IL70733A - Antihypertensive n-piperazinylalkanoylanilides,their preparation and pharmaceutical compositions comprising them - Google Patents
Antihypertensive n-piperazinylalkanoylanilides,their preparation and pharmaceutical compositions comprising themInfo
- Publication number
- IL70733A IL70733A IL70733A IL7073384A IL70733A IL 70733 A IL70733 A IL 70733A IL 70733 A IL70733 A IL 70733A IL 7073384 A IL7073384 A IL 7073384A IL 70733 A IL70733 A IL 70733A
- Authority
- IL
- Israel
- Prior art keywords
- piperazinylalkanoylanilides
- antihypertensive
- preparation
- pharmaceutical compositions
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838303946A GB8303946D0 (en) | 1983-02-12 | 1983-02-12 | Antihypertensive n-piperazinylalkanoylanilides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL70733A0 IL70733A0 (en) | 1984-04-30 |
| IL70733A true IL70733A (en) | 1987-10-30 |
Family
ID=10537908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL70733A IL70733A (en) | 1983-02-12 | 1984-01-20 | Antihypertensive n-piperazinylalkanoylanilides,their preparation and pharmaceutical compositions comprising them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4940711A (fr) |
| EP (1) | EP0120558B1 (fr) |
| JP (1) | JPS59152379A (fr) |
| KR (1) | KR910000451B1 (fr) |
| AR (1) | AR241182A1 (fr) |
| AT (1) | ATE41150T1 (fr) |
| AU (1) | AU565208B2 (fr) |
| CA (1) | CA1254894A (fr) |
| DE (1) | DE3476998D1 (fr) |
| DK (1) | DK162640C (fr) |
| ES (1) | ES8507529A1 (fr) |
| FI (1) | FI80025C (fr) |
| GB (1) | GB8303946D0 (fr) |
| GR (1) | GR81460B (fr) |
| HU (1) | HU191270B (fr) |
| IE (1) | IE56652B1 (fr) |
| IL (1) | IL70733A (fr) |
| MX (1) | MX156049A (fr) |
| NZ (1) | NZ206823A (fr) |
| PH (1) | PH20244A (fr) |
| PT (1) | PT78081B (fr) |
| SG (1) | SG34889G (fr) |
| ZA (1) | ZA84316B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8303946D0 (en) * | 1983-02-12 | 1983-03-16 | Recordati Chem Pharm | Antihypertensive n-piperazinylalkanoylanilides |
| JPS61134382A (ja) * | 1984-12-04 | 1986-06-21 | Kyorin Pharmaceut Co Ltd | 新規なスルファモイル安息香酸誘導体およびその製造法 |
| IT1190375B (it) * | 1985-06-20 | 1988-02-16 | Recordati Chem Pharm | N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica |
| DE3642497A1 (de) * | 1986-12-12 | 1988-06-23 | Hoechst Ag | Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte |
| JP2712222B2 (ja) * | 1988-01-29 | 1998-02-10 | 三菱化学株式会社 | 抗不安薬 |
| DK203990D0 (da) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
| US20160214967A1 (en) * | 2013-09-30 | 2016-07-28 | The University Of Tokyo | Activator of adiponectin receptor |
| EP3193941B1 (fr) * | 2014-08-06 | 2024-05-22 | Ascendis Pharma A/S | Promédicaments comprenant un liant de type aminoalkylglycine |
| US20180305334A1 (en) * | 2015-10-14 | 2018-10-25 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB912788A (en) * | 1959-11-16 | 1962-12-12 | Miles Lab | Phenylpiperazinylacyl anilines |
| DE1670200A1 (de) * | 1967-03-22 | 1972-03-02 | Byk Gulden Lomberg Chem Fab | Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung |
| JPS5064282A (fr) * | 1973-10-17 | 1975-05-31 | ||
| JPS5849550B2 (ja) * | 1974-02-07 | 1983-11-05 | 住友化学工業株式会社 | シンキナアニリンユウドウタイ ノ セイホウ |
