IL73110A - Selective process of acylation of phenolic hydroxy groups of steroids of estrane series and a complex between n-disubstituted carbamoyl halogenides and 4-(tertiary amino)pyridines used in this process - Google Patents
Selective process of acylation of phenolic hydroxy groups of steroids of estrane series and a complex between n-disubstituted carbamoyl halogenides and 4-(tertiary amino)pyridines used in this processInfo
- Publication number
- IL73110A IL73110A IL73110A IL7311084A IL73110A IL 73110 A IL73110 A IL 73110A IL 73110 A IL73110 A IL 73110A IL 7311084 A IL7311084 A IL 7311084A IL 73110 A IL73110 A IL 73110A
- Authority
- IL
- Israel
- Prior art keywords
- steroids
- complex
- hydroxy groups
- tertiary amino
- acylation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 230000010933 acylation Effects 0.000 title abstract 2
- 238000005917 acylation reaction Methods 0.000 title abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002162 estranes Chemical class 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- -1 phenolic N-disubstituted carbamate esters Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
- Cephalosporin Compounds (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Press Drives And Press Lines (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8305596A SE8305596D0 (sv) | 1983-10-12 | 1983-10-12 | A selective acylation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL73110A true IL73110A (en) | 1988-02-29 |
Family
ID=20352856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL73110A IL73110A (en) | 1983-10-12 | 1984-09-26 | Selective process of acylation of phenolic hydroxy groups of steroids of estrane series and a complex between n-disubstituted carbamoyl halogenides and 4-(tertiary amino)pyridines used in this process |
Country Status (11)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2520074B2 (ja) * | 1992-06-11 | 1996-07-31 | 呉羽化学工業株式会社 | 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤 |
| JP2554005B2 (ja) * | 1993-02-18 | 1996-11-13 | 株式会社パーマケム・アジア | エストラムスチンフォスフェート又はその塩類の精製方法 |
| JP2554006B2 (ja) * | 1993-03-12 | 1996-11-13 | 株式会社パーマケム・アジア | エストラジオールの選択的アシル化方法 |
| DE19906159A1 (de) * | 1999-02-09 | 2000-08-10 | Schering Ag | 16-Hydroxyestratriene als selektiv wirksame Estrogene |
| US9440899B2 (en) | 2014-12-15 | 2016-09-13 | Rohm And Haas Electronic Materials Llc | Purification method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1016959A (en) * | 1963-04-09 | 1966-01-12 | Leo Ab | Substituted steroid hormones |
| DE1958954C3 (de) * | 1969-11-24 | 1978-11-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Veresterung von Alkoholen |
| GB1528321A (en) * | 1975-07-07 | 1978-10-11 | Leo Ab | Acylation process for the preparation of phenolic n,n-di-substituted carbamate esters |
| GB1565680A (en) * | 1976-12-31 | 1980-04-23 | Leo Ab | Method for the preparation of carboxylic acid esters |
-
1983
- 1983-10-12 SE SE8305596A patent/SE8305596D0/xx unknown
-
1984
- 1984-09-24 IE IE243284A patent/IE58786B1/en not_active IP Right Cessation
- 1984-09-26 IL IL73110A patent/IL73110A/xx not_active IP Right Cessation
- 1984-09-28 US US06/655,950 patent/US4592869A/en not_active Expired - Lifetime
- 1984-10-03 EP EP84111804A patent/EP0138153B1/en not_active Expired
- 1984-10-03 AT AT84111804T patent/ATE38840T1/de not_active IP Right Cessation
- 1984-10-03 DE DE8484111804T patent/DE3475308D1/de not_active Expired
- 1984-10-09 FI FI843964A patent/FI81105C/fi not_active IP Right Cessation
- 1984-10-09 CA CA000464993A patent/CA1244822A/en not_active Expired
- 1984-10-11 HU HU843817A patent/HU195231B/hu unknown
- 1984-10-12 JP JP59214025A patent/JPS6097996A/ja active Granted
-
1993
- 1993-03-22 JP JP5062067A patent/JPH0720938B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI81105C (fi) | 1990-09-10 |
| FI843964A0 (fi) | 1984-10-09 |
| US4592869A (en) | 1986-06-03 |
| IE58786B1 (en) | 1993-11-17 |
| HUT37157A (en) | 1985-11-28 |
| EP0138153A2 (en) | 1985-04-24 |
| HU195231B (en) | 1988-04-28 |
| CA1244822A (en) | 1988-11-15 |
| SE8305596D0 (sv) | 1983-10-12 |
| JPH0720938B2 (ja) | 1995-03-08 |
| EP0138153B1 (en) | 1988-11-23 |
| JPH0680690A (ja) | 1994-03-22 |
| DE3475308D1 (en) | 1988-12-29 |
| JPS6097996A (ja) | 1985-05-31 |
| FI843964L (fi) | 1985-04-13 |
| EP0138153A3 (en) | 1986-04-09 |
| IE842432L (en) | 1985-04-12 |
| JPH0559920B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-09-01 |
| ATE38840T1 (de) | 1988-12-15 |
| FI81105B (fi) | 1990-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH | Patent void | ||
| KB | Patent renewed | ||
| EXP | Patent expired |