PT82149B - Processo para a preparacao de derivados de pirido{2,3-d}pirimidina - Google Patents

Processo para a preparacao de derivados de pirido{2,3-d}pirimidina

Info

Publication number
PT82149B
PT82149B PT82149A PT8214986A PT82149B PT 82149 B PT82149 B PT 82149B PT 82149 A PT82149 A PT 82149A PT 8214986 A PT8214986 A PT 8214986A PT 82149 B PT82149 B PT 82149B
Authority
PT
Portugal
Prior art keywords
pyridid
preparation
pyrimidine derivatives
pyrimidin
benzoyl
Prior art date
Application number
PT82149A
Other languages
English (en)
Other versions
PT82149A (en
Inventor
Edward C Taylor
George Peter Beardsley
Stephen R Fletcher
Peter J Harrington
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Publication of PT82149A publication Critical patent/PT82149A/pt
Publication of PT82149B publication Critical patent/PT82149B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
PT82149A 1985-03-08 1986-03-06 Processo para a preparacao de derivados de pirido{2,3-d}pirimidina PT82149B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70962285A 1985-03-08 1985-03-08

Publications (2)

Publication Number Publication Date
PT82149A PT82149A (en) 1986-04-01
PT82149B true PT82149B (pt) 1988-04-21

Family

ID=24850641

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82149A PT82149B (pt) 1985-03-08 1986-03-06 Processo para a preparacao de derivados de pirido{2,3-d}pirimidina

Country Status (22)

Country Link
EP (1) EP0215063B1 (pt)
JP (2) JPH0822860B2 (pt)
KR (1) KR940002952B1 (pt)
CN (1) CN1016174B (pt)
AT (1) ATE96790T1 (pt)
AU (1) AU578813B2 (pt)
CA (1) CA1276637C (pt)
DE (1) DE3689250T2 (pt)
DK (1) DK168666B1 (pt)
EG (1) EG18371A (pt)
ES (2) ES8704167A1 (pt)
GR (1) GR860592B (pt)
HU (1) HU196202B (pt)
IE (1) IE63653B1 (pt)
IL (1) IL78059A (pt)
MX (1) MX9203357A (pt)
NZ (1) NZ215404A (pt)
PH (1) PH23136A (pt)
PT (1) PT82149B (pt)
SU (1) SU1676449A3 (pt)
WO (1) WO1986005181A1 (pt)
ZA (1) ZA861235B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8702758D0 (en) * 1987-02-06 1987-03-11 Wellcome Found Treatment of disease
EP0278686A1 (en) * 1987-02-07 1988-08-17 The Wellcome Foundation Limited Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof
EP0305667A3 (en) * 1987-09-03 1989-10-25 American Cyanamid Company Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4889859A (en) * 1988-02-05 1989-12-26 The Trustees Of Princeton University Pyrido[2,3-d]pyrimidine derivatives
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2066898A1 (en) * 1991-04-29 1992-10-30 Chuan Shih Pharmaceutical compounds
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
WO1993020075A1 (en) * 1992-04-01 1993-10-14 The University Of Sydney 8-substituted-n5-deazapterins as antifolates
ZA932731B (en) * 1992-04-23 1994-10-19 Lilly Co Eli Method of treating gar-transformylase-dependent tumors
EP0638079B1 (en) * 1992-04-29 1999-12-15 Sri International Deazaaminopterins for treatment of inflammation
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
SG49234A1 (en) * 1993-01-29 1998-05-18 Agouron Pharma Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
CN1053448C (zh) * 1994-07-28 2000-06-14 阿格罗尼制药公司 用作抗增殖药物及garft抑制剂的化合物
RU2136686C1 (ru) * 1994-07-28 1999-09-10 Агурон Фармасьютикалз, Инк. Производные глутаминовой кислоты (варианты), фармацевтическая композиция, способ ингибирования роста и пролиферации клеток, производные тиофенкарбоновой кислоты (варианты)
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
EP1180369A4 (en) 1999-05-24 2002-07-24 Sankyo Co ANTI-FAS ANTIBODY MEDICAL COMPOSITIONS
ES3029483T3 (en) 2008-09-17 2025-06-24 Endocyte Inc Folate receptor binding conjugates of antifolates
CN116333411B (zh) * 2023-05-29 2023-08-11 石家庄启宏新材料制品有限公司 一种阻燃eva保温材料及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
EP0166726B1 (en) * 1983-12-27 1988-11-17 Sri International 10-ethyl-8,10-dideazaminopterins

Also Published As

Publication number Publication date
EP0215063A4 (en) 1987-11-23
EP0215063A1 (en) 1987-03-25
WO1986005181A1 (en) 1986-09-12
ES8801268A1 (es) 1987-12-16
PH23136A (en) 1989-05-11
IE63653B1 (en) 1995-05-31
ATE96790T1 (de) 1993-11-15
IL78059A (en) 1989-06-30
CN1016174B (zh) 1992-04-08
CA1276637C (en) 1990-11-20
DE3689250D1 (de) 1993-12-09
DE3689250T2 (de) 1994-03-03
KR940002952B1 (ko) 1994-04-09
JPH0822860B2 (ja) 1996-03-06
SU1676449A3 (ru) 1991-09-07
HUT41785A (en) 1987-05-28
DK472186A (da) 1986-12-19
JPS62502535A (ja) 1987-10-01
ES8704167A1 (es) 1987-03-16
ZA861235B (en) 1986-10-29
HU196202B (en) 1988-10-28
EG18371A (en) 1993-04-30
ES557174A0 (es) 1987-12-16
ES552684A0 (es) 1987-03-16
DK472186D0 (da) 1986-10-02
IE860561L (en) 1986-09-08
IL78059A0 (en) 1986-07-31
EP0215063B1 (en) 1993-11-03
JPH08193084A (ja) 1996-07-30
DK168666B1 (da) 1994-05-16
AU5510886A (en) 1986-09-24
GR860592B (en) 1986-06-26
MX9203357A (es) 1992-07-01
KR870700067A (ko) 1987-02-28
PT82149A (en) 1986-04-01
CN86101475A (zh) 1987-01-21
NZ215404A (en) 1990-03-27
AU578813B2 (en) 1988-11-03

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Effective date: 20050401