IL71435A - Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids - Google Patents
Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluidsInfo
- Publication number
- IL71435A IL71435A IL71435A IL7143584A IL71435A IL 71435 A IL71435 A IL 71435A IL 71435 A IL71435 A IL 71435A IL 7143584 A IL7143584 A IL 7143584A IL 71435 A IL71435 A IL 71435A
- Authority
- IL
- Israel
- Prior art keywords
- iodothyronines
- determining
- enzyme
- immunoassay method
- reagents
- Prior art date
Links
- VSWSDTLXDWESGZ-AWEZNQCLSA-N (2s)-3-[4-(4-hydroxyphenoxy)phenyl]-2-(iodoamino)propanoic acid Chemical class C1=CC(C[C@@H](C(=O)O)NI)=CC=C1OC1=CC=C(O)C=C1 VSWSDTLXDWESGZ-AWEZNQCLSA-N 0.000 title abstract 4
- 238000003018 immunoassay Methods 0.000 title abstract 3
- 239000013060 biological fluid Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000009488 Thyroxine-Binding Proteins Human genes 0.000 abstract 2
- 108010048889 Thyroxine-Binding Proteins Proteins 0.000 abstract 2
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 abstract 2
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 239000002981 blocking agent Substances 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 239000005515 coenzyme Substances 0.000 abstract 1
- 230000009137 competitive binding Effects 0.000 abstract 1
- -1 e.g. Chemical compound 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229940034208 thyroxine Drugs 0.000 abstract 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/510,814 US4622293A (en) | 1983-07-05 | 1983-07-05 | Iodothyronine immunoassays employing HMS as TBP blocking agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL71435A0 IL71435A0 (en) | 1984-07-31 |
| IL71435A true IL71435A (en) | 1987-10-20 |
Family
ID=24032316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL71435A IL71435A (en) | 1983-07-05 | 1984-04-03 | Immunoassay method,reagents,test kit and test device for determining iodothyronines in biological fluids |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4622293A (xx) |
| EP (1) | EP0133464B1 (xx) |
| JP (1) | JPS6038654A (xx) |
| AT (1) | ATE24971T1 (xx) |
| AU (1) | AU545412B2 (xx) |
| CA (1) | CA1225024A (xx) |
| DE (1) | DE3462072D1 (xx) |
| DK (1) | DK160335C (xx) |
| ES (1) | ES8604694A1 (xx) |
| IE (1) | IE55677B1 (xx) |
| IL (1) | IL71435A (xx) |
| NO (1) | NO163586C (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0165669A1 (en) * | 1984-05-04 | 1985-12-27 | Corning Glass Works | Improved method of measuring free ligand |
| DE3650437T2 (de) * | 1985-10-04 | 1996-04-18 | Diagnostic Products Corp | Verfahren zum Messen von Freiliganden in biologischen Flüssigkeiten. |
| US5102786A (en) * | 1987-05-21 | 1992-04-07 | Pb Diagnostic Systems, Inc. | Biological diagnostic assay system |
| EP0312897A1 (en) * | 1987-10-21 | 1989-04-26 | Abbott Laboratories | Thyroid hormone assay and reagent system employing furosemide |
| US5063165A (en) * | 1988-12-22 | 1991-11-05 | Syntex (U.S.A.) Inc. | Geminal diphenyl derivatives and their use in immunoassays |
| US5256575A (en) * | 1988-12-22 | 1993-10-26 | Syntex (U.S.A.) Inc. | Geminal diphenyl derivatives and their use in immunoassays |
| US5593844A (en) * | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
| US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
| US6326154B1 (en) | 1990-11-19 | 2001-12-04 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
| DE4103167A1 (de) * | 1991-02-02 | 1992-08-06 | Boehringer Mannheim Gmbh | Diphenylmethanderivate, verfahren zu deren herstellung und ihre verwendung zur verdraengung von jodthyroninen von diesen bindenden proteinen |
| US7141436B2 (en) * | 1999-11-03 | 2006-11-28 | Science And Technology Corp. | Immunoassay and reagents and kits for performing the same |
| EP1641492B1 (en) | 2003-07-08 | 2011-12-14 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of adp antagonists |
| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| EP1836495A2 (en) * | 2004-11-17 | 2007-09-26 | BioVeris Corporation | Electrochemiluminescent assay |
| US20060275841A1 (en) * | 2004-12-20 | 2006-12-07 | Martin Blankfard | Assay method and apparatus with reduced sample matrix effects |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928553A (en) * | 1972-03-23 | 1975-12-23 | Univ New York | Radioimmunoassay method for triiodothyronine and thyroxine |
| US3911096A (en) * | 1972-06-23 | 1975-10-07 | Professional Staff Ass Of The | Radioimmunoassay for measurement of thyroxine (T{HD 4{B ) and triiodothyonine (T{HD 3{B ) in blood serum |
| CA1050425A (en) * | 1975-06-26 | 1979-03-13 | Mallinckrodt | Radioimmunoassay methods for the determination of l-triiodothyronine and thyroxine |
| CA1183450A (en) * | 1980-10-30 | 1985-03-05 | Alfred C. Greenquist | Homogeneous specific binding assay device and method |
| US4468469A (en) * | 1981-11-04 | 1984-08-28 | Miles Laboratories, Inc. | Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays |
-
1983
- 1983-07-05 US US06/510,814 patent/US4622293A/en not_active Expired - Fee Related
-
1984
- 1984-04-03 IL IL71435A patent/IL71435A/xx not_active IP Right Cessation
- 1984-04-04 CA CA000451292A patent/CA1225024A/en not_active Expired
- 1984-04-12 AU AU26776/84A patent/AU545412B2/en not_active Ceased
- 1984-06-21 NO NO842519A patent/NO163586C/no unknown
- 1984-06-25 AT AT84107264T patent/ATE24971T1/de not_active IP Right Cessation
- 1984-06-25 EP EP84107264A patent/EP0133464B1/en not_active Expired
- 1984-06-25 DE DE8484107264T patent/DE3462072D1/de not_active Expired
- 1984-07-04 ES ES534023A patent/ES8604694A1/es not_active Expired
- 1984-07-04 JP JP59137416A patent/JPS6038654A/ja active Pending
- 1984-07-04 DK DK328584A patent/DK160335C/da not_active IP Right Cessation
- 1984-07-04 IE IE1702/84A patent/IE55677B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8604694A1 (es) | 1986-02-01 |
| DK160335C (da) | 1991-07-29 |
| DK328584A (da) | 1985-01-06 |
| CA1225024A (en) | 1987-08-04 |
| US4622293A (en) | 1986-11-11 |
| EP0133464B1 (en) | 1987-01-14 |
| NO163586C (no) | 1990-06-20 |
| AU2677684A (en) | 1985-01-10 |
| ES534023A0 (es) | 1986-02-01 |
| NO842519L (no) | 1985-01-07 |
| DK328584D0 (da) | 1984-07-04 |
| IL71435A0 (en) | 1984-07-31 |
| DE3462072D1 (en) | 1987-02-19 |
| ATE24971T1 (de) | 1987-01-15 |
| IE841702L (en) | 1985-01-05 |
| NO163586B (no) | 1990-03-12 |
| DK160335B (da) | 1991-02-25 |
| JPS6038654A (ja) | 1985-02-28 |
| EP0133464A1 (en) | 1985-02-27 |
| IE55677B1 (en) | 1990-12-19 |
| AU545412B2 (en) | 1985-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |