ES8106539A1 - Procedimiento para la preparacion de 17x -alcohilesteroides - Google Patents

Procedimiento para la preparacion de 17x -alcohilesteroides

Info

Publication number
ES8106539A1
ES8106539A1 ES495740A ES495740A ES8106539A1 ES 8106539 A1 ES8106539 A1 ES 8106539A1 ES 495740 A ES495740 A ES 495740A ES 495740 A ES495740 A ES 495740A ES 8106539 A1 ES8106539 A1 ES 8106539A1
Authority
ES
Spain
Prior art keywords
alpha
production
preparations containing
substituted steroids
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495740A
Other languages
English (en)
Other versions
ES495740A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8106539A1 publication Critical patent/ES8106539A1/es
Publication of ES495740A0 publication Critical patent/ES495740A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0044—Alkenyl derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 17-X-ALCOHILESTEROIDES. SE HACE REACCIONAR UN 17-CETOESTERO DE FORMULA (I) CON UN COMPUESTO ORGANOMETALICO QUE DESPRENDE EL RADICAL R2 Y QUE SEPARA EL GRUPO PROTECTOR EN POSICION 3. OPCIONALMENTE SE ESTERIFICA O TERIFICA EL GRUPO 17-HIDROXI ANTES O DESPUES DE LOS GRUPOS PROTECTORES Y/O SE REDUCE EL GRUPO 3-CETO, Y EVENTUALMENTE, A CONTINUACION, SE ESTERIFICAN O ETIRIFICAN GRUPOS HIDROXI LIBRES EN POSICION 3 O EN POSICION 3 Y 17. SE OBTIENE EL COMPUESTO (II). *FORMULA* ACTIVIDAD ANDROGENA.
ES495740A 1979-10-26 1980-10-08 Procedimiento para la preparacion de 17x -alcohilesteroides Granted ES495740A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792943776 DE2943776A1 (de) 1979-10-26 1979-10-26 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8106539A1 true ES8106539A1 (es) 1981-06-16
ES495740A0 ES495740A0 (es) 1981-06-16

Family

ID=6084722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495740A Granted ES495740A0 (es) 1979-10-26 1980-10-08 Procedimiento para la preparacion de 17x -alcohilesteroides

Country Status (23)

Country Link
US (4) US4344941A (es)
EP (1) EP0027961B1 (es)
JP (1) JPS5673097A (es)
AT (1) ATE2221T1 (es)
AU (1) AU532515B2 (es)
CA (1) CA1160216A (es)
CS (1) CS228507B2 (es)
DD (1) DD153694A5 (es)
DE (2) DE2943776A1 (es)
DK (1) DK163002C (es)
EG (1) EG14998A (es)
ES (1) ES495740A0 (es)
FI (1) FI69850C (es)
GR (1) GR71212B (es)
HU (1) HU183237B (es)
IE (1) IE52686B1 (es)
IL (1) IL61332A (es)
NO (1) NO154231C (es)
PL (1) PL125169B1 (es)
PT (1) PT71842B (es)
SU (1) SU973025A3 (es)
YU (1) YU256680A (es)
ZA (1) ZA806565B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2943776A1 (de) * 1979-10-26 1981-05-14 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
DE3115996A1 (de) * 1981-04-13 1982-11-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen 17(alpha)-alkyl-17(beta)-hydroxy-1(alpha)- methyl-4-androsten-3-one-.verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4885289A (en) * 1983-12-12 1989-12-05 Breuer Miklos M Alteration of character of male beard growth
US5714510A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical proxyl composition and method
US5470876A (en) * 1985-07-18 1995-11-28 Proctor; Peter H. Topical sod for treating hair loss
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5728714A (en) * 1985-07-18 1998-03-17 Proctor; Peter H. Method for treating hair loss using tempo
US5714482A (en) * 1985-07-18 1998-02-03 Proctor; Peter H. Topical spin labels and method
US6150405A (en) * 1985-07-18 2000-11-21 Proctor; Peter H. Hair loss treatment with ascorbates
US5716947A (en) * 1985-07-18 1998-02-10 Proctor; Peter H. Topical doxyl composition and method
US5472687A (en) * 1985-07-18 1995-12-05 Proctor; Peter H. Topical pyridine N-oxides
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
DE3824247A1 (de) * 1988-07-13 1990-01-18 Schering Ag Neue androstan-derivate
DE59207073D1 (de) * 1991-01-24 1996-10-17 Rheinische Braunkohlenw Ag Verfahren zum Behandeln von Abfällen
US5328686A (en) * 1991-10-30 1994-07-12 Douglas Shander Treatment of acne or of pseudofolliculitis barbae
EP0612211B1 (en) * 1991-11-05 2002-06-05 The Gillette Company Alteration of rate and character of hair growth
US5364885A (en) * 1992-11-13 1994-11-15 Ahluwalia Gurpreet S Reduction of hair growth
US5411991A (en) * 1992-12-22 1995-05-02 Shander; Douglas Method of reducing hair growth employing sulfhydryl active compounds
US6743419B1 (en) 1992-12-22 2004-06-01 The Gillette Company Method of reducing hair growth employing sulfhydryl active compounds
US5648394A (en) * 1993-05-27 1997-07-15 Boxall; Brian Alfred Topical composition for inhibiting hair growth
US6414017B2 (en) 1993-05-28 2002-07-02 The Gillette Company Inhibition of hair growth
US6248751B1 (en) 1993-05-28 2001-06-19 Gurpreet S. Ahluwalia Inhibition of hair growth
DE69519368T2 (de) * 1994-01-06 2001-03-08 Stanford Res Inst Int Neue antiandrogenen mitteln pharmazeutische präparate und verwendungen davon
US5474763A (en) * 1994-03-11 1995-12-12 Shander; Douglas Reduction of hair growth
US5468476A (en) * 1994-03-16 1995-11-21 Ahluwalia; Gurpreet S. Reduction of hair growth
US5455234A (en) * 1994-03-16 1995-10-03 Ahluwalia; Gurpreet S. Inhibition of hair growth
US5674477A (en) * 1995-02-28 1997-10-07 Ahluwalia; Gurpreet S. Reduction of hair growth
ES2175084T3 (es) * 1995-02-28 2002-11-16 Gillette Co Uso de supresores de angiogenesis para inhibir el crecimiento del pelo.
US5728736A (en) * 1995-11-29 1998-03-17 Shander; Douglas Reduction of hair growth
US5652273A (en) 1995-11-30 1997-07-29 Henry; James Reduction of hair growth
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
US6294188B1 (en) 1998-07-09 2001-09-25 Aviana Biopharm Inc. Methods involving changing the constitutive and stimulated secretions of the local reproductive system of women
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
DE60045751D1 (de) 1999-09-30 2011-04-28 Harbor Biosciences Inc Therapeutische Behandlung androgenrezeptorbedingter Leiden
US7285109B2 (en) * 2003-02-13 2007-10-23 Boston Scientific Scimed, Inc. Device and method for collapsing an angioplasty balloon
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1382468A (fr) * 1964-01-28 1964-12-18 Spofa Vereinigte Pharma Werke Procédé de préparation des composés de 3-céto-androstane 1-méthyle-substitués, et produits conformes à ceux obtenus par le présent procédé ou procédé similaire
US3391168A (en) * 1965-08-23 1968-07-02 Searle & Co 1, 17-dimethyl-5-androstane-3beta, 17beta-diol and esters thereof
US3705180A (en) * 1971-09-02 1972-12-05 Paul D Klimstra 17-oxygenate-2-alpha-methyl-2-methylen-5 alpha-androstan-3-ones and intermediates
US4039669A (en) * 1975-08-01 1977-08-02 Sterling Drug Inc. Composition for topical application and use thereof
DE2943776A1 (de) * 1979-10-26 1981-05-14 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NO154231B (no) 1986-05-05
IL61332A (en) 1985-05-31
HU183237B (en) 1984-04-28
DD153694A5 (de) 1982-01-27
DE3061638D1 (en) 1983-02-17
SU973025A3 (ru) 1982-11-07
NO803172L (no) 1981-04-27
AU532515B2 (en) 1983-10-06
FI803342L (fi) 1981-04-27
DK163002C (da) 1992-06-01
PL227468A1 (es) 1981-07-10
PT71842B (de) 1981-07-09
FI69850B (fi) 1985-12-31
EP0027961A1 (de) 1981-05-06
JPS5673097A (en) 1981-06-17
US4892867A (en) 1990-01-09
GR71212B (es) 1983-04-11
IE802202L (en) 1981-04-26
ZA806565B (en) 1981-10-28
DK434380A (da) 1981-04-27
US4456600A (en) 1984-06-26
FI69850C (fi) 1986-05-26
IL61332A0 (en) 1980-12-31
ES495740A0 (es) 1981-06-16
US4558041A (en) 1985-12-10
US4344941A (en) 1982-08-17
CS228507B2 (en) 1984-05-14
ATE2221T1 (de) 1983-01-15
PL125169B1 (en) 1983-04-30
DK163002B (da) 1992-01-06
NO154231C (no) 1986-08-13
EP0027961B1 (de) 1983-01-12
AU6363780A (en) 1981-04-30
DE2943776A1 (de) 1981-05-14
EG14998A (en) 1985-06-30
YU256680A (en) 1983-02-28
JPH0153280B2 (es) 1989-11-13
PT71842A (de) 1980-10-01
IE52686B1 (en) 1988-01-20
CA1160216A (en) 1984-01-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401