IL273389B2 - Novel anti-cd19 antibodies - Google Patents

