IL41198A - 1 - Phenyl - H3 - 1, 4 - Benzodiazepine - H1, H) - 5, 42 (- Diones, their preparation and pharmaceutical preparations containing them - Google Patents
1 - Phenyl - H3 - 1, 4 - Benzodiazepine - H1, H) - 5, 42 (- Diones, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL41198A IL41198A IL41198A IL4119872A IL41198A IL 41198 A IL41198 A IL 41198A IL 41198 A IL41198 A IL 41198A IL 4119872 A IL4119872 A IL 4119872A IL 41198 A IL41198 A IL 41198A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- compounds
- group
- chlorine
- phenyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 229910021529 ammonia Inorganic materials 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229910052740 iodine Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- -1 nitro, amino Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000002048 spasmolytic effect Effects 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2165311A DE2165311A1 (de) | 1971-12-29 | 1971-12-29 | Neue 1-aryl-3h-1,4-benzodiazepin2,5-(1h,4h)-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41198A0 IL41198A0 (en) | 1973-02-28 |
| IL41198A true IL41198A (en) | 1976-08-31 |
Family
ID=5829591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41198A IL41198A (en) | 1971-12-29 | 1972-12-28 | 1 - Phenyl - H3 - 1, 4 - Benzodiazepine - H1, H) - 5, 42 (- Diones, their preparation and pharmaceutical preparations containing them |
Country Status (23)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK171349B1 (da) * | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
| RU2687556C1 (ru) * | 2018-12-24 | 2019-05-15 | Акционерное общество "Федеральный научно-производственный центр "Алтай" | Способ получения 7-хлор-1,3-дигидро-1-метил-5-фенил-2Н-1,4-бензодиазепин-2-она |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT280290B (de) * | 1967-11-24 | 1970-04-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen 1-Phenyl-4-alkyl-3H-1,4-benzodiazepin-2,5-[1H,4H]-dionen |
-
0
- BE BE793460D patent/BE793460A/xx unknown
-
1971
- 1971-12-29 DE DE2165311A patent/DE2165311A1/de active Pending
-
1972
- 1972-12-19 AT AT1080772A patent/AT327912B/de not_active IP Right Cessation
- 1972-12-19 AT AT228574*1A patent/AT324345B/de not_active IP Right Cessation
- 1972-12-19 RO RO7200073207A patent/RO62852A/ro unknown
- 1972-12-20 SU SU1955543A patent/SU461502A3/ru active
- 1972-12-20 SU SU1860137*7A patent/SU452098A3/ru active
- 1972-12-21 DK DK641872AA patent/DK129655B/da unknown
- 1972-12-26 BG BG025578A patent/BG20375A3/xx unknown
- 1972-12-26 BG BG022240A patent/BG19805A3/xx unknown
- 1972-12-26 JP JP47129704A patent/JPS4885587A/ja active Pending
- 1972-12-27 CH CH250676A patent/CH583208A5/xx not_active IP Right Cessation
- 1972-12-27 ES ES410057A patent/ES410057A1/es not_active Expired
- 1972-12-27 DD DD168055*A patent/DD106384A5/xx unknown
- 1972-12-27 CH CH1887672A patent/CH587830A5/xx not_active IP Right Cessation
- 1972-12-27 ZA ZA729073A patent/ZA729073B/xx unknown
- 1972-12-28 GB GB5988172A patent/GB1395772A/en not_active Expired
- 1972-12-28 CA CA160,145A patent/CA1028702A/en not_active Expired
- 1972-12-28 NO NO4808/72A patent/NO138089C/no unknown
- 1972-12-28 SE SE7217089A patent/SE405120B/xx unknown
- 1972-12-28 PL PL1972159831A patent/PL85284B1/pl unknown
- 1972-12-28 FI FI3686/72A patent/FI54920C/fi active
- 1972-12-28 HU HUBO5306A patent/HU165306B/hu unknown
- 1972-12-28 IL IL41198A patent/IL41198A/en unknown
- 1972-12-28 PL PL1972175731A patent/PL84244B1/pl unknown
- 1972-12-29 FR FR7247013A patent/FR2166204B1/fr not_active Expired
- 1972-12-29 IE IE1805/72A patent/IE37815B1/xx unknown
- 1972-12-29 NL NL7217795A patent/NL7217795A/xx not_active Application Discontinuation
-
1974
- 1974-04-16 ES ES425329A patent/ES425329A1/es not_active Expired
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