ES8604694A1 - Mejoras introducidas en un metodo de inmunoensayo para determinar una yodotironina en un fluido biologico - Google Patents

Mejoras introducidas en un metodo de inmunoensayo para determinar una yodotironina en un fluido biologico

Info

Publication number
ES8604694A1
ES8604694A1 ES534023A ES534023A ES8604694A1 ES 8604694 A1 ES8604694 A1 ES 8604694A1 ES 534023 A ES534023 A ES 534023A ES 534023 A ES534023 A ES 534023A ES 8604694 A1 ES8604694 A1 ES 8604694A1
Authority
ES
Spain
Prior art keywords
blocking agent
hms
immunoassays employing
tbp
iodothyronine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534023A
Other languages
English (en)
Other versions
ES534023A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of ES534023A0 publication Critical patent/ES534023A0/es
Publication of ES8604694A1 publication Critical patent/ES8604694A1/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Steroid Compounds (AREA)

Abstract

METODO DE INMUNOENSAYO DE UNION COMPETITIVA PARA DETERMINAR UNA YODOTIRONINA EN UN FLUIDO BIOLOGICO. CONSISTE EN COMBINAR UNA MUESTRA DE SUERO O PLASMA CON UN ANTICUERPO FRENTE A YODOTIRONINA, CON UNA FORMA MARCADA DE DICHA YODOTIRONINA Y UN AGENTE BLOQUEANTE DE LA UNION DE DICHA YODOTIRONINA A LA PROTEINA LIGANTE DE TIROXINA EN LA CIRTADA MUESTRA, DONDE EL AGENTE BLOQUEANTE ES ACIDO 2-HIDROXI-4-METOXIBENZOFENON-5-SULFONICO O UNA SAL DEL MISMO, Y DONDE LA PROPORCION DE YODOTIRONINA MARCADA QUE SE UNE AL CITADO ANTICUERPO EN COMPARACION CON LA QUE QUEDA SIN UNIR DEPENDE DE LA CONCENTRACION DE DICHA YODOTIRONINA EN LA CITADA MUESTRA (0,25 A 5 MM). SIENDO EL MARCADOR, UN SUSTRATO DE ENZIMA, UN COENZIMA, UN INHIBIDOR DE ENZIMA, UN GRUPO PROTESICO DE ENZIMA; LA YODOTIRONINA, TRIYODOTIRONINA. SE UTILIZA EN EL DIAGNOSTICO DE LOS TRASTORNOS TIROIDEOS.
ES534023A 1983-07-05 1984-07-04 Mejoras introducidas en un metodo de inmunoensayo para determinar una yodotironina en un fluido biologico Expired ES8604694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/510,814 US4622293A (en) 1983-07-05 1983-07-05 Iodothyronine immunoassays employing HMS as TBP blocking agent

Publications (2)

Publication Number Publication Date
ES534023A0 ES534023A0 (es) 1986-02-01
ES8604694A1 true ES8604694A1 (es) 1986-02-01

Family

ID=24032316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534023A Expired ES8604694A1 (es) 1983-07-05 1984-07-04 Mejoras introducidas en un metodo de inmunoensayo para determinar una yodotironina en un fluido biologico

Country Status (12)

Country Link
US (1) US4622293A (es)
EP (1) EP0133464B1 (es)
JP (1) JPS6038654A (es)
AT (1) ATE24971T1 (es)
AU (1) AU545412B2 (es)
CA (1) CA1225024A (es)
DE (1) DE3462072D1 (es)
DK (1) DK160335C (es)
ES (1) ES8604694A1 (es)
IE (1) IE55677B1 (es)
IL (1) IL71435A (es)
NO (1) NO163586C (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165669A1 (en) * 1984-05-04 1985-12-27 Corning Glass Works Improved method of measuring free ligand
EP0218309B1 (en) * 1985-10-04 1995-11-15 Diagnostic Products Corporation Method for measuring free ligands in biological fluids
US5102786A (en) * 1987-05-21 1992-04-07 Pb Diagnostic Systems, Inc. Biological diagnostic assay system
EP0312897A1 (en) * 1987-10-21 1989-04-26 Abbott Laboratories Thyroid hormone assay and reagent system employing furosemide
US5256575A (en) * 1988-12-22 1993-10-26 Syntex (U.S.A.) Inc. Geminal diphenyl derivatives and their use in immunoassays
US5063165A (en) * 1988-12-22 1991-11-05 Syntex (U.S.A.) Inc. Geminal diphenyl derivatives and their use in immunoassays
US5593844A (en) * 1990-11-19 1997-01-14 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
US5210017A (en) * 1990-11-19 1993-05-11 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
US6326154B1 (en) 1990-11-19 2001-12-04 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
DE4103167A1 (de) * 1991-02-02 1992-08-06 Boehringer Mannheim Gmbh Diphenylmethanderivate, verfahren zu deren herstellung und ihre verwendung zur verdraengung von jodthyroninen von diesen bindenden proteinen
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
WO2005007868A2 (en) 2003-07-08 2005-01-27 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
US20070243632A1 (en) 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
JP2008521007A (ja) * 2004-11-17 2008-06-19 バイオヴェリス コーポレイション 電気化学発光測定法
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928553A (en) * 1972-03-23 1975-12-23 Univ New York Radioimmunoassay method for triiodothyronine and thyroxine
US3911096A (en) * 1972-06-23 1975-10-07 Professional Staff Ass Of The Radioimmunoassay for measurement of thyroxine (T{HD 4{B ) and triiodothyonine (T{HD 3{B ) in blood serum
NL7605447A (nl) * 1975-06-26 1976-12-28 Byk Mallinckrodt Chem Prod Radioimmunoproefmethode voor de bepaling van thyroxine.
CA1183450A (en) * 1980-10-30 1985-03-05 Alfred C. Greenquist Homogeneous specific binding assay device and method
US4468469A (en) * 1981-11-04 1984-08-28 Miles Laboratories, Inc. Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays

Also Published As

Publication number Publication date
NO163586C (no) 1990-06-20
IL71435A0 (en) 1984-07-31
NO842519L (no) 1985-01-07
ATE24971T1 (de) 1987-01-15
AU2677684A (en) 1985-01-10
ES534023A0 (es) 1986-02-01
AU545412B2 (en) 1985-07-11
EP0133464B1 (en) 1987-01-14
JPS6038654A (ja) 1985-02-28
DE3462072D1 (en) 1987-02-19
DK328584A (da) 1985-01-06
IE841702L (en) 1985-01-05
DK328584D0 (da) 1984-07-04
DK160335B (da) 1991-02-25
EP0133464A1 (en) 1985-02-27
IL71435A (en) 1987-10-20
IE55677B1 (en) 1990-12-19
CA1225024A (en) 1987-08-04
DK160335C (da) 1991-07-29
NO163586B (no) 1990-03-12
US4622293A (en) 1986-11-11

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