IL62378A - Pharmaceutical compositions comprising vlb(and desacetyl vlb)3-(2-chloroethyl)carboxamide derivatives for treating neoplasms,some new such derivatives and their preparation - Google Patents

Pharmaceutical compositions comprising vlb(and desacetyl vlb)3-(2-chloroethyl)carboxamide derivatives for treating neoplasms,some new such derivatives and their preparation

Info

Publication number
IL62378A
IL62378A IL62378A IL6237881A IL62378A IL 62378 A IL62378 A IL 62378A IL 62378 A IL62378 A IL 62378A IL 6237881 A IL6237881 A IL 6237881A IL 62378 A IL62378 A IL 62378A
Authority
IL
Israel
Prior art keywords
vlb
derivatives
chloroethyl
preparation
new
Prior art date
Application number
IL62378A
Other languages
English (en)
Other versions
IL62378A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL62378A0 publication Critical patent/IL62378A0/xx
Publication of IL62378A publication Critical patent/IL62378A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL62378A 1980-03-20 1981-03-16 Pharmaceutical compositions comprising vlb(and desacetyl vlb)3-(2-chloroethyl)carboxamide derivatives for treating neoplasms,some new such derivatives and their preparation IL62378A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/132,246 US4357334A (en) 1980-03-20 1980-03-20 Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms

Publications (2)

Publication Number Publication Date
IL62378A0 IL62378A0 (en) 1981-05-20
IL62378A true IL62378A (en) 1984-03-30

Family

ID=22453135

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62378A IL62378A (en) 1980-03-20 1981-03-16 Pharmaceutical compositions comprising vlb(and desacetyl vlb)3-(2-chloroethyl)carboxamide derivatives for treating neoplasms,some new such derivatives and their preparation

Country Status (28)

Country Link
US (1) US4357334A (ko)
EP (1) EP0036762B1 (ko)
JP (1) JPS56145293A (ko)
KR (1) KR840002146B1 (ko)
AR (1) AR228863A1 (ko)
AT (1) ATE9761T1 (ko)
AU (1) AU539564B2 (ko)
BG (1) BG36200A3 (ko)
CA (1) CA1159055A (ko)
DD (1) DD157558A5 (ko)
DE (1) DE3166544D1 (ko)
DK (1) DK124281A (ko)
EG (1) EG15247A (ko)
ES (2) ES500536A0 (ko)
FI (1) FI810856L (ko)
GB (1) GB2072184B (ko)
GR (1) GR73870B (ko)
HU (1) HU185247B (ko)
IE (1) IE51034B1 (ko)
IL (1) IL62378A (ko)
NZ (1) NZ196511A (ko)
PH (1) PH16213A (ko)
PL (1) PL230226A1 (ko)
PT (1) PT72695B (ko)
RO (2) RO85813B (ko)
SU (2) SU1017172A3 (ko)
YU (1) YU66281A (ko)
ZA (1) ZA811733B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124502B1 (fr) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Nouveaux conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques contenant ces conjugués
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (ko) 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4160767A (en) * 1976-12-06 1979-07-10 Eli Lilly And Company Vinca alkaloid intermediates
US4191688A (en) * 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
SU1200851A3 (ru) 1985-12-23
FI810856L (fi) 1981-09-21
ES8302009A1 (es) 1982-12-16
IE810609L (en) 1981-09-20
AU539564B2 (en) 1984-10-04
GR73870B (ko) 1984-05-09
AR228863A1 (es) 1983-04-29
ES8206538A1 (es) 1982-08-16
PT72695A (en) 1981-04-01
US4357334A (en) 1982-11-02
DK124281A (da) 1981-09-21
IE51034B1 (en) 1986-09-17
DD157558A5 (de) 1982-11-17
GB2072184A (en) 1981-09-30
EG15247A (en) 1986-03-31
EP0036762A2 (en) 1981-09-30
HU185247B (en) 1984-12-28
SU1017172A3 (ru) 1983-05-07
AU6858181A (en) 1981-09-24
PT72695B (en) 1982-03-24
JPS56145293A (en) 1981-11-11
ES509581A0 (es) 1982-12-16
RO85813B (ro) 1984-11-30
YU66281A (en) 1983-10-31
KR840002146B1 (ko) 1984-11-23
ES500536A0 (es) 1982-08-16
CA1159055A (en) 1983-12-20
EP0036762B1 (en) 1984-10-10
ZA811733B (en) 1982-10-27
RO82171B (ro) 1983-06-30
BG36200A3 (en) 1984-09-14
KR830005248A (ko) 1983-08-03
RO82171A (ro) 1983-07-07
RO85813A (ro) 1984-11-25
GB2072184B (en) 1984-01-11
ATE9761T1 (de) 1984-10-15
DE3166544D1 (en) 1984-11-15
IL62378A0 (en) 1981-05-20
EP0036762A3 (en) 1981-10-07
NZ196511A (en) 1983-09-30
PL230226A1 (ko) 1982-03-15
PH16213A (en) 1983-08-05

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