IL39416A - 1,2,4-triazole nucleosides - Google Patents

1,2,4-triazole nucleosides

Info

Publication number
IL39416A
IL39416A IL39416A IL3941672A IL39416A IL 39416 A IL39416 A IL 39416A IL 39416 A IL39416 A IL 39416A IL 3941672 A IL3941672 A IL 3941672A IL 39416 A IL39416 A IL 39416A
Authority
IL
Israel
Prior art keywords
triazole nucleosides
nucleosides
triazole
Prior art date
Application number
IL39416A
Other languages
English (en)
Other versions
IL39416A0 (en
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of IL39416A0 publication Critical patent/IL39416A0/xx
Publication of IL39416A publication Critical patent/IL39416A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL39416A 1971-06-01 1972-05-11 1,2,4-triazole nucleosides IL39416A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14901771A 1971-06-01 1971-06-01
US24025272A 1972-03-31 1972-03-31

Publications (2)

Publication Number Publication Date
IL39416A0 IL39416A0 (en) 1972-07-26
IL39416A true IL39416A (en) 1975-07-28

Family

ID=26846393

Family Applications (1)

Application Number Title Priority Date Filing Date
IL39416A IL39416A (en) 1971-06-01 1972-05-11 1,2,4-triazole nucleosides

Country Status (28)

