IL77199A - Omega-(polysubstituted inden-2-yl)-3hydroxyaliphatic acid derivatives and delta-lactones thereof,their production and pharmaceutical compositions containing them - Google Patents

Omega-(polysubstituted inden-2-yl)-3hydroxyaliphatic acid derivatives and delta-lactones thereof,their production and pharmaceutical compositions containing them

Info

Publication number
IL77199A
IL77199A IL77199A IL7719985A IL77199A IL 77199 A IL77199 A IL 77199A IL 77199 A IL77199 A IL 77199A IL 7719985 A IL7719985 A IL 7719985A IL 77199 A IL77199 A IL 77199A
Authority
IL
Israel
Prior art keywords
6alkyl
hydrogen
inden
polysubstituted
lactones
Prior art date
Application number
IL77199A
Other languages
English (en)
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL77199A publication Critical patent/IL77199A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
IL77199A 1984-12-04 1985-12-02 Omega-(polysubstituted inden-2-yl)-3hydroxyaliphatic acid derivatives and delta-lactones thereof,their production and pharmaceutical compositions containing them IL77199A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67791784A 1984-12-04 1984-12-04

Publications (1)

Publication Number Publication Date
IL77199A true IL77199A (en) 1990-02-09

Family

ID=24720627

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77199A IL77199A (en) 1984-12-04 1985-12-02 Omega-(polysubstituted inden-2-yl)-3hydroxyaliphatic acid derivatives and delta-lactones thereof,their production and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP0216785B1 (fi)
JP (1) JPS62501009A (fi)
KR (1) KR910003427B1 (fi)
AT (1) ATE60571T1 (fi)
AU (1) AU599580B2 (fi)
DE (1) DE3581638D1 (fi)
DK (1) DK369086D0 (fi)
ES (1) ES8800888A1 (fi)
FI (1) FI863121A0 (fi)
GR (1) GR852895B (fi)
HU (1) HU198005B (fi)
IL (1) IL77199A (fi)
MY (1) MY100972A (fi)
NZ (1) NZ214402A (fi)
PH (1) PH24502A (fi)
PL (1) PL147645B1 (fi)
PT (1) PT81603B (fi)
WO (1) WO1986003488A1 (fi)
ZA (1) ZA859303B (fi)

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US4904691A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
US4876280A (en) * 1988-03-10 1989-10-24 Sandoz Pharm. Corp. Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use
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WO1990003962A1 (en) * 1988-10-13 1990-04-19 Sandoz Ag Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof
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US5025017A (en) * 1989-09-28 1991-06-18 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
US5189180A (en) * 1989-09-28 1993-02-23 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
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Also Published As

Publication number Publication date
WO1986003488A1 (en) 1986-06-19
JPS62501009A (ja) 1987-04-23
ZA859303B (en) 1987-07-29
PT81603B (pt) 1988-04-21
GR852895B (fi) 1986-04-01
PH24502A (en) 1990-07-18
HU198005B (en) 1989-07-28
HUT40398A (en) 1986-12-28
DE3581638D1 (de) 1991-03-07
EP0216785A1 (en) 1987-04-08
EP0216785B1 (en) 1991-01-30
PL147645B1 (en) 1989-07-31
PT81603A (en) 1986-01-01
AU599580B2 (en) 1990-07-26
KR910003427B1 (ko) 1991-05-31
AU5230686A (en) 1986-07-01
ES549546A0 (es) 1987-12-01
ES8800888A1 (es) 1987-12-01
FI863121A (fi) 1986-07-30
DK369086A (da) 1986-08-01
KR870700063A (ko) 1987-02-28
DK369086D0 (da) 1986-08-01
ATE60571T1 (de) 1991-02-15
NZ214402A (en) 1989-01-27
FI863121A0 (fi) 1986-07-30
PL256608A1 (en) 1988-01-07
MY100972A (en) 1991-06-15

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