IL303257A - Selective p2x3 modulators - Google Patents
Selective p2x3 modulatorsInfo
- Publication number
- IL303257A IL303257A IL303257A IL30325723A IL303257A IL 303257 A IL303257 A IL 303257A IL 303257 A IL303257 A IL 303257A IL 30325723 A IL30325723 A IL 30325723A IL 303257 A IL303257 A IL 303257A
- Authority
- IL
- Israel
- Prior art keywords
- selective
- antagonist
- receptor antagonism
- patient
- compound
- Prior art date
Links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Amplifiers (AREA)
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| KR20210074315A (ko) * | 2018-10-10 | 2021-06-21 | 벨루스 헬스 코프 인크. | P2x3 길항제를 사용한 소양증의 치료 |
| LT3880678T (lt) | 2018-11-13 | 2025-06-25 | Glaxosmithkline Intellectual Property (No.3) Limited | P2x3 moduliatoriaus metilo (s)-2-((2-(2,6-difluor-4-(metilkarbamoil)fenil) -7-metilimidazo[1,2-a]piridin-3-il)metil)morfolin-4-karboksilato kristalinės formos |
| SG11202106706TA (en) * | 2018-12-29 | 2021-07-29 | Wuhan Ll Science And Technology Development Co Ltd | Heterocyclic compound intermediate, preparation method therefor and application thereof |
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| CN112409331B (zh) * | 2019-08-21 | 2024-02-20 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
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| BR112022021789A2 (pt) | 2020-04-27 | 2023-03-07 | Twist Bioscience Corp | Bibliotecas de ácido nucléico variantes para coronavírus |
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| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
| CA3184482A1 (en) * | 2020-06-29 | 2022-01-06 | Liang Wang | Crystalline form of heterocyclic compound, preparation method therefor and application thereof |
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| CN102741245B (zh) * | 2009-11-18 | 2014-11-05 | 尼奥梅德研究院 | 苯并咪唑化合物及其用途 |
| US20130053338A1 (en) * | 2010-03-19 | 2013-02-28 | Per-Olof Berggren | Use of P2X Purinergic Receptor Agonists to Enhance Insulin Secretion in Pancreatic Beta Cells |
| EP2951177B1 (en) * | 2013-01-31 | 2018-04-04 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| NZ716977A (en) * | 2013-08-23 | 2017-09-29 | Afferent Pharmaceuticals Inc | Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of acute and sub-acute cough, urge to cough and chronic cough, in respiratory diseases |
| SI3587417T1 (sl) * | 2014-12-09 | 2022-04-29 | Bayer Ag | 1,3-tiazol-2-il substituirani benzamidi |
| EP3355889B1 (en) * | 2015-09-29 | 2023-02-15 | Afferent Pharmaceuticals Inc. | Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| EP3528813B1 (en) * | 2016-09-30 | 2025-04-16 | ABS Development 1, Inc. | P2x3 and/or p2x2/3 compounds and methods |
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2018
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- 2018-09-14 JP JP2020537064A patent/JP7242681B2/ja active Active
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- 2018-09-14 KR KR1020207010982A patent/KR102713354B1/ko active Active
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- 2018-09-14 IL IL303257A patent/IL303257A/en unknown
- 2018-09-14 WO PCT/IB2018/001513 patent/WO2019064079A2/en not_active Ceased
- 2018-09-14 IL IL273348A patent/IL273348B2/en unknown
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- 2018-09-14 EP EP18860273.4A patent/EP3684368B8/en active Active
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2020
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2021
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2022
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| EP4331669A3 (en) | 2024-05-01 |
| MX2020002968A (es) | 2020-08-17 |
| US10111883B1 (en) | 2018-10-30 |
| AU2018342751A1 (en) | 2020-04-23 |
| CN111601601A (zh) | 2020-08-28 |
| US20210069201A1 (en) | 2021-03-11 |
| WO2019064079A3 (en) | 2019-05-16 |
| US20230248736A1 (en) | 2023-08-10 |
| SG11202002460QA (en) | 2020-04-29 |
| EP4331669A2 (en) | 2024-03-06 |
| CA3076150C (en) | 2024-01-02 |
| JP2020534355A (ja) | 2020-11-26 |
| EP3684368B1 (en) | 2024-01-03 |
| KR20200092938A (ko) | 2020-08-04 |
| US20200230148A1 (en) | 2020-07-23 |
| EP3684368A2 (en) | 2020-07-29 |
| US20220160724A1 (en) | 2022-05-26 |
| AU2018342751B2 (en) | 2023-06-15 |
| JP7242681B2 (ja) | 2023-03-20 |
| CA3076150A1 (en) | 2019-04-04 |
| IL273348B1 (en) | 2023-07-01 |
| IL273348A (en) | 2020-05-31 |
| US20210322432A1 (en) | 2021-10-21 |
| EP3684368A4 (en) | 2021-05-26 |
| WO2019064079A2 (en) | 2019-04-04 |
| EP3684368B8 (en) | 2024-02-14 |
| IL273348B2 (en) | 2023-11-01 |
| KR102713354B1 (ko) | 2024-10-02 |
| ES2969868T3 (es) | 2024-05-23 |
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