IL305668A - Antisense oligonucleotides to inhibit alpha-synuclein expression - Google Patents
Antisense oligonucleotides to inhibit alpha-synuclein expressionInfo
- Publication number
- IL305668A IL305668A IL305668A IL30566823A IL305668A IL 305668 A IL305668 A IL 305668A IL 305668 A IL305668 A IL 305668A IL 30566823 A IL30566823 A IL 30566823A IL 305668 A IL305668 A IL 305668A
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- Israel
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/35—Nature of the modification
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Applications Claiming Priority (3)
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| EP21315033 | 2021-03-08 | ||
| EP21306123 | 2021-08-17 | ||
| PCT/EP2022/055770 WO2022189363A1 (en) | 2021-03-08 | 2022-03-07 | Antisense oligonucleotides for inhibiting alpha-synuclein expression |
Publications (1)
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| IL305668A true IL305668A (en) | 2023-11-01 |
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| IL305668A IL305668A (en) | 2021-03-08 | 2022-03-07 | Antisense oligonucleotides to inhibit alpha-synuclein expression |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1993007883A1 (en) | 1991-10-24 | 1993-04-29 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| WO2011097643A1 (en) * | 2010-02-08 | 2011-08-11 | Isis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
| CA2817960C (en) | 2010-11-17 | 2020-06-09 | Isis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| EP3467109A1 (en) * | 2011-02-08 | 2019-04-10 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| DK2751270T3 (en) | 2011-08-29 | 2018-10-29 | Ionis Pharmaceuticals Inc | OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE |
| EP2839006B1 (en) * | 2012-04-20 | 2018-01-03 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| CN104884618A (zh) | 2012-11-15 | 2015-09-02 | 罗氏创新中心哥本哈根有限公司 | 寡核苷酸缀合物 |
| PT2992098T (pt) | 2013-05-01 | 2019-07-05 | Ionis Pharmaceuticals Inc | Composições e métodos para modular a expressão de hbv e ttr |
| LT3013959T (lt) | 2013-06-27 | 2020-03-10 | Roche Innovation Center Copenhagen A/S | Priešprasmiai oligomerai ir konjugatai, nukreirti į pcsk9 |
| MA43072A (fr) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| WO2018154418A1 (en) * | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| TWI809004B (zh) * | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| CA3085964A1 (en) * | 2018-01-12 | 2019-07-18 | Roche Innovation Center Copenhagen A/S | Alpha-synuclein antisense oligonucleotides and uses thereof |
| CN114072501A (zh) | 2019-05-06 | 2022-02-18 | 马萨诸塞大学 | 抗c9orf72寡核苷酸及相关方法 |
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- 2022-03-07 MX MX2023010535A patent/MX2023010535A/es unknown
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| EP4305168A1 (en) | 2024-01-17 |
| WO2022189363A1 (en) | 2022-09-15 |
| AU2022234522A1 (en) | 2023-10-26 |
| JP2024508956A (ja) | 2024-02-28 |
| CL2023002644A1 (es) | 2024-04-01 |
| PE20240696A1 (es) | 2024-04-10 |
| CA3212650A1 (en) | 2022-09-15 |
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