IL68075A0 - Pyridine and pyrane derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Pyridine and pyrane derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL68075A0 IL68075A0 IL68075A IL6807583A IL68075A0 IL 68075 A0 IL68075 A0 IL 68075A0 IL 68075 A IL68075 A IL 68075A IL 6807583 A IL6807583 A IL 6807583A IL 68075 A0 IL68075 A0 IL 68075A0
- Authority
- IL
- Israel
- Prior art keywords
- radical
- oxygen atom
- optionally substituted
- aryl
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823208628 DE3208628A1 (de) | 1982-03-10 | 1982-03-10 | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
IL68075A0 true IL68075A0 (en) | 1983-06-15 |
Family
ID=6157837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL68075A IL68075A0 (en) | 1982-03-10 | 1983-03-07 | Pyridine and pyrane derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
US (1) | US4622332A (el) |
EP (1) | EP0088276B1 (el) |
JP (1) | JPS58164575A (el) |
KR (1) | KR840004074A (el) |
AT (1) | ATE19513T1 (el) |
AU (1) | AU1214383A (el) |
CA (1) | CA1239401A (el) |
DE (2) | DE3208628A1 (el) |
DK (1) | DK114783A (el) |
ES (1) | ES520441A0 (el) |
FI (1) | FI830776L (el) |
GR (1) | GR78508B (el) |
IL (1) | IL68075A0 (el) |
NO (1) | NO830612L (el) |
PH (1) | PH20468A (el) |
PT (1) | PT76316B (el) |
ZA (1) | ZA831633B (el) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
CH663616A5 (de) * | 1983-06-21 | 1987-12-31 | Sandoz Ag | 1,4-dihydropyridin-derivate und sie enthaltende pharmazeutische zubereitungen. |
JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
US4672068A (en) * | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
FR2568773B1 (fr) * | 1984-08-10 | 1989-03-03 | Sandoz Lab | Nouvelles compositions pharmaceutiques administrables par voie nasale |
AT381306B (de) * | 1984-08-28 | 1986-09-25 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridindicarbonsaeureestern |
NO854021L (no) * | 1984-10-26 | 1986-04-28 | Bayer Ag | 1,4-dihydropyridin-hydroksyaminer og fremgangsmaate til fremstilling derav. |
HUT39179A (en) * | 1984-12-10 | 1986-08-28 | Sandoz Ag | Process for production of derivatives of 1,4-dihydro-piridin |
US4833150A (en) * | 1985-03-14 | 1989-05-23 | Nelson Research & Development Co. | 1,4-dihydropyridines |
US4659717A (en) * | 1985-08-21 | 1987-04-21 | Eli Lilly And Company | Dihydropyridines useful in the treatment of angina and stroke |
US4735956A (en) * | 1985-09-13 | 1988-04-05 | Merck & Co., Inc. | Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers |
JPS62174050A (ja) * | 1985-10-21 | 1987-07-30 | Nippon Shoji Kk | 3−アミノカルボニル−1,4−ジヒドロピリジン−5−カルボン酸誘導体、その製法および医薬組成物 |
DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
US4849436A (en) * | 1986-03-11 | 1989-07-18 | Nelson Research & Development Co. | 1,4-dihydropyridines |
FR2596760B1 (fr) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
US4814455A (en) * | 1986-04-16 | 1989-03-21 | Bristol-Myers Company | Dihydro-3,5-dicarboxylates |
US4769382A (en) * | 1986-09-30 | 1988-09-06 | Institut Organischeskogo Sinteza Leningradsky Nauchno-Issledovatelsky Institut | Preparation for preventing and treatment of skin radiation burn lesions |
DE3724909A1 (de) * | 1987-07-28 | 1989-02-09 | Bayer Ag | Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung |
US5470982A (en) * | 1988-01-20 | 1995-11-28 | Bayer Aktiengesellschaft | Disubstituted pyridines |
JPH01151557A (ja) * | 1988-11-15 | 1989-06-14 | Otsuka Pharmaceut Co Ltd | 降圧剤 |
JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | 2−ハロエトキシカルボニル基を含有する1,4−ジヒドロピリジン誘導体の製造法 |
DK0595164T3 (da) * | 1992-10-30 | 1997-05-26 | Bayer Ag | 4-Heterocyclophenyl-substituerede dihydropyridiner |
DE4236707A1 (de) * | 1992-10-30 | 1994-05-05 | Bayer Ag | 4-Heterocyclyl substituierte Dihydropyridine |
US6001857A (en) * | 1992-10-30 | 1999-12-14 | Bayer Aktiengesellschaft | Heterocyclyl substituted dihydropyridines |
PT657432E (pt) | 1993-12-10 | 2003-07-31 | Bayer Ag | 1,4-di-hidropiridinas fenil-substituidas com actividade cerebral |
DE4342193A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester |
EE03192B1 (et) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine |
DE4429786A1 (de) * | 1994-08-23 | 1996-02-29 | Bayer Ag | Verwendung von substituierten 6-Amino-4H-pyranen |
DE19529858A1 (de) * | 1995-08-14 | 1997-02-20 | Bayer Ag | Substituierte 4H-Pyrane |
DE19529859A1 (de) * | 1995-08-14 | 1997-02-20 | Bayer Ag | Verwendung von Acyl-substituierten Aminopyranen |
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
IT1283793B1 (it) * | 1996-08-23 | 1998-04-30 | Lusochimica Spa | Processo per la preparazione di diidropiridine |
US6537504B1 (en) | 1998-04-06 | 2003-03-25 | Li Young | Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds |
US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
ATE268331T1 (de) * | 2000-03-03 | 2004-06-15 | Abbott Lab | Tricyclische dihydropyrazolone und tricyclische dihydroisoaxazolone als kaliumkanalöffner |
CN105669532B (zh) * | 2014-12-03 | 2018-11-02 | 广州市恒诺康医药科技有限公司 | 尼莫地平水溶性衍生物及其制备方法和应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US3932645A (en) * | 1971-04-10 | 1976-01-13 | Farbenfabriken Bayer Ag | Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid |
DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2210674C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
DE2235406C3 (de) * | 1972-07-19 | 1982-01-07 | Bayer Ag, 5090 Leverkusen | 2-Amino-4H-pyrane, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2650013C3 (de) * | 1976-10-30 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
DE2659665A1 (de) * | 1976-12-30 | 1978-07-13 | Nattermann A & Cie | Neue 1,4-dihydropyridin-derivate |
DK149855C (da) * | 1977-06-20 | 1987-04-21 | Sandoz Ag | Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater |
SU740768A1 (ru) * | 1977-11-21 | 1980-06-15 | Институт Органического Синтеза Ан Латвийской Сср | Способ получени эфиров 2,6-диметил1,4-дигидропиридин-3,5-дикарбоновой кислоты |
SU725406A1 (ru) * | 1978-08-08 | 1981-07-30 | Ордена Трудового Красного Знамениинститут Органического Синтеза Ah Латвий-Ской Ccp | Эфиры диметил дигидропиридин диКАРбОНОВОй КиСлОТы,ОблАдАющиЕ АНТи-МЕТАСТАТичЕСКОй АКТиВНОСТью |
JPS5527054A (en) * | 1978-08-15 | 1980-02-26 | Gen Foods Corp | Adsorption method |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4258042A (en) * | 1980-04-11 | 1981-03-24 | Usv Pharmaceutical Corporation | Antihypertensive pyridines and compositions |
DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
DE3042769A1 (de) * | 1980-11-13 | 1982-06-09 | Bayer Ag, 5090 Leverkusen | C-3 verknuepfte 1,4-dihydropyridine, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
-
1982
- 1982-03-10 DE DE19823208628 patent/DE3208628A1/de not_active Withdrawn
-
1983
- 1983-02-21 EP EP83101626A patent/EP0088276B1/de not_active Expired
- 1983-02-21 DE DE8383101626T patent/DE3363244D1/de not_active Expired
- 1983-02-21 AT AT83101626T patent/ATE19513T1/de not_active IP Right Cessation
- 1983-02-22 US US06/468,621 patent/US4622332A/en not_active Expired - Fee Related
- 1983-02-22 NO NO830612A patent/NO830612L/no unknown
- 1983-03-01 PT PT76316A patent/PT76316B/pt unknown
- 1983-03-07 IL IL68075A patent/IL68075A0/xx unknown
- 1983-03-08 AU AU12143/83A patent/AU1214383A/en not_active Abandoned
- 1983-03-08 CA CA000423079A patent/CA1239401A/en not_active Expired
- 1983-03-08 GR GR70727A patent/GR78508B/el unknown
- 1983-03-08 FI FI830776A patent/FI830776L/fi not_active Application Discontinuation
- 1983-03-09 JP JP58037579A patent/JPS58164575A/ja active Pending
- 1983-03-09 DK DK114783A patent/DK114783A/da not_active Application Discontinuation
- 1983-03-09 ES ES520441A patent/ES520441A0/es active Granted
- 1983-03-09 KR KR1019830000953A patent/KR840004074A/ko not_active Application Discontinuation
- 1983-03-09 ZA ZA831633A patent/ZA831633B/xx unknown
- 1983-03-09 PH PH28620A patent/PH20468A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR840004074A (ko) | 1984-10-06 |
CA1239401A (en) | 1988-07-19 |
DK114783A (da) | 1983-09-11 |
PH20468A (en) | 1987-01-14 |
NO830612L (no) | 1983-09-12 |
JPS58164575A (ja) | 1983-09-29 |
ATE19513T1 (de) | 1986-05-15 |
ES8401466A1 (es) | 1983-12-16 |
FI830776L (fi) | 1983-09-11 |
DE3208628A1 (de) | 1983-09-22 |
US4622332A (en) | 1986-11-11 |
DE3363244D1 (en) | 1986-06-05 |
ES520441A0 (es) | 1983-12-16 |
PT76316A (en) | 1983-04-01 |
FI830776A0 (fi) | 1983-03-08 |
EP0088276A1 (de) | 1983-09-14 |
GR78508B (el) | 1984-09-27 |
AU1214383A (en) | 1983-09-15 |
ZA831633B (en) | 1983-12-28 |
DK114783D0 (da) | 1983-03-09 |
PT76316B (en) | 1985-11-25 |
EP0088276B1 (de) | 1986-04-30 |
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