IL73943A - 4h-3,1-benzoxazin-4-one derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

4h-3,1-benzoxazin-4-one derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL73943A
IL73943A IL73943A IL7394384A IL73943A IL 73943 A IL73943 A IL 73943A IL 73943 A IL73943 A IL 73943A IL 7394384 A IL7394384 A IL 7394384A IL 73943 A IL73943 A IL 73943A
Authority
IL
Israel
Prior art keywords
benzoxazin
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL73943A
Other languages
English (en)
Other versions
IL73943A0 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/673,996 external-priority patent/US4657893A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL73943A0 publication Critical patent/IL73943A0/xx
Publication of IL73943A publication Critical patent/IL73943A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/16—Derivatives of isocyanic acid having isocyanate groups acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL73943A 1983-12-27 1984-12-26 4h-3,1-benzoxazin-4-one derivatives,their preparation and pharmaceutical compositions containing them IL73943A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56612983A 1983-12-27 1983-12-27
US60860984A 1984-05-09 1984-05-09
US06/673,996 US4657893A (en) 1984-05-09 1984-11-26 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors

Publications (2)

Publication Number Publication Date
IL73943A0 IL73943A0 (en) 1985-03-31
IL73943A true IL73943A (en) 1989-01-31

Family

ID=27415984

Family Applications (1)

Application Number Title Priority Date Filing Date
IL73943A IL73943A (en) 1983-12-27 1984-12-26 4h-3,1-benzoxazin-4-one derivatives,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
EP (1) EP0147211B1 (hu)
KR (1) KR890000992B1 (hu)
CA (1) CA1269800A (hu)
DE (1) DE3483204D1 (hu)
DK (1) DK625184A (hu)
ES (2) ES8607260A1 (hu)
FI (1) FI79842C (hu)
HU (1) HU195648B (hu)
IL (1) IL73943A (hu)
NO (1) NO163184C (hu)
NZ (1) NZ210669A (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
ES2067140T3 (es) * 1990-09-10 1995-03-16 Asahi Chemical Ind Compuestos fenilester de acido benzoico y composiciones inhibidoras de la elastasa que contienen los mismos.
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
GB9700597D0 (en) * 1997-01-14 1997-03-05 Sandoz Pharma Uk Organic compounds
US6180625B1 (en) 1998-03-24 2001-01-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AU2826099A (en) * 1998-03-24 1999-10-18 Novo Nordisk A/S Heterocyclic compounds regulating clotting
WO2000030646A1 (en) * 1998-11-26 2000-06-02 Novo Nordisk A/S Heterocyclic compounds regulating clotting
GB9900416D0 (en) 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
WO2000043371A2 (en) 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4
EP1144388B1 (en) 1999-01-22 2010-01-13 Elan Pharmaceuticals, Inc. Acyl derivatives which treat vla-4 related disorders
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
JP5081828B2 (ja) 2005-09-29 2012-11-28 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物
NZ567270A (en) 2005-09-29 2011-06-30 Elan Pharm Inc Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
KR20080100271A (ko) 2006-02-27 2008-11-14 엘란 파마슈티칼스, 인크. Ｖｌａ-4에 의해 매개되는 백혈구 부착을 억제하는 피리미디닐 술폰아미드 화합물
JP2012525336A (ja) 2009-04-27 2012-10-22 エラン ファーマシューティカルズ，インコーポレイテッド α−４インテグリンのピリジノンアンタゴニスト
EP3565543A4 (en) * 2017-01-06 2020-10-14 The Regents of The University of California MU TYPE OPIOID RECEIVER MODULATORS
WO2019195634A1 (en) 2018-04-04 2019-10-10 Epiodyne, Inc. Opioid receptor modulators and products and methods related thereto
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450700A (en) * 1966-12-20 1969-06-17 Upjohn Co 2-tertiary amino-4h-3,1-benzoxazin-4-ones
DE2315303A1 (de) * 1973-03-27 1974-10-17 Bayer Ag Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen

Also Published As

Publication number Publication date
ES8607260A1 (es) 1986-06-01
FI845116L (fi) 1985-06-28
NO163184C (no) 1990-04-18
HUT36808A (en) 1985-10-28
IL73943A0 (en) 1985-03-31
FI845116A0 (fi) 1984-12-27
ES8703437A1 (es) 1987-03-01
FI79842B (fi) 1989-11-30
EP0147211B1 (en) 1990-09-12
NZ210669A (en) 1988-05-30
HU195648B (en) 1988-06-28
ES539038A0 (es) 1986-06-01
DK625184A (da) 1985-06-28
ES550879A0 (es) 1987-03-01
FI79842C (fi) 1990-03-12
DE3483204D1 (de) 1990-10-18
NO845176L (no) 1985-06-28
DK625184D0 (da) 1984-12-21
EP0147211A2 (en) 1985-07-03
EP0147211A3 (en) 1985-08-14
CA1269800A (en) 1990-05-29
KR850004472A (ko) 1985-07-15
KR890000992B1 (ko) 1989-04-15

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