| GB1574019A (en) * | 1977-01-14 | 1980-09-03 | Joullie International Sa | Therapeutically useful 3,4,5-trimethoxybenzene derivatives |
| US4202978A (en) * | 1978-02-08 | 1980-05-13 | Hoffmann-La Roche Inc. | (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines |
| JPS58154573A (ja) * | 1982-03-09 | 1983-09-14 | Mitsubishi Chem Ind Ltd | アルキレンジオキシベンゼン誘導体及びその酸付加塩 |
| GB8303946D0 (en) * | 1983-02-12 | 1983-03-16 | Recordati Chem Pharm | Antihypertensive n-piperazinylalkanoylanilides |
-
1983
- 1983-02-12 GB GB838303946A patent/GB8303946D0/en active Pending
-
1984
- 1984-01-12 NZ NZ206823A patent/NZ206823A/en unknown
- 1984-01-16 ZA ZA84316A patent/ZA84316B/xx unknown
- 1984-01-20 IL IL70733A patent/IL70733A/xx not_active IP Right Cessation
- 1984-01-23 AT AT84300375T patent/ATE41150T1/de not_active IP Right Cessation
- 1984-01-23 DE DE8484300375T patent/DE3476998D1/de not_active Expired
- 1984-01-23 EP EP84300375A patent/EP0120558B1/fr not_active Expired
- 1984-01-30 IE IE207/84A patent/IE56652B1/en not_active IP Right Cessation
- 1984-02-03 DK DK048584A patent/DK162640C/da not_active IP Right Cessation
- 1984-02-06 FI FI840478A patent/FI80025C/fi not_active IP Right Cessation
- 1984-02-06 JP JP59020672A patent/JPS59152379A/ja active Granted
- 1984-02-08 GR GR73748A patent/GR81460B/el unknown
- 1984-02-09 AR AR84295676A patent/AR241182A1/es active
- 1984-02-09 PT PT78081A patent/PT78081B/pt not_active IP Right Cessation
- 1984-02-09 MX MX200274A patent/MX156049A/es unknown
- 1984-02-10 KR KR8400641A patent/KR910000451B1/ko not_active IP Right Cessation
- 1984-02-10 CA CA000447172A patent/CA1254894A/fr not_active Expired
- 1984-02-10 ES ES529642A patent/ES8507529A1/es not_active Expired
- 1984-02-10 PH PH30227A patent/PH20244A/en unknown
- 1984-02-10 AU AU24494/84A patent/AU565208B2/en not_active Ceased
- 1984-02-10 HU HU84542A patent/HU191270B/hu not_active IP Right Cessation
-
1989
- 1989-05-25 SG SG348/89A patent/SG34889G/en unknown
- 1989-06-30 US US07/373,451 patent/US4940711A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR910000451B1 (en) | 1991-01-25 |
| GR81460B (fr) | 1984-12-11 |
| FI840478A (fi) | 1984-08-13 |
| DK48584A (da) | 1984-08-13 |
| DK48584D0 (da) | 1984-02-03 |
| HU191270B (en) | 1987-01-28 |
| EP0120558B1 (fr) | 1989-03-08 |
| ES529642A0 (es) | 1985-09-01 |
| FI80025C (fi) | 1990-04-10 |
| JPS59152379A (ja) | 1984-08-31 |
| MX156049A (es) | 1988-06-21 |
| DK162640B (da) | 1991-11-25 |
| GB8303946D0 (en) | 1983-03-16 |
| AU2449484A (en) | 1984-08-16 |
| EP0120558A1 (fr) | 1984-10-03 |
| PT78081B (en) | 1986-04-17 |
| CA1254894A (fr) | 1989-05-30 |
| AR241182A1 (es) | 1992-01-31 |
| ZA84316B (en) | 1985-02-27 |
| NZ206823A (en) | 1987-07-31 |
| IE840207L (en) | 1984-08-14 |
| PT78081A (en) | 1984-03-01 |
| ATE41150T1 (de) | 1989-03-15 |
| SG34889G (en) | 1989-10-13 |
| US4940711A (en) | 1990-07-10 |
| ES8507529A1 (es) | 1985-09-01 |
| IL70733A0 (en) | 1984-04-30 |
| KR840007593A (ko) | 1984-12-08 |
| PH20244A (en) | 1986-11-10 |
| AU565208B2 (en) | 1987-09-10 |
| DE3476998D1 (de) | 1989-04-13 |
| IE56652B1 (en) | 1991-10-23 |
| DK162640C (da) | 1992-04-13 |
| JPH0434549B2 (fr) | 1992-06-08 |
| FI80025B (fi) | 1989-12-29 |
| FI840478A0 (fi) | 1984-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |