IL78059A - N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them - Google Patents

N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them

Info

Publication number
IL78059A
IL78059A IL78059A IL7805986A IL78059A IL 78059 A IL78059 A IL 78059A IL 78059 A IL78059 A IL 78059A IL 7805986 A IL7805986 A IL 7805986A IL 78059 A IL78059 A IL 78059A
Authority
IL
Israel
Prior art keywords
pyrimidin
amino
glutamic acid
alkyl
acid derivatives
Prior art date
Application number
IL78059A
Other languages
English (en)
Other versions
IL78059A0 (en
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Publication of IL78059A0 publication Critical patent/IL78059A0/xx
Priority to IL82249A priority Critical patent/IL82249A/xx
Publication of IL78059A publication Critical patent/IL78059A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
IL78059A 1985-03-08 1986-03-06 N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them IL78059A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL82249A IL82249A (en) 1986-03-06 1987-04-17 Diastereoisomers of n-(4-(2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido(2,3-d)-pyrimidin-6-yl)ethyl)-benzoyl-l-glutamic acid and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70962285A 1985-03-08 1985-03-08

Publications (2)

Publication Number Publication Date
IL78059A0 IL78059A0 (en) 1986-07-31
IL78059A true IL78059A (en) 1989-06-30

Family

ID=24850641

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78059A IL78059A (en) 1985-03-08 1986-03-06 N-(4-((2-amino-4-substituted-5,6,7,8-tetra-hydropyrido(2,3-d)-pyrimidin-6-yl)alkyl)-l-glutamic acid derivatives and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0215063B1 (xx)
JP (2) JPH0822860B2 (xx)
KR (1) KR940002952B1 (xx)
CN (1) CN1016174B (xx)
AT (1) ATE96790T1 (xx)
AU (1) AU578813B2 (xx)
CA (1) CA1276637C (xx)
DE (1) DE3689250T2 (xx)
DK (1) DK168666B1 (xx)
EG (1) EG18371A (xx)
ES (2) ES8704167A1 (xx)
GR (1) GR860592B (xx)
HU (1) HU196202B (xx)
IE (1) IE63653B1 (xx)
IL (1) IL78059A (xx)
MX (1) MX9203357A (xx)
NZ (1) NZ215404A (xx)
PH (1) PH23136A (xx)
PT (1) PT82149B (xx)
SU (1) SU1676449A3 (xx)
WO (1) WO1986005181A1 (xx)
ZA (1) ZA861235B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8702758D0 (en) * 1987-02-06 1987-03-11 Wellcome Found Treatment of disease
AU598093B2 (en) * 1987-02-07 1990-06-14 Wellcome Foundation Limited, The Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof
EP0305667A3 (en) * 1987-09-03 1989-10-25 American Cyanamid Company Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4889859A (en) * 1988-02-05 1989-12-26 The Trustees Of Princeton University Pyrido[2,3-d]pyrimidine derivatives
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2066898A1 (en) * 1991-04-29 1992-10-30 Chuan Shih Pharmaceutical compounds
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
WO1993020075A1 (en) * 1992-04-01 1993-10-14 The University Of Sydney 8-substituted-n5-deazapterins as antifolates
ZA932731B (en) * 1992-04-23 1994-10-19 Lilly Co Eli Method of treating gar-transformylase-dependent tumors
EP0638079B1 (en) * 1992-04-29 1999-12-15 Sri International Deazaaminopterins for treatment of inflammation
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
NZ261497A (en) * 1993-01-29 1997-06-24 Agouron Pharma 2-[4-[2-(2-amino-4-oxo-3h-pyrido[5,4-b]n-hetring)-ring containing hydrocarbyl chain]-amido]-pentanedioic acid
CN1053448C (zh) * 1994-07-28 2000-06-14 阿格罗尼制药公司 用作抗增殖药物及garft抑制剂的化合物
DE69432801T2 (de) * 1994-07-28 2003-12-04 Agouron Pharmaceuticals, Inc. Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sind
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
NZ515598A (en) * 1999-05-24 2004-05-28 Sankyo Co Synergistic medicinal compositions containing anti-Fas antibody and a compound having a folate antagonistic activity or a dihydrofolate reductase inhibiting activity
EP2349274A4 (en) 2008-09-17 2014-12-17 Endocyte Inc CONJUGATES OF ANTIFOLATES BINDING THE FOLATE RECEPTOR
CN116333411B (zh) * 2023-05-29 2023-08-11 石家庄启宏新材料制品有限公司 一种阻燃eva保温材料及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
JPS61500845A (ja) * 1983-12-27 1986-05-01 エス・ア−ル・アイ・インタ−ナシヨナル ８，１０―ジデアザミノプテリン及び抗白血病剤組成物

Also Published As

Publication number Publication date
JPH0822860B2 (ja) 1996-03-06
KR870700067A (ko) 1987-02-28
EP0215063A4 (en) 1987-11-23
JPH08193084A (ja) 1996-07-30
AU578813B2 (en) 1988-11-03
EG18371A (en) 1993-04-30
GR860592B (en) 1986-06-26
CA1276637C (en) 1990-11-20
DK168666B1 (da) 1994-05-16
ATE96790T1 (de) 1993-11-15
EP0215063A1 (en) 1987-03-25
PT82149B (pt) 1988-04-21
DK472186A (da) 1986-12-19
NZ215404A (en) 1990-03-27
HUT41785A (en) 1987-05-28
PT82149A (en) 1986-04-01
AU5510886A (en) 1986-09-24
MX9203357A (es) 1992-07-01
JPS62502535A (ja) 1987-10-01
IE63653B1 (en) 1995-05-31
IL78059A0 (en) 1986-07-31
ES557174A0 (es) 1987-12-16
CN1016174B (zh) 1992-04-08
ES552684A0 (es) 1987-03-16
DE3689250D1 (de) 1993-12-09
HU196202B (en) 1988-10-28
KR940002952B1 (ko) 1994-04-09
SU1676449A3 (ru) 1991-09-07
DK472186D0 (da) 1986-10-02
WO1986005181A1 (en) 1986-09-12
ZA861235B (en) 1986-10-29
EP0215063B1 (en) 1993-11-03
IE860561L (en) 1986-09-08
ES8704167A1 (es) 1987-03-16
ES8801268A1 (es) 1987-12-16
DE3689250T2 (de) 1994-03-03
PH23136A (en) 1989-05-11
CN86101475A (zh) 1987-01-21

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