IL68964A - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Info

Publication number
IL68964A
IL68964A IL68964A IL6896483A IL68964A IL 68964 A IL68964 A IL 68964A IL 68964 A IL68964 A IL 68964A IL 6896483 A IL6896483 A IL 6896483A IL 68964 A IL68964 A IL 68964A
Authority
IL
Israel
Prior art keywords
sub
hydrogen
lower alkyl
same
benzazepines
Prior art date
Application number
IL68964A
Other languages
English (en)
Other versions
IL68964A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL68964A0 publication Critical patent/IL68964A0/xx
Publication of IL68964A publication Critical patent/IL68964A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL68964A 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments IL68964A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof

Publications (2)

Publication Number Publication Date
IL68964A0 IL68964A0 (en) 1983-10-31
IL68964A true IL68964A (en) 1988-03-31

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68964A IL68964A (en) 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Country Status (17)

Country Link
US (1) US4988690A (cg-RX-API-DMAC7.html)
EP (1) EP0096838B1 (cg-RX-API-DMAC7.html)
JP (1) JPS595165A (cg-RX-API-DMAC7.html)
KR (1) KR900001214B1 (cg-RX-API-DMAC7.html)
AT (1) ATE26263T1 (cg-RX-API-DMAC7.html)
AU (1) AU570920B2 (cg-RX-API-DMAC7.html)
CA (1) CA1214460A (cg-RX-API-DMAC7.html)
DE (1) DE3370621D1 (cg-RX-API-DMAC7.html)
DK (1) DK270983A (cg-RX-API-DMAC7.html)
ES (1) ES8503666A1 (cg-RX-API-DMAC7.html)
FI (1) FI78473C (cg-RX-API-DMAC7.html)
GR (1) GR78291B (cg-RX-API-DMAC7.html)
HU (1) HU190902B (cg-RX-API-DMAC7.html)
IE (1) IE55404B1 (cg-RX-API-DMAC7.html)
IL (1) IL68964A (cg-RX-API-DMAC7.html)
PT (1) PT76864B (cg-RX-API-DMAC7.html)
ZA (1) ZA834309B (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
ZA885824B (en) * 1987-08-14 1989-04-26 Merrell Dow Pharma Novel antidepressants
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
WO2002044144A2 (en) * 2000-11-30 2002-06-06 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US8168624B2 (en) 2004-12-21 2012-05-01 Arena Pharmaceuticals, Inc. Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP2111859A1 (en) * 2004-12-23 2009-10-28 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (ja) * 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8987252B2 (en) 2007-05-10 2015-03-24 Albany Molecular Research, Inc. Aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
KR20180094131A (ko) 2010-09-01 2018-08-22 에자이 알앤드디 매니지먼트 가부시키가이샤 신장 손상을 갖는 개체에 대한 로카세린의 투여
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
KR900001214B1 (ko) 1990-02-28
EP0096838B1 (en) 1987-04-01
ES523191A0 (es) 1985-03-01
DE3370621D1 (en) 1987-05-07
ZA834309B (en) 1984-03-28
FI832092A0 (fi) 1983-06-10
JPH0365342B2 (cg-RX-API-DMAC7.html) 1991-10-11
AU1576483A (en) 1983-12-22
HU190902B (en) 1986-12-28
EP0096838A1 (en) 1983-12-28
IE831384L (en) 1983-12-14
AU570920B2 (en) 1988-03-31
FI78473B (fi) 1989-04-28
CA1214460A (en) 1986-11-25
DK270983A (da) 1983-12-15
JPS595165A (ja) 1984-01-12
ES8503666A1 (es) 1985-03-01
KR840005103A (ko) 1984-11-03
IL68964A0 (en) 1983-10-31
PT76864B (en) 1986-02-27
FI832092L (fi) 1983-12-15
US4988690A (en) 1991-01-29
PT76864A (en) 1983-07-01
DK270983D0 (da) 1983-06-13
ATE26263T1 (de) 1987-04-15
FI78473C (fi) 1989-08-10
GR78291B (cg-RX-API-DMAC7.html) 1984-09-26
IE55404B1 (en) 1990-09-12

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