IL40895A - Pyrazolo(1,5a)pyrimidines and their preparation - Google Patents

Pyrazolo(1,5a)pyrimidines and their preparation

Info

Publication number
IL40895A
IL40895A IL40895A IL4089572A IL40895A IL 40895 A IL40895 A IL 40895A IL 40895 A IL40895 A IL 40895A IL 4089572 A IL4089572 A IL 4089572A IL 40895 A IL40895 A IL 40895A
Authority
IL
Israel
Prior art keywords
compound
methyl
bromine
alkyl
halogen
Prior art date
Application number
IL40895A
Other languages
English (en)
Other versions
IL40895A0 (en
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US245870A external-priority patent/US3925385A/en
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of IL40895A0 publication Critical patent/IL40895A0/xx
Publication of IL40895A publication Critical patent/IL40895A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL40895A 1971-12-09 1972-11-22 Pyrazolo(1,5a)pyrimidines and their preparation IL40895A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20653871A 1971-12-09 1971-12-09
US245870A US3925385A (en) 1972-04-20 1972-04-20 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US27346572A 1972-07-20 1972-07-20
US29984072A 1972-10-24 1972-10-24

Publications (2)

Publication Number Publication Date
IL40895A0 IL40895A0 (en) 1973-01-30
IL40895A true IL40895A (en) 1976-12-31

Family

ID=27498614

Family Applications (1)

Application Number Title Priority Date Filing Date
IL40895A IL40895A (en) 1971-12-09 1972-11-22 Pyrazolo(1,5a)pyrimidines and their preparation

Country Status (15)

Country Link
JP (1) JPS4864097A (de)
BE (1) BE792533A (de)
BG (1) BG22401A3 (de)
CH (1) CH603652A5 (de)
DD (1) DD104530A5 (de)
DE (1) DE2257547A1 (de)
GB (1) GB1412017A (de)
HU (1) HU168530B (de)
IE (1) IE37189B1 (de)
IL (1) IL40895A (de)
LU (1) LU66597A1 (de)
NL (1) NL7216539A (de)
NO (1) NO137012C (de)
RO (1) RO62762A (de)
SE (1) SE398751B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE3533050A1 (de) * 1985-09-17 1987-03-26 Basf Ag 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide
CA1330079C (en) * 1988-10-13 1994-06-07 Michihiko Tsujitani Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same
DK0591528T3 (da) * 1991-04-22 1999-08-23 Otsuka Pharma Co Ltd Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
ES2164153T3 (es) * 1994-06-21 2002-02-16 Otsuka Pharma Co Ltd Derivado de pirazolo(1,5-a)pirimidina.
WO1997011946A1 (fr) * 1995-09-28 1997-04-03 Otsuka Pharmaceutical Factory, Inc. Analgesiques
FR2771631B1 (fr) * 1997-12-03 2001-02-02 Oreal Compositions de teinture des fibres keratiniques contenant des 3-amino pyrazolo-[1,5-a]-pyrimidines, procede de teinture, nouvelles 3-amino pyrazolo- [1,5-a]-pyrimidines et leur procede de preparation
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
KR101088922B1 (ko) * 2002-09-04 2011-12-01 파마코페이아, 엘엘씨. 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
MX367918B (es) 2013-04-25 2019-09-11 Beigene Ltd Compuestos heterociclicos fusionados como inhibidores de proteina quinasa.
HUE049281T2 (hu) 2013-09-13 2020-09-28 Beigene Switzerland Gmbh Anti-PD1 antitestek, valamint terapeutikumként és diagnosztikumként történõ alkalmazásuk
CN110156892B (zh) 2014-07-03 2023-05-16 百济神州有限公司 抗pd-l1抗体及其作为治疗剂及诊断剂的用途
WO2018007885A1 (en) 2016-07-05 2018-01-11 Beigene, Ltd. COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
CN116478166A (zh) 2016-08-16 2023-07-25 百济神州(苏州)生物科技有限公司 一种化合物的晶型、其制备和用途
WO2018033135A1 (en) 2016-08-19 2018-02-22 Beigene, Ltd. Use of a combination comprising a btk inhibitor for treating cancers
US11555038B2 (en) 2017-01-25 2023-01-17 Beigene, Ltd. Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
KR20200020902A (ko) 2017-06-26 2020-02-26 베이진 엘티디 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료
WO2019034009A1 (en) 2017-08-12 2019-02-21 Beigene, Ltd. BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
CN111801334B (zh) 2017-11-29 2023-06-09 百济神州瑞士有限责任公司 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Also Published As

Publication number Publication date
SE398751B (sv) 1978-01-16
LU66597A1 (de) 1973-03-15
IE37189B1 (en) 1977-05-25
CH603652A5 (de) 1978-08-31
HU168530B (de) 1976-05-28
IL40895A0 (en) 1973-01-30
BG22401A3 (bg) 1977-02-20
DE2257547A1 (de) 1973-06-14
GB1412017A (en) 1975-10-29
DD104530A5 (de) 1974-03-12
BE792533A (fr) 1973-06-08
NO137012C (no) 1977-12-14
NL7216539A (de) 1973-06-13
IE37189L (en) 1973-06-09
RO62762A (fr) 1978-05-15
NO137012B (no) 1977-09-05
JPS4864097A (de) 1973-09-05

Similar Documents

Publication Publication Date Title
IL40895A (en) Pyrazolo(1,5a)pyrimidines and their preparation
CA2422379A1 (en) Pyrazole compounds useful as protein kinase inhibitors
CA2214086C (en) Pyrazole derivatives and processes for the preparation thereof
CA2029265A1 (en) 4- and 6-carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments
MXPA03010529A (es) Derivados de imidazol [1,5a]pirimido[5,4-d]benzazepina, como moduladores del receptor gaba a.
WO2004009597A3 (en) Pyrazolopyrimidines as protein kinase inhibitors
IL160915A0 (en) Indolizines inhibiting kinase proteins
KR20230159419A (ko) Tyk2 억제제 및 이의 용도
CA2628224A1 (en) Vinyl-pyrrolidinone cephalosporins with basic substituents
HRP20010512B1 (en) Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
CN105732637A (zh) 杂芳化合物及其在药物中的应用
KR20230159421A (ko) Tyk2 억제제 및 이의 용도
EP0236673B1 (de) Verfahren zur Herstellung von Chinolin-3-karbonsäure als bakterienfeindliche Wirkstoffe
MX2007003722A (es) Derivados de 6-(piridinil)-4-pirimidona como inhibidores de la tau proteina cinasa 1.
ATE389653T1 (de) 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen
CA2389491A1 (en) Spiro(2h-1-benzopyran-2,4'-piperidine) derivates as glycine transport inhibitors
EP1342716A3 (de) Verfahren zur Herstellung von 4,5-Diamino-1-(2-Hydroxyethyl)-Pyradazol und ihre Säure-Additions-Salze
MY132507A (en) Process for substituted pyridines
MX2007004639A (es) Derivados de imidazo-benzodiazepina.
ES2279361T3 (es) Derivados de (6-(fenoxi)-pirido-3,4-dipirimidin-2-il)-amina como inhibidores de p38 kinasa para el tratamiento de estados inflamatorios tal como artritis reumatoide.
EP0302644A3 (de) Purinverbindungen und ihre Herstellung
IL97913A0 (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
ATE43833T1 (de) Verfahren zur herstellung des 1'ethoxycarbonyloxyethylestersvon benzylpenicillin.
Ochiai et al. Discovery of new orally active phosphodiesterase (PDE4) inhibitors
AU4698199A (en) Pyrazolo(1,5-a)triazine corticotropin releasing factor antagonists