IL65808A - 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them - Google Patents

2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL65808A
IL65808A IL65808A IL6580882A IL65808A IL 65808 A IL65808 A IL 65808A IL 65808 A IL65808 A IL 65808A IL 6580882 A IL6580882 A IL 6580882A IL 65808 A IL65808 A IL 65808A
Authority
IL
Israel
Prior art keywords
sub
integer
hydrogen
formula
phenyl
Prior art date
Application number
IL65808A
Other languages
English (en)
Other versions
IL65808A0 (en
Original Assignee
Merrell Toraude & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude & Co filed Critical Merrell Toraude & Co
Priority to IL7582982A priority Critical patent/IL75829A/xx
Publication of IL65808A0 publication Critical patent/IL65808A0/xx
Publication of IL65808A publication Critical patent/IL65808A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Treatment Of Sludge (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL65808A 1981-06-01 1982-05-17 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them IL65808A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL7582982A IL75829A (en) 1981-06-01 1982-05-17 Alkoxyphenyl compounds and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors

Publications (2)

Publication Number Publication Date
IL65808A0 IL65808A0 (en) 1982-08-31
IL65808A true IL65808A (en) 1986-12-31

Family

ID=23023513

Family Applications (2)

Application Number Title Priority Date Filing Date
IL65808A IL65808A (en) 1981-06-01 1982-05-17 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them
IL75829A IL75829A0 (en) 1981-06-01 1985-07-17 Alkoxyphenyl compounds and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL75829A IL75829A0 (en) 1981-06-01 1985-07-17 Alkoxyphenyl compounds and their preparation

Country Status (18)

Country Link
US (1) US4454158A (fr)
EP (1) EP0067105B1 (fr)
JP (1) JPS5823649A (fr)
KR (1) KR890002756B1 (fr)
AT (1) ATE29875T1 (fr)
AU (2) AU550607B2 (fr)
CA (2) CA1187500A (fr)
DE (1) DE3277371D1 (fr)
DK (1) DK244282A (fr)
ES (4) ES512699A0 (fr)
GB (2) GB2100255B (fr)
GR (1) GR78033B (fr)
IE (1) IE53456B1 (fr)
IL (2) IL65808A (fr)
MX (1) MX9202950A (fr)
NO (1) NO152837C (fr)
NZ (1) NZ200644A (fr)
ZA (1) ZA823633B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
ATE71933T1 (de) * 1985-12-05 1992-02-15 Merrell Dow Pharma Nichtaromatische fluoralkylamin-mao-inhibitoren.
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
AR243493A1 (es) * 1987-06-16 1993-08-31 Merrell Dow Pharma Procedimiento para preparar (e)-2-(p-fluorfenetil)-3-fluoralilamina y sus sales farmaceuticamente aceptables, util como inhibidor de mao-b irreversible y activado por enzimas.
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
AU618076B2 (en) * 1988-02-25 1991-12-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyloxidase
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
JP3273141B2 (ja) * 1995-03-02 2002-04-08 アール． ピー． シェーラー リミテッド モノアミンオキシダーゼｂインヒビターからなる医薬組成物
EP2004166A2 (fr) * 2006-03-31 2008-12-24 La Jolla Pharmaceutical Company Inhibiteurs d'adhérence médiée par l'amine oxydase sensible aux semi-carbazides (ssao) et la vap-1 utilisés dans le traitement et la prévention de maladies
WO2008006761A1 (fr) * 2006-07-13 2008-01-17 Basf Se Azolopyrimidines fongicides, procédés de production associés, leur utilisation pour lutter contre des champignons nuisibles et agents les contenant
WO2009055002A1 (fr) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Inhibiteurs combinés de la cyclooxygénase et de l'amine oxydase sensible au semicarbazide (ssao) (protéine d'adhésion vasculaire, vap-1)
JP2011504485A (ja) 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
CN107266332B (zh) 2012-05-02 2020-07-24 勃林格殷格翰国际有限公司 Ssao的取代的3-卤代烯丙基胺抑制剂及其用途
WO2015087094A1 (fr) * 2013-12-10 2015-06-18 Semmelweis Egyetem Nouveaux dérivés arylalcénylpropargylamine faisant preuve d'action neuroprotectrice pour le traitement des maladies neurodégénératives
AR115906A1 (es) 2018-08-03 2021-03-10 Pharmaxis Ltd Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
ES523874A0 (es) 1985-04-16
ZA823633B (en) 1983-03-30
GB8428858D0 (en) 1984-12-27
NZ200644A (en) 1986-06-11
CA1204759A (fr) 1986-05-20
ES8507461A1 (es) 1985-10-01
ES523875A0 (es) 1985-04-16
IL65808A0 (en) 1982-08-31
ES8402810A1 (es) 1984-03-01
EP0067105A3 (en) 1984-02-22
JPH0422898B2 (fr) 1992-04-20
IL75829A0 (en) 1985-11-29
NO821799L (no) 1982-12-02
AU8423882A (en) 1983-02-03
ATE29875T1 (de) 1987-10-15
ES523873A0 (es) 1985-10-01
US4454158B1 (fr) 1992-12-22
AU550607B2 (en) 1986-03-27
ES8503638A1 (es) 1985-04-16
KR890002756B1 (ko) 1989-07-27
IE53456B1 (en) 1988-11-23
DK244282A (da) 1982-12-02
KR830010044A (ko) 1983-12-24
GB2152039A (en) 1985-07-31
NO152837C (no) 1985-11-27
NO152837B (no) 1985-08-19
GR78033B (fr) 1984-09-26
JPS5823649A (ja) 1983-02-12
DE3277371D1 (en) 1987-10-29
US4454158A (en) 1984-06-12
MX9202950A (es) 1992-07-01
GB2100255B (en) 1985-10-23
GB2152039B (en) 1986-04-30
GB2100255A (en) 1982-12-22
CA1187500A (fr) 1985-05-21
EP0067105B1 (fr) 1987-09-23
EP0067105A2 (fr) 1982-12-15
AU5180586A (en) 1986-06-12
IE821246L (en) 1982-12-01
ES8503639A1 (es) 1985-04-16
AU576281B2 (en) 1988-08-18
ES512699A0 (es) 1984-03-01

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Legal Events

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KB Patent renewed
RH Patent void