IL314712A - Immunogenic compositions for treatment of hepatitis b - Google Patents

Immunogenic compositions for treatment of hepatitis b

Info

Publication number
IL314712A
IL314712A IL314712A IL31471224A IL314712A IL 314712 A IL314712 A IL 314712A IL 314712 A IL314712 A IL 314712A IL 31471224 A IL31471224 A IL 31471224A IL 314712 A IL314712 A IL 314712A
Authority
IL
Israel
Prior art keywords
hbsag
aluminum
antigen
hepatitis
adjuvant
Prior art date
Application number
IL314712A
Other languages
English (en)
Hebrew (he)
Inventor
David Evander Anderson
Tanvir Ahmed
Original Assignee
Variation Biotechnologies Inc
David Evander Anderson
Tanvir Ahmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Variation Biotechnologies Inc, David Evander Anderson, Tanvir Ahmed filed Critical Variation Biotechnologies Inc
Publication of IL314712A publication Critical patent/IL314712A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL314712A 2018-11-13 2019-11-13 Immunogenic compositions for treatment of hepatitis b IL314712A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862760439P 2018-11-13 2018-11-13
PCT/IB2019/001230 WO2020099927A1 (en) 2018-11-13 2019-11-13 Immunogenic compositions for treatment of hepatitis b

Publications (1)

Publication Number Publication Date
IL314712A true IL314712A (en) 2024-10-01

Family

ID=70731781

Family Applications (2)

Application Number Title Priority Date Filing Date
IL314712A IL314712A (en) 2018-11-13 2019-11-13 Immunogenic compositions for treatment of hepatitis b
IL283039A IL283039B2 (en) 2018-11-13 2019-11-13 Immunological preparations for the treatment of hepatitis B

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL283039A IL283039B2 (en) 2018-11-13 2019-11-13 Immunological preparations for the treatment of hepatitis B

Country Status (10)

Country Link
US (2) US12128100B2 (https=)
EP (1) EP3880244A4 (https=)
JP (2) JP2022513001A (https=)
KR (1) KR102943479B1 (https=)
CN (2) CN118987191A (https=)
BR (1) BR112021009234A2 (https=)
IL (2) IL314712A (https=)
MX (1) MX2021005588A (https=)
WO (1) WO2020099927A1 (https=)
ZA (1) ZA202103976B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020099927A1 (en) 2018-11-13 2020-05-22 Variation Biotechnologies Inc. Immunogenic compositions for treatment of hepatitis b
US20240123060A1 (en) * 2019-06-21 2024-04-18 Variation Biotechnologies Inc. Improved therapeutic composition comprising hepatitis b antigen having s, pre-s1 and pre-s2 protein, aluminium phosphate and interferon-alpha and use thereof for treatment of hepatitis b
AU2024313135A1 (en) 2023-06-23 2026-01-22 Brii Biosciences, Inc. Assessment and treatment of chronic hepatitis b

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242812A (en) 1989-02-07 1993-09-07 Bio-Technology General Corp. Method for production and purification of hepatitis B vaccine
MA22842A1 (fr) 1992-03-27 1993-10-01 Smithkline Beecham Biolog Procede de preparation de compositions de vaccin.
GB9503863D0 (en) 1995-02-25 1995-04-19 Smithkline Beecham Biolog Vaccine compositions
GB9809507D0 (en) * 1998-05-01 1998-07-01 Smithkline Beecham Biolog Novel composition
CN1305527C (zh) 2003-11-21 2007-03-21 薛平 乙型肝炎治疗疫苗及其制备方法
KR100836745B1 (ko) 2007-01-31 2008-06-10 (주)두비엘 Ｈｂｖ 백신 및 그의 제조 방법
CN102949717A (zh) 2012-07-06 2013-03-06 中国疾病预防控制中心病毒病预防控制所 一种含poly I:C佐剂的新型乙肝疫苗制剂
CN104043120B (zh) 2013-03-13 2017-05-31 南京赛威信生物医药有限公司 乙型肝炎疫苗
WO2018166298A1 (en) 2017-03-13 2018-09-20 Fudan University Immunopotentiator, immunotherapeutic pharmaceutical composition and its preparation and use
WO2020099927A1 (en) * 2018-11-13 2020-05-22 Variation Biotechnologies Inc. Immunogenic compositions for treatment of hepatitis b
US20240123060A1 (en) 2019-06-21 2024-04-18 Variation Biotechnologies Inc. Improved therapeutic composition comprising hepatitis b antigen having s, pre-s1 and pre-s2 protein, aluminium phosphate and interferon-alpha and use thereof for treatment of hepatitis b

Also Published As

Publication number Publication date
US20250269013A1 (en) 2025-08-28
EP3880244A1 (en) 2021-09-22
KR102943479B1 (ko) 2026-03-27
ZA202103976B (en) 2023-09-27
CA3119581A1 (en) 2020-05-22
KR20210151047A (ko) 2021-12-13
BR112021009234A2 (pt) 2021-09-08
US12128100B2 (en) 2024-10-29
IL283039B1 (en) 2024-09-01
JP2024174990A (ja) 2024-12-17
CN113423423A (zh) 2021-09-21
MX2021005588A (es) 2021-08-11
IL283039A (en) 2021-06-30
WO2020099927A1 (en) 2020-05-22
EP3880244A4 (en) 2022-08-17
US20230079703A1 (en) 2023-03-16
IL283039B2 (en) 2025-01-01
JP2022513001A (ja) 2022-02-07
CN113423423B (zh) 2024-08-13
CN118987191A (zh) 2024-11-22

Similar Documents

Publication Publication Date Title
JP5814507B2 (ja) ワクチン
RU2160120C2 (ru) Комбинированная вакцина на основе поверхностного антигена вируса гепатита в, способ ее получения и способ предупреждения инфекции гепатита в у человека
US20250269013A1 (en) Immunogenic compositions for treatment of hepatitis b
JP6499592B2 (ja) Ｂ型肝炎ワクチン
JPH07505372A (ja) ３−ｏ−脱アシル化モノホスホリル脂質ａ含有の肝炎ワクチン
TWI755383B (zh) 包括b型肝炎病毒之表面及核殼體抗原的藥學組成物
CN112996538B (zh) 免疫原性组合物
JP2022516041A (ja) Ｂ型肝炎を治療するための薬物製剤、その製造方法及び用途
CA3119581C (en) Immunogenic compositions for treatment of hepatitis b
EP3986459A1 (en) Improved therapeutic composition comprising hepatitis b antigen having s, pre-s1 and pre-s2 protein, aluminium phosphate and interferon-alpha and use thereof for treatment of hepatitis b
CN102813920A (zh) 一种疫苗佐剂
HK40050381A (en) Immunogenic compositions for treatment of hepatitis b
CN103566369B (zh) 一种在慢性乙肝病毒感染状态下诱导机体产生特异性免疫的乙肝疫苗
HK40050381B (zh) 用於治疗乙型肝炎的免疫原性组合物
WO2020051566A1 (en) Vaccines with enhanced immune response and methods for their preparation
KR20220107161A (ko) B형 간염 바이러스 복제 및 b형 간염 바이러스 표면 항원 분비의 억제를 위한 생분해성 나노복합체 백신, 방법
EA040981B1 (ru) Фармацевтическая композиция, которая включает поверхностные и нуклеокапсидные антигены вируса гепатита b
EA045827B1 (ru) Иммуногенные композиции
HK1259329B (en) Pharmaceutical composition that includes the surface and nucleocapsid antigens of the hepatitis b virus