Country Link
US (1) US3798209A (ro)
JP (5) JPS5527076B1 (ro)
AR (1) AR199463A1 (ro)
AU (1) AU461900B2 (ro)
BE (1) BE784195A (ro)
BG (1) BG22827A3 (ro)
CA (1) CA997756A (ro)
CH (1) CH614452A5 (ro)
DD (1) DD99791A5 (ro)
DE (1) DE2220246A1 (ro)
DK (2) DK143069C (ro)
EG (1) EG11406A (ro)
ES (1) ES403142A1 (ro)
FR (1) FR2140126B1 (ro)
GB (1) GB1353565A (ro)
HK (1) HK23876A (ro)
HU (1) HU167614B (ro)
IE (1) IE36478B1 (ro)
IL (1) IL39416A (ro)
IN (1) IN142290B (ro)
IS (1) IS913B6 (ro)
LU (1) LU65446A1 (ro)
MC (1) MC921A1 (ro)
MY (1) MY7600203A (ro)
NL (1) NL7207156A (ro)
NO (1) NO138805C (ro)
RO (1) RO62435A (ro)
SE (3) SE405604B (ro)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984396A (en) * 1971-06-01 1976-10-05 Icn Pharmaceuticals, Inc. 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters
DE2401449A1 (de) * 1973-01-16 1974-07-25 Voorhees Pharmazeutische zusammensetzung zur linderung von hautproliferationserkrankungen
US3888843A (en) * 1973-06-12 1975-06-10 Toyo Jozo Kk 4-carbamoyl-1-' -d-ribofuranosylimidazolium-5-olate
AR207138A1 (es) * 1974-03-18 1976-09-15 Icn Pharmaceuticals Metodo para la obtencion de 1,2,4-triazoles n-substituidos y sus sales de adicion
GB1482736A (en) * 1974-03-18 1977-08-10 Icn Pharmaceuticals 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives
US3960836A (en) * 1974-07-22 1976-06-01 Eli Lilly And Company Acylated derivatives of pyrazofurin and process for their preparation
US4007198A (en) * 1975-05-01 1977-02-08 American Cyanamid Company Substituted 1,2,4-triazole carboxamide
US4138547A (en) * 1977-12-22 1979-02-06 Icn Pharmaceuticals, Inc. Process for preparing 1,2,4-triazole nucleosides
JPS57146593A (en) * 1981-03-09 1982-09-10 Ajinomoto Co Inc Preparation of ribofuranosyltriazole derivative
US4451648A (en) * 1981-08-19 1984-05-29 The United States Of America As Represented By The Department Of Health And Human Services Process for the production of 2-β-D-ribofuranosylthiazole-4-carboxamide
US4531001A (en) * 1982-03-23 1985-07-23 Brigham Young University 2-β-D-ribofuranosylselenazole-4-carboxamide compounds
US4446315A (en) * 1982-09-24 1984-05-01 The United States Of America As Represented By The Department Of Health And Human Services Adenosine 5'-triphosphate-4-carboxamide-ribofuranosylthiazole
JPS5964648U (ja) * 1982-10-22 1984-04-28 阿波野 政晴 日覆用骨格
BE902199A (fr) * 1984-10-29 1985-07-31 Vira Tek Inc Procede de traitement medical de maladies virales utilisant le 1-beta-d-ribofurannosyl-1, 2,4-triazole-3-carboxamide.
NZ213370A (en) * 1985-01-16 1989-03-29 Vira Tek Inc Method of treating viral infections of selected trees and field crops using ribavirin (1-b-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) or the 2,3,5-triacetyl or 5'-butyryl derivative thereof
DE3606634A1 (de) * 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO1987005807A1 (en) * 1986-03-27 1987-10-08 Harry Edward Gruber A method of increasing adenosine excretion
US4925930A (en) * 1988-11-02 1990-05-15 Nucleic Acid Research Institute Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
IL148514A0 (en) * 1999-12-23 2002-09-12 Icn Pharmaceuticals Compositions and methods for l-nucleosides, l-nucleotides, and their analogs
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US7638496B2 (en) * 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
PY0111577A (es) * 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
CZ301182B6 (cs) * 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
US6815542B2 (en) * 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
CN1460109A (zh) * 2000-08-22 2003-12-03 里巴药品公司 改善疾病治疗的特异性
US6878364B2 (en) * 2000-12-01 2005-04-12 Cornell Research Foundation, Inc. Animal model for flaviviridae infection
US20040014696A1 (en) * 2000-12-07 2004-01-22 Johnson Lau Specificity in treatment of diseases
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
DE60101056T2 (de) * 2001-07-30 2004-05-19 Clariant Life Science Molecules (Italia) S.P.A., Origgio Verfahren zur Herstellung von Ribavirin
WO2003026589A2 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
RU2004116821A (ru) * 2001-11-02 2005-04-20 Сандоз Инк. (Us) Способ получения быстрорастворимой композиции с высоким содержанием рибавирина
KR100411398B1 (ko) 2001-12-06 2003-12-18 주식회사유한양행 베타-디-리보푸라노즈 유도체의 제조방법
TW200500375A (en) 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
JP2005533824A (ja) * 2002-06-28 2005-11-10 イデニクス(ケイマン)リミテツド フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
CN1849142A (zh) * 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′-支链核苷和黄病毒突变
JP5116972B2 (ja) * 2002-12-12 2013-01-09 イデニクス(ケイマン)リミテツド 2’−分枝ヌクレオシドの製造方法
KR20050110611A (ko) * 2002-12-23 2005-11-23 이데닉스 (케이만) 리미티드 3'-뉴클레오사이드 프로드럭의 생산 방법
US20050049204A1 (en) * 2003-03-28 2005-03-03 Otto Michael J. Compounds for the treatment of flaviviridae infections
RU2358979C2 (ru) * 2003-05-30 2009-06-20 Фармассет, Инк. Модифицированные фторированные аналоги нуклеозида
BRPI0412849A (pt) * 2003-07-25 2006-09-26 Idenix Cayman Ltd compostos, composições e usos de análogos de nucleosìdeo de purina para o tratamento de flaviviridae, incluindo hepatite c
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
US20060040944A1 (en) * 2004-06-23 2006-02-23 Gilles Gosselin 5-Aza-7-deazapurine derivatives for treating Flaviviridae
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2769377T3 (es) * 2004-09-14 2020-06-25 Gilead Pharmasset Llc Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo
CN101263156A (zh) 2005-07-25 2008-09-10 因特蒙公司 C型肝炎病毒复制的新颖大环抑制剂
JP2009511595A (ja) * 2005-10-11 2009-03-19 インターミューン・インコーポレーテッド C型肝炎ウイルスの複製を阻害する化合物および方法
US7781576B2 (en) * 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
UA100666C2 (uk) 2006-04-11 2013-01-25 Новартіс Аг Інгібітори нсv/віл та їх застосування
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20110117054A1 (en) 2007-08-27 2011-05-19 National University Corporation Nagoya University Use of ribavirin in blood coagulation disorder
JPWO2009028575A1 (ja) 2007-08-27 2010-12-02 国立大学法人名古屋大学 血液凝固第vii因子プロモーターの活性化剤及びその利用
US20090082414A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched viramidine
WO2009105258A1 (en) 2008-02-22 2009-08-27 Nektar Therapeutics Al, Corporation Oligomer conjugates of heteropentacyclic nucleosides
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
AP2010005416A0 (en) * 2008-04-15 2010-10-31 Intermune Inc Novel macrocyclic inhibitors of hepatitis c virus replication.
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA201170441A1 (ru) * 2008-10-15 2012-05-30 Интермьюн, Инк. Терапевтические противовирусные пептиды
SI2364314T1 (sl) 2008-12-09 2014-07-31 Gilead Sciences, Inc. Modulatorji Tollu podobnih receptorjev
CA2748034A1 (en) * 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
MX2011006891A (es) * 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
KR20130026410A (en) * 2009-09-28 2013-03-13 Intermune Inc Cyclic peptide inhibitors of hepatitis c virus replication
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
WO2011076923A1 (en) 2009-12-23 2011-06-30 Institut National De La Sante Et De La Recherche Medicale Inhibitor for inosine monophosphate (imp) dehydrogenase and/or viral rna polymerase for treatment of hepatitis e
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
CN102843909A (zh) * 2010-01-25 2012-12-26 埃南塔制药公司 丙型肝炎病毒抑制剂
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
BR112013008510A2 (pt) 2010-10-08 2016-07-05 Novartis Ag vitamina e formulações de inibidores de sulfamida ns3
EP3042910B1 (en) 2010-11-30 2019-01-09 Gilead Pharmasset LLC 2'-spiro-nucleosides for use in the therapy of hepatitis c
CA2822037A1 (en) 2010-12-20 2012-06-28 Gilead Sciences, Inc. Methods for treating hcv
CA2752008A1 (en) 2011-09-13 2013-03-13 Universite De Montreal Combination therapy using ribavirin as elf4e inhibitor
EP2709613B2 (en) 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
US20140205566A1 (en) 2012-11-30 2014-07-24 Novartis Ag Cyclic nucleuoside derivatives and uses thereof
LT2950786T (lt) 2013-01-31 2020-03-10 Gilead Pharmasset Llc Dviejų antivirusinių junginių preparatų kompozicija
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych
EA201692507A1 (ru) 2014-06-23 2017-04-28 Сановель Илач Санайи Ве Тиджарет А.Ш. Фармацевтические комбинации софосбувира и рибавирина
EA201692514A1 (ru) 2014-06-23 2017-04-28 Сановель Илач Санайи Ве Тиджарет А.Ш. Фармацевтические композиции на основе софосбувира и рибавирина с модифицированным высвобождением
EA201692515A1 (ru) 2014-06-23 2017-05-31 Сановель Илач Санайи Ве Тиджарет А.Ш. Новая фармацевтическая композиция на основе софосбувира и рибавирина
PT3166607T (pt) 2014-07-11 2022-12-07 Gilead Sciences Inc Moduladores de receptores de tipo toll para o tratamento do vih
SG11201701520TA (en) 2014-09-16 2017-04-27 Gilead Sciences Inc Solid forms of a toll-like receptor modulator
TW201817714A (zh) 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 抑制3c及3cl蛋白酶之化合物及其使用方法
CN110713464B (zh) * 2019-10-31 2023-03-31 重庆大学 一种芳基1,2,4-三氮唑核苷化合物及其制备方法和应用
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN116621899B (zh) * 2023-05-18 2026-02-06 中国人民解放军军事科学院军事医学研究院 非天然核苷类似物及其用途

Also Published As

Publication number Publication date
BE784195A (fr) 1972-11-30
LU65446A1 (ro) 1972-10-05
AU4215772A (en) 1973-12-20
IS913B6 (is) 1975-09-15
EG11406A (en) 1981-06-30
IE36478L (en) 1972-12-01
DK143069B (da) 1981-03-23
DK509876A (da) 1976-11-12
JPS53108973A (en) 1978-09-22
IL39416A0 (en) 1972-07-26
MC921A1 (fr) 1973-01-25
NO138805B (no) 1978-08-07
SE7801925L (sv) 1978-02-20
IS2075A7 (is) 1973-01-02
BG22827A3 (bg) 1977-04-20
JPS5519239B2 (ro) 1980-05-24
HU167614B (ro) 1975-11-28
AU461900B2 (en) 1975-06-12
CH614452A5 (en) 1979-11-30
AR199463A1 (es) 1974-09-09
JPS5387356A (en) 1978-08-01
DD99791A5 (ro) 1973-08-20
ES403142A1 (es) 1975-05-01
JPS53124271A (en) 1978-10-30
GB1353565A (en) 1974-05-22
MY7600203A (en) 1976-12-31
SE7801926L (sv) 1978-02-20
CA997756A (en) 1976-09-28
HK23876A (en) 1976-04-30
SE405604B (sv) 1978-12-18
NL7207156A (ro) 1972-12-05
JPS5519238B2 (ro) 1980-05-24
JPS5395974A (en) 1978-08-22
JPS5527076B1 (ro) 1980-07-17
IE36478B1 (en) 1976-11-10
US3798209A (en) 1974-03-19
FR2140126A1 (ro) 1973-01-12
IN142290B (ro) 1977-06-18
DK143069C (da) 1981-11-02
DE2220246A1 (de) 1972-12-14
NO138805C (no) 1978-11-15
FR2140126B1 (ro) 1976-04-16
RO62435A (fr) 1978-03-15

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