IL305668A - אוליגונוקליאוטידים אנטיסנס לעיכוב ביטוי אלפא-סינוקלאין - Google Patents
אוליגונוקליאוטידים אנטיסנס לעיכוב ביטוי אלפא-סינוקלאיןInfo
- Publication number
- IL305668A IL305668A IL305668A IL30566823A IL305668A IL 305668 A IL305668 A IL 305668A IL 305668 A IL305668 A IL 305668A IL 30566823 A IL30566823 A IL 30566823A IL 305668 A IL305668 A IL 305668A
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (3)
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| EP21315033 | 2021-03-08 | ||
| EP21306123 | 2021-08-17 | ||
| PCT/EP2022/055770 WO2022189363A1 (en) | 2021-03-08 | 2022-03-07 | Antisense oligonucleotides for inhibiting alpha-synuclein expression |
Publications (1)
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| IL305668A true IL305668A (he) | 2023-11-01 |
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| PE (1) | PE20240696A1 (he) |
| TW (1) | TW202305132A (he) |
| WO (1) | WO2022189363A1 (he) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2916292A (en) | 1991-10-24 | 1993-05-21 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| EP3561060A1 (en) * | 2010-02-08 | 2019-10-30 | Ionis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
| EP3521451A1 (en) | 2010-11-17 | 2019-08-07 | Ionis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| WO2012109395A1 (en) * | 2011-02-08 | 2012-08-16 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| DK2751270T3 (en) | 2011-08-29 | 2018-10-29 | Ionis Pharmaceuticals Inc | OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE |
| US9914922B2 (en) * | 2012-04-20 | 2018-03-13 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| US20150291958A1 (en) | 2012-11-15 | 2015-10-15 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
| PL2992098T3 (pl) | 2013-05-01 | 2019-09-30 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji hbv i ttr |
| EP3591054A1 (en) | 2013-06-27 | 2020-01-08 | Roche Innovation Center Copenhagen A/S | Antisense oligomers and conjugates targeting pcsk9 |
| MA43072A (fr) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| US20200040061A1 (en) * | 2017-02-22 | 2020-02-06 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| TWI809004B (zh) * | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| BR112020012921A2 (pt) * | 2018-01-12 | 2020-12-08 | Roche Innovation Center Copenhagen A/S | Oligonucleotídeos antissenso de alfa-sinucleína e usos dos mesmos |
| CN114072501A (zh) | 2019-05-06 | 2022-02-18 | 马萨诸塞大学 | 抗c9orf72寡核苷酸及相关方法 |
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| PE20240696A1 (es) | 2024-04-10 |
| MX2023010535A (es) | 2023-09-19 |
| TW202305132A (zh) | 2023-02-01 |
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| CA3212650A1 (en) | 2022-09-15 |
| JP2024508956A (ja) | 2024-02-28 |
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| CL2023002644A1 (es) | 2024-04-01 |
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