IL61332A - 1 alpha-methyl-17 alpha-alkyl-5 alpha-androstanes,pharmaceutical preparations containing them and process for their manufacture - Google Patents
1 alpha-methyl-17 alpha-alkyl-5 alpha-androstanes,pharmaceutical preparations containing them and process for their manufactureInfo
- Publication number
- IL61332A IL61332A IL61332A IL6133280A IL61332A IL 61332 A IL61332 A IL 61332A IL 61332 A IL61332 A IL 61332A IL 6133280 A IL6133280 A IL 6133280A IL 61332 A IL61332 A IL 61332A
- Authority
- IL
- Israel
- Prior art keywords
- alpha
- alkyl
- alkenyl
- androstanes
- methyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 206010039792 Seborrhoea Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0044—Alkenyl derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792943776 DE2943776A1 (de) | 1979-10-26 | 1979-10-26 | 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL61332A0 IL61332A0 (en) | 1980-12-31 |
| IL61332A true IL61332A (en) | 1985-05-31 |
Family
ID=6084722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL61332A IL61332A (en) | 1979-10-26 | 1980-10-23 | 1 alpha-methyl-17 alpha-alkyl-5 alpha-androstanes,pharmaceutical preparations containing them and process for their manufacture |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US4344941A (enExample) |
| EP (1) | EP0027961B1 (enExample) |
| JP (1) | JPS5673097A (enExample) |
| AT (1) | ATE2221T1 (enExample) |
| AU (1) | AU532515B2 (enExample) |
| CA (1) | CA1160216A (enExample) |
| CS (1) | CS228507B2 (enExample) |
| DD (1) | DD153694A5 (enExample) |
| DE (2) | DE2943776A1 (enExample) |
| DK (1) | DK163002C (enExample) |
| EG (1) | EG14998A (enExample) |
| ES (1) | ES8106539A1 (enExample) |
| FI (1) | FI69850C (enExample) |
| GR (1) | GR71212B (enExample) |
| HU (1) | HU183237B (enExample) |
| IE (1) | IE52686B1 (enExample) |
| IL (1) | IL61332A (enExample) |
| NO (1) | NO154231C (enExample) |
| PL (1) | PL125169B1 (enExample) |
| PT (1) | PT71842B (enExample) |
| SU (1) | SU973025A3 (enExample) |
| YU (1) | YU256680A (enExample) |
| ZA (1) | ZA806565B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2943776A1 (de) * | 1979-10-26 | 1981-05-14 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung |
| DE3115996A1 (de) * | 1981-04-13 | 1982-11-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 17(alpha)-alkyl-17(beta)-hydroxy-1(alpha)- methyl-4-androsten-3-one-.verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten |
| DE3322285A1 (de) * | 1983-06-18 | 1984-12-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US4885289A (en) * | 1983-12-12 | 1989-12-05 | Breuer Miklos M | Alteration of character of male beard growth |
| US5714510A (en) * | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical proxyl composition and method |
| US5472687A (en) * | 1985-07-18 | 1995-12-05 | Proctor; Peter H. | Topical pyridine N-oxides |
| US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
| US5714482A (en) * | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical spin labels and method |
| US5716947A (en) * | 1985-07-18 | 1998-02-10 | Proctor; Peter H. | Topical doxyl composition and method |
| US5470876A (en) * | 1985-07-18 | 1995-11-28 | Proctor; Peter H. | Topical sod for treating hair loss |
| US6150405A (en) * | 1985-07-18 | 2000-11-21 | Proctor; Peter H. | Hair loss treatment with ascorbates |
| US5728714A (en) * | 1985-07-18 | 1998-03-17 | Proctor; Peter H. | Method for treating hair loss using tempo |
| US5352442A (en) * | 1985-07-18 | 1994-10-04 | Proctor Peter H | Topical tempo |
| US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
| DE3824247A1 (de) * | 1988-07-13 | 1990-01-18 | Schering Ag | Neue androstan-derivate |
| EP0499779B1 (de) * | 1991-01-24 | 1996-09-11 | Rheinbraun Aktiengesellschaft | Verfahren zum Behandeln von Abfällen |
| US5328686A (en) * | 1991-10-30 | 1994-07-12 | Douglas Shander | Treatment of acne or of pseudofolliculitis barbae |
| EP0612211B1 (en) * | 1991-11-05 | 2002-06-05 | The Gillette Company | Alteration of rate and character of hair growth |
| US5364885A (en) * | 1992-11-13 | 1994-11-15 | Ahluwalia Gurpreet S | Reduction of hair growth |
| US6743419B1 (en) | 1992-12-22 | 2004-06-01 | The Gillette Company | Method of reducing hair growth employing sulfhydryl active compounds |
| US5411991A (en) * | 1992-12-22 | 1995-05-02 | Shander; Douglas | Method of reducing hair growth employing sulfhydryl active compounds |
| US5648394A (en) * | 1993-05-27 | 1997-07-15 | Boxall; Brian Alfred | Topical composition for inhibiting hair growth |
| US6248751B1 (en) | 1993-05-28 | 2001-06-19 | Gurpreet S. Ahluwalia | Inhibition of hair growth |
| US6414017B2 (en) | 1993-05-28 | 2002-07-02 | The Gillette Company | Inhibition of hair growth |
| DE69519368T2 (de) * | 1994-01-06 | 2001-03-08 | Sri International, Menlo Park | Neue antiandrogenen mitteln pharmazeutische präparate und verwendungen davon |
| US5474763A (en) * | 1994-03-11 | 1995-12-12 | Shander; Douglas | Reduction of hair growth |
| US5468476A (en) * | 1994-03-16 | 1995-11-21 | Ahluwalia; Gurpreet S. | Reduction of hair growth |
| US5455234A (en) * | 1994-03-16 | 1995-10-03 | Ahluwalia; Gurpreet S. | Inhibition of hair growth |
| ES2175084T3 (es) * | 1995-02-28 | 2002-11-16 | Gillette Co | Uso de supresores de angiogenesis para inhibir el crecimiento del pelo. |
| US5674477A (en) * | 1995-02-28 | 1997-10-07 | Ahluwalia; Gurpreet S. | Reduction of hair growth |
| US5728736A (en) * | 1995-11-29 | 1998-03-17 | Shander; Douglas | Reduction of hair growth |
| US5652273A (en) * | 1995-11-30 | 1997-07-29 | Henry; James | Reduction of hair growth |
| US6372712B1 (en) | 1998-05-22 | 2002-04-16 | The Board Of Trustees Of The Leland Stanford Jr. University | Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand |
| US6294188B1 (en) | 1998-07-09 | 2001-09-25 | Aviana Biopharm Inc. | Methods involving changing the constitutive and stimulated secretions of the local reproductive system of women |
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
| AU7736300A (en) * | 1999-09-30 | 2001-04-30 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
| US7285109B2 (en) * | 2003-02-13 | 2007-10-23 | Boston Scientific Scimed, Inc. | Device and method for collapsing an angioplasty balloon |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1382468A (fr) * | 1964-01-28 | 1964-12-18 | Spofa Vereinigte Pharma Werke | Procédé de préparation des composés de 3-céto-androstane 1-méthyle-substitués, et produits conformes à ceux obtenus par le présent procédé ou procédé similaire |
| US3391168A (en) * | 1965-08-23 | 1968-07-02 | Searle & Co | 1, 17-dimethyl-5-androstane-3beta, 17beta-diol and esters thereof |
| US3705180A (en) * | 1971-09-02 | 1972-12-05 | Paul D Klimstra | 17-oxygenate-2-alpha-methyl-2-methylen-5 alpha-androstan-3-ones and intermediates |
| US4039669A (en) * | 1975-08-01 | 1977-08-02 | Sterling Drug Inc. | Composition for topical application and use thereof |
| DE2943776A1 (de) * | 1979-10-26 | 1981-05-14 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung |
-
1979
- 1979-10-26 DE DE19792943776 patent/DE2943776A1/de not_active Withdrawn
-
1980
- 1980-09-26 PT PT71842A patent/PT71842B/pt unknown
- 1980-10-07 YU YU02566/80A patent/YU256680A/xx unknown
- 1980-10-08 ES ES495740A patent/ES8106539A1/es not_active Expired
- 1980-10-09 SU SU802989151A patent/SU973025A3/ru active
- 1980-10-14 DK DK434380A patent/DK163002C/da not_active IP Right Cessation
- 1980-10-16 AT AT80106289T patent/ATE2221T1/de not_active IP Right Cessation
- 1980-10-16 EP EP80106289A patent/EP0027961B1/de not_active Expired
- 1980-10-16 DE DE8080106289T patent/DE3061638D1/de not_active Expired
- 1980-10-20 US US06/198,383 patent/US4344941A/en not_active Expired - Lifetime
- 1980-10-22 DD DD80224695A patent/DD153694A5/de not_active IP Right Cessation
- 1980-10-23 AU AU63637/80A patent/AU532515B2/en not_active Ceased
- 1980-10-23 IL IL61332A patent/IL61332A/xx not_active IP Right Cessation
- 1980-10-23 PL PL1980227468A patent/PL125169B1/pl unknown
- 1980-10-24 HU HU802577A patent/HU183237B/hu not_active IP Right Cessation
- 1980-10-24 IE IE2202/80A patent/IE52686B1/en not_active IP Right Cessation
- 1980-10-24 GR GR63214A patent/GR71212B/el unknown
- 1980-10-24 FI FI803342A patent/FI69850C/fi not_active IP Right Cessation
- 1980-10-24 ZA ZA00806565A patent/ZA806565B/xx unknown
- 1980-10-24 NO NO803172A patent/NO154231C/no unknown
- 1980-10-26 EG EG651/80A patent/EG14998A/xx active
- 1980-10-27 CA CA000363342A patent/CA1160216A/en not_active Expired
- 1980-10-27 JP JP14949780A patent/JPS5673097A/ja active Granted
- 1980-10-27 CS CS807263A patent/CS228507B2/cs unknown
-
1982
- 1982-05-20 US US06/380,328 patent/US4456600A/en not_active Expired - Lifetime
-
1984
- 1984-06-13 US US06/620,216 patent/US4558041A/en not_active Expired - Fee Related
-
1986
- 1986-10-14 US US06/918,231 patent/US4892867A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |