IL78059A - N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them - Google Patents
N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL78059A IL78059A IL78059A IL7805986A IL78059A IL 78059 A IL78059 A IL 78059A IL 78059 A IL78059 A IL 78059A IL 7805986 A IL7805986 A IL 7805986A IL 78059 A IL78059 A IL 78059A
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidin
- amino
- glutamic acid
- alkyl
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL82249A IL82249A (en) | 1986-03-06 | 1987-04-17 | Diastereoisomers of n-(4-(2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido(2,3-d)-pyrimidin-6-yl)ethyl)-benzoyl-l-glutamic acid and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70962285A | 1985-03-08 | 1985-03-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL78059A0 IL78059A0 (en) | 1986-07-31 |
IL78059A true IL78059A (en) | 1989-06-30 |
Family
ID=24850641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL78059A IL78059A (en) | 1985-03-08 | 1986-03-06 | N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0215063B1 (es) |
JP (2) | JPH0822860B2 (es) |
KR (1) | KR940002952B1 (es) |
CN (1) | CN1016174B (es) |
AT (1) | ATE96790T1 (es) |
AU (1) | AU578813B2 (es) |
CA (1) | CA1276637C (es) |
DE (1) | DE3689250T2 (es) |
DK (1) | DK168666B1 (es) |
EG (1) | EG18371A (es) |
ES (2) | ES8704167A1 (es) |
GR (1) | GR860592B (es) |
HU (1) | HU196202B (es) |
IE (1) | IE63653B1 (es) |
IL (1) | IL78059A (es) |
MX (1) | MX9203357A (es) |
NZ (1) | NZ215404A (es) |
PH (1) | PH23136A (es) |
PT (1) | PT82149B (es) |
SU (1) | SU1676449A3 (es) |
WO (1) | WO1986005181A1 (es) |
ZA (1) | ZA861235B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
IE60038B1 (en) * | 1986-06-30 | 1994-05-18 | Univ Princeton | 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives |
US4818819A (en) * | 1986-10-20 | 1989-04-04 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
GB8702758D0 (en) * | 1987-02-06 | 1987-03-11 | Wellcome Found | Treatment of disease |
EP0278686A1 (en) * | 1987-02-07 | 1988-08-17 | The Wellcome Foundation Limited | Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof |
EP0305667A3 (en) * | 1987-09-03 | 1989-10-25 | American Cyanamid Company | Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid |
US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
US4889859A (en) * | 1988-02-05 | 1989-12-26 | The Trustees Of Princeton University | Pyrido[2,3-d]pyrimidine derivatives |
DK172753B1 (da) * | 1988-05-25 | 1999-06-28 | Lilly Co Eli | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ[2,3―d]ピリミジン誘導体,その製造法,用途及び中間体 |
CA2066898A1 (en) * | 1991-04-29 | 1992-10-30 | Chuan Shih | Pharmaceutical compounds |
WO1993022312A1 (en) * | 1992-04-29 | 1993-11-11 | Sri International | Deazaaminopterins for treatment of inflammation |
US5196424A (en) * | 1992-03-24 | 1993-03-23 | Eli Lilly And Company | N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids |
WO1993020075A1 (en) * | 1992-04-01 | 1993-10-14 | The University Of Sydney | 8-substituted-n5-deazapterins as antifolates |
ZA932731B (en) * | 1992-04-23 | 1994-10-19 | Lilly Co Eli | Method of treating gar-transformylase-dependent tumors |
US5594139A (en) * | 1993-01-29 | 1997-01-14 | Agouron Pharmaceuticals, Inc. | Processes for preparing antiproliferative garft-inhibiting compounds |
EP0681584B1 (en) * | 1993-01-29 | 2001-06-06 | Agouron Pharmaceuticals, Inc. | Condensed heterocyclic glutamic acid derivatives as antiproliferative agents |
JP3473956B2 (ja) * | 1994-07-28 | 2003-12-08 | アグーロン ファーマシューティカルズ,インコーポレーテッド | 抗増殖剤およびgarft阻害剤として有用な化合物 |
CN1053448C (zh) * | 1994-07-28 | 2000-06-14 | 阿格罗尼制药公司 | 用作抗增殖药物及garft抑制剂的化合物 |
US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
AU761544C (en) | 1999-05-24 | 2004-02-12 | Sankyo Company Limited | Medicinal compositions containing anti-Fas antibody |
JP5675619B2 (ja) | 2008-09-17 | 2015-02-25 | エンドサイト, インク.Endocyte, Inc. | 葉酸拮抗薬の葉酸受容体結合性コンジュゲート |
CN116333411B (zh) * | 2023-05-29 | 2023-08-11 | 石家庄启宏新材料制品有限公司 | 一种阻燃eva保温材料及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4512992A (en) * | 1980-06-13 | 1985-04-23 | Burroughs Wellcome Co. | Treatment with dialkoxy pyridopyrimidine compounds |
US4431805A (en) * | 1981-09-25 | 1984-02-14 | Southern Research Institute | Pyrido[2,3-d]-pyrimidines |
US4526964A (en) * | 1982-01-11 | 1985-07-02 | Southern Research Institute | 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine |
US4536575A (en) * | 1982-01-11 | 1985-08-20 | Southern Research Institute | 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino |
US4460591A (en) * | 1982-08-26 | 1984-07-17 | Sri International | 8,10-Dideazaminopterins |
US4532241A (en) * | 1982-08-26 | 1985-07-30 | Sri International | 8,10-Dideazaminopterins |
US4432981A (en) * | 1982-11-05 | 1984-02-21 | Sterling Drug Inc. | 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones |
GB2160525B (en) * | 1983-12-27 | 1987-08-26 | Stanford Res Inst Int | 8,10-dideazaminopterins |
-
1986
- 1986-02-19 ZA ZA861235A patent/ZA861235B/xx unknown
- 1986-02-24 DE DE86901675T patent/DE3689250T2/de not_active Expired - Fee Related
- 1986-02-24 JP JP61501296A patent/JPH0822860B2/ja not_active Expired - Fee Related
- 1986-02-24 AU AU55108/86A patent/AU578813B2/en not_active Ceased
- 1986-02-24 KR KR1019860700771A patent/KR940002952B1/ko not_active IP Right Cessation
- 1986-02-24 WO PCT/US1986/000368 patent/WO1986005181A1/en active IP Right Grant
- 1986-02-24 EP EP86901675A patent/EP0215063B1/en not_active Expired - Lifetime
- 1986-02-24 HU HU862011A patent/HU196202B/hu not_active IP Right Cessation
- 1986-02-24 AT AT86901675T patent/ATE96790T1/de not_active IP Right Cessation
- 1986-03-03 GR GR860592A patent/GR860592B/el unknown
- 1986-03-03 IE IE56186A patent/IE63653B1/en not_active IP Right Cessation
- 1986-03-05 ES ES552684A patent/ES8704167A1/es not_active Expired
- 1986-03-06 EG EG107/86A patent/EG18371A/xx active
- 1986-03-06 PT PT82149A patent/PT82149B/pt not_active IP Right Cessation
- 1986-03-06 IL IL78059A patent/IL78059A/xx unknown
- 1986-03-07 NZ NZ215404A patent/NZ215404A/xx unknown
- 1986-03-07 PH PH33489A patent/PH23136A/en unknown
- 1986-03-07 CA CA000503509A patent/CA1276637C/en not_active Expired - Lifetime
- 1986-03-08 CN CN86101475A patent/CN1016174B/zh not_active Expired
- 1986-10-02 DK DK472186A patent/DK168666B1/da not_active IP Right Cessation
- 1986-10-31 ES ES557174A patent/ES8801268A1/es not_active Expired
- 1986-11-03 SU SU864028461A patent/SU1676449A3/ru active
-
1992
- 1992-06-25 MX MX9203357A patent/MX9203357A/es unknown
-
1995
- 1995-09-05 JP JP7228382A patent/JPH08193084A/ja active Pending
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed |