IL41619A - N-propanolamine sites and their preparation - Google Patents
N-propanolamine sites and their preparationInfo
- Publication number
- IL41619A IL41619A IL41619A IL4161973A IL41619A IL 41619 A IL41619 A IL 41619A IL 41619 A IL41619 A IL 41619A IL 4161973 A IL4161973 A IL 4161973A IL 41619 A IL41619 A IL 41619A
- Authority
- IL
- Israel
- Prior art keywords
- group
- ether
- phenyl
- general formula
- isobutyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7207647A FR2174655B1 (de) | 1972-03-06 | 1972-03-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41619A0 IL41619A0 (en) | 1973-04-30 |
| IL41619A true IL41619A (en) | 1976-05-31 |
Family
ID=9094658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41619A IL41619A (en) | 1972-03-06 | 1973-02-26 | N-propanolamine sites and their preparation |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US3962238A (de) |
| JP (1) | JPS4899127A (de) |
| BE (1) | BE795735A (de) |
| CA (2) | CA1015360A (de) |
| CH (1) | CH556815A (de) |
| DE (1) | DE2310918C3 (de) |
| ES (1) | ES412203A1 (de) |
| FR (1) | FR2174655B1 (de) |
| GB (1) | GB1377327A (de) |
| IL (1) | IL41619A (de) |
| NL (1) | NL153190C (de) |
| ZA (1) | ZA731411B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2378024A1 (fr) * | 1977-01-25 | 1978-08-18 | Cerm Cent Europ Rech Mauvernay | Nouvelle propylamine substituee, obtention et application |
| FR2472567A1 (fr) | 1979-12-28 | 1981-07-03 | Cerm Cent Europ Rech Mauvernay | Ethers de 1- (2-propynyloxy)-2-amino-3-propanol, leur preparation et leur application en therapeutique |
| WO1983002274A1 (en) * | 1981-12-28 | 1983-07-07 | Carter Wallace | Synthesis of 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolidino hydrochloride |
| US4405583A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 using di-severely sterically hindered secondary aminoethers |
| US4483833A (en) * | 1982-01-18 | 1984-11-20 | Exxon Research & Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 with heterocyclic tertiary aminoalkanols |
| US4405582A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 using diaminoether solutions |
| US4417075A (en) * | 1982-01-18 | 1983-11-22 | Exxon Research And Engineering Co. | Di-(Secondary and tertiaryalkylaminoalkoxy)alkanes |
| US4471138A (en) * | 1982-01-18 | 1984-09-11 | Exxon Research And Engineering Co. | Severely sterically hindered secondary aminoether alcohols |
| US4405580A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for selective removal of H2 S from mixtures containing H22 with tertiary amino azabicyclic alcohols |
| US4405811A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Severely sterically hindered tertiary amino compounds |
| US4405581A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary amino compounds |
| US4762934A (en) * | 1982-01-18 | 1988-08-09 | Exxon Research And Engineering Company | Diaminoether compositions |
| US4405585A (en) * | 1982-01-18 | 1983-09-20 | Exxon Research And Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary aminoether alcohols |
| US4508692A (en) * | 1982-01-18 | 1985-04-02 | Exxon Research & Engineering Co. | Process for the selective removal of hydrogen sulfide from gaseous mixtures with strongly basic tertiary amino compounds |
| DK156396C (da) * | 1983-09-27 | 1990-01-08 | Cerm Cent Europ Rech Mauvernay | 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse |
| AU568704B2 (en) * | 1983-11-11 | 1988-01-07 | Akzo N.V. | Ether of n-propanolamine derivative |
| GB8330197D0 (en) * | 1983-11-11 | 1983-12-21 | Akzo Nv | Ether of n-propanolamine derivative |
| US4727072A (en) * | 1986-02-12 | 1988-02-23 | Mcneilab, Inc. | 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents |
| US4758563A (en) * | 1986-02-12 | 1988-07-19 | Mcneilab, Inc. | 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use |
| DE3726633A1 (de) * | 1987-08-11 | 1989-02-23 | Boehringer Mannheim Gmbh | Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| DE3726632A1 (de) * | 1987-08-11 | 1989-05-18 | Boehringer Mannheim Gmbh | 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US4888335A (en) | 1988-07-25 | 1989-12-19 | Mcneilab, Inc. | 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents |
| US5185362A (en) * | 1988-09-14 | 1993-02-09 | Mcneilab, Inc. | Diphenylamine cardiovascular agents, compositions and use |
| GEP20074134B (en) | 2002-08-19 | 2007-06-25 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases |
| NZ543741A (en) * | 2003-05-30 | 2009-10-30 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| RU2007106714A (ru) * | 2004-07-26 | 2008-09-10 | Байер Шеринг Фарма Аг (De) | Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц |
| ATE439347T1 (de) * | 2004-11-23 | 2009-08-15 | Warner Lambert Co | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (de) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie |
| EP2111863B1 (de) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Fasudil in Kombination mit Bosentan zur Behandlung von pulmonaler arterieller Hypertonie |
| US8026377B2 (en) * | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
| WO2008010087A2 (en) * | 2006-07-14 | 2008-01-24 | Ranbaxy Laboratories Limited | Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| WO2009032286A2 (en) | 2007-09-06 | 2009-03-12 | Nektar Therapeutics Al, Corporation | Oligomer-calcium channel blocker conjugates |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| SG11201507496UA (en) | 2013-04-17 | 2015-11-27 | Pfizer | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| WO2016098128A1 (en) | 2014-12-16 | 2016-06-23 | Council Of Scientific & Industrial Research | Process for the preparation of bepridil |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH268689A (de) * | 1947-07-01 | 1950-05-31 | Spojene Farmaceuticke Z Narodn | Verfahren zur Darstellung eines biologisch wirksamen Phenyläthylendiaminderivates. |
| US2600301A (en) * | 1948-06-04 | 1952-06-10 | Smith Kline French Lab | N-substituted-beta halo-ethyl amines |
| BE546290A (de) * | 1955-04-09 | |||
| GB1219609A (en) * | 1968-07-19 | 1971-01-20 | Koninklijke Pharma Fab Nv | Diphenylmethoxyethylamino derivatives |
-
0
- BE BE795735D patent/BE795735A/xx unknown
-
1972
- 1972-03-06 FR FR7207647A patent/FR2174655B1/fr not_active Expired
-
1973
- 1973-02-20 CH CH270373A patent/CH556815A/fr not_active IP Right Cessation
- 1973-02-26 IL IL41619A patent/IL41619A/en unknown
- 1973-02-27 US US05/336,357 patent/US3962238A/en not_active Expired - Lifetime
- 1973-02-28 ZA ZA731411A patent/ZA731411B/xx unknown
- 1973-03-01 JP JP48024754A patent/JPS4899127A/ja active Pending
- 1973-03-01 ES ES412203A patent/ES412203A1/es not_active Expired
- 1973-03-02 GB GB1037973A patent/GB1377327A/en not_active Expired
- 1973-03-05 DE DE2310918A patent/DE2310918C3/de not_active Expired
- 1973-03-06 CA CA165,544A patent/CA1015360A/fr not_active Expired
- 1973-03-06 NL NL7303117.A patent/NL153190C/xx not_active IP Right Cessation
-
1978
- 1978-05-30 CA CA304,367A patent/CA1048027A/fr not_active Expired
-
1979
- 1979-02-27 US US06/015,752 patent/USRE30577E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2310918A1 (de) | 1973-09-20 |
| US3962238A (en) | 1976-06-08 |
| USRE30577E (en) | 1981-04-14 |
| FR2174655A1 (de) | 1973-10-19 |
| CA1048027A (fr) | 1979-02-06 |
| CH556815A (fr) | 1974-12-13 |
| DE2310918C3 (de) | 1980-07-03 |
| CA1015360A (fr) | 1977-08-09 |
| IL41619A0 (en) | 1973-04-30 |
| BE795735A (fr) | 1973-06-18 |
| NL7303117A (de) | 1973-09-10 |
| NL153190B (nl) | 1977-05-16 |
| FR2174655B1 (de) | 1975-08-01 |
| JPS4899127A (de) | 1973-12-15 |
| GB1377327A (en) | 1974-12-11 |
| ZA731411B (en) | 1974-04-24 |
| NL153190C (nl) | 1980-12-15 |
| ES412203A1 (es) | 1975-12-01 |
| DE2310918B2 (de) | 1979-10-25 |
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