A3 (en) Use of preparations containing gamma-interferon (ifn-gamma) for treating rheumatic diseases
EP0158880A3 (en) Liposomes with inhalable allergens for treatment of allergies, method for their preparation and pharmaceutical compositions containing them
GEP20012489B (en) Use of Natural Human α-Interferon
DE3462891D1 (en) New pyrimidine derivatives endowed with antiviral activity
ES2103811T3 (es) Terapia antiviral.
ZA887181B (en) A method for the preparation of a pharmaceutical curative for the veterinary and humane medicine,with antiviral and antitumoral effect
ATE136776T1 (de) Verwendung von heptastigmin zur behandlung der zerebralen ictus
SU1565027A1 (ru) Инактиватор вируса западного нила

Legal Events

Date Code Title Description
KB Patent renewed
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
EXP Patent expired