CN118987191A - 用于治疗乙型肝炎的免疫原性组合物 - Google Patents
用于治疗乙型肝炎的免疫原性组合物 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862760439P | 2018-11-13 | 2018-11-13 | |
| US62/760,439 | 2018-11-13 | ||
| PCT/IB2019/001230 WO2020099927A1 (en) | 2018-11-13 | 2019-11-13 | Immunogenic compositions for treatment of hepatitis b |
| CN201980074891.6A CN113423423B (zh) | 2018-11-13 | 2019-11-13 | 用于治疗乙型肝炎的免疫原性组合物 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201980074891.6A Division CN113423423B (zh) | 2018-11-13 | 2019-11-13 | 用于治疗乙型肝炎的免疫原性组合物 |
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| Publication Number | Publication Date |
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| CN118987191A true CN118987191A (zh) | 2024-11-22 |
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| CN202410981157.0A Pending CN118987191A (zh) | 2018-11-13 | 2019-11-13 | 用于治疗乙型肝炎的免疫原性组合物 |
| CN201980074891.6A Active CN113423423B (zh) | 2018-11-13 | 2019-11-13 | 用于治疗乙型肝炎的免疫原性组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201980074891.6A Active CN113423423B (zh) | 2018-11-13 | 2019-11-13 | 用于治疗乙型肝炎的免疫原性组合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12128100B2 (https=) |
| EP (1) | EP3880244A4 (https=) |
| JP (2) | JP2022513001A (https=) |
| KR (1) | KR102943479B1 (https=) |
| CN (2) | CN118987191A (https=) |
| BR (1) | BR112021009234A2 (https=) |
| IL (2) | IL314712A (https=) |
| MX (1) | MX2021005588A (https=) |
| WO (1) | WO2020099927A1 (https=) |
| ZA (1) | ZA202103976B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020099927A1 (en) | 2018-11-13 | 2020-05-22 | Variation Biotechnologies Inc. | Immunogenic compositions for treatment of hepatitis b |
| US20240123060A1 (en) * | 2019-06-21 | 2024-04-18 | Variation Biotechnologies Inc. | Improved therapeutic composition comprising hepatitis b antigen having s, pre-s1 and pre-s2 protein, aluminium phosphate and interferon-alpha and use thereof for treatment of hepatitis b |
| AU2024313135A1 (en) | 2023-06-23 | 2026-01-22 | Brii Biosciences, Inc. | Assessment and treatment of chronic hepatitis b |
Family Cites Families (11)
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| US5242812A (en) | 1989-02-07 | 1993-09-07 | Bio-Technology General Corp. | Method for production and purification of hepatitis B vaccine |
| MA22842A1 (fr) | 1992-03-27 | 1993-10-01 | Smithkline Beecham Biolog | Procede de preparation de compositions de vaccin. |
| GB9503863D0 (en) | 1995-02-25 | 1995-04-19 | Smithkline Beecham Biolog | Vaccine compositions |
| GB9809507D0 (en) * | 1998-05-01 | 1998-07-01 | Smithkline Beecham Biolog | Novel composition |
| CN1305527C (zh) | 2003-11-21 | 2007-03-21 | 薛平 | 乙型肝炎治疗疫苗及其制备方法 |
| KR100836745B1 (ko) | 2007-01-31 | 2008-06-10 | (주)두비엘 | Ｈｂｖ 백신 및 그의 제조 방법 |
| CN102949717A (zh) | 2012-07-06 | 2013-03-06 | 中国疾病预防控制中心病毒病预防控制所 | 一种含poly I:C佐剂的新型乙肝疫苗制剂 |
| CN104043120B (zh) | 2013-03-13 | 2017-05-31 | 南京赛威信生物医药有限公司 | 乙型肝炎疫苗 |
| WO2018166298A1 (en) | 2017-03-13 | 2018-09-20 | Fudan University | Immunopotentiator, immunotherapeutic pharmaceutical composition and its preparation and use |
| WO2020099927A1 (en) * | 2018-11-13 | 2020-05-22 | Variation Biotechnologies Inc. | Immunogenic compositions for treatment of hepatitis b |
| US20240123060A1 (en) | 2019-06-21 | 2024-04-18 | Variation Biotechnologies Inc. | Improved therapeutic composition comprising hepatitis b antigen having s, pre-s1 and pre-s2 protein, aluminium phosphate and interferon-alpha and use thereof for treatment of hepatitis b |
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2019
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- 2019-11-13 BR BR112021009234-0A patent/BR112021009234A2/pt unknown
- 2019-11-13 IL IL314712A patent/IL314712A/en unknown
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- 2019-11-13 KR KR1020217018153A patent/KR102943479B1/ko active Active
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- 2019-11-13 IL IL283039A patent/IL283039B2/en unknown
- 2019-11-13 JP JP2021525603A patent/JP2022513001A/ja active Pending
- 2019-11-13 CN CN201980074891.6A patent/CN113423423B/zh active Active
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2021
- 2021-06-09 ZA ZA2021/03976A patent/ZA202103976B/en unknown
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2024
- 2024-09-11 JP JP2024157339A patent/JP2024174990A/ja active Pending
- 2024-09-12 US US18/883,612 patent/US20250269013A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20250269013A1 (en) | 2025-08-28 |
| EP3880244A1 (en) | 2021-09-22 |
| KR102943479B1 (ko) | 2026-03-27 |
| ZA202103976B (en) | 2023-09-27 |
| CA3119581A1 (en) | 2020-05-22 |
| KR20210151047A (ko) | 2021-12-13 |
| BR112021009234A2 (pt) | 2021-09-08 |
| US12128100B2 (en) | 2024-10-29 |
| IL283039B1 (en) | 2024-09-01 |
| JP2024174990A (ja) | 2024-12-17 |
| CN113423423A (zh) | 2021-09-21 |
| MX2021005588A (es) | 2021-08-11 |
| IL283039A (en) | 2021-06-30 |
| WO2020099927A1 (en) | 2020-05-22 |
| EP3880244A4 (en) | 2022-08-17 |
| US20230079703A1 (en) | 2023-03-16 |
| IL283039B2 (en) | 2025-01-01 |
| IL314712A (en) | 2024-10-01 |
| JP2022513001A (ja) | 2022-02-07 |
| CN113423423B (zh) | 2024-08-13 |
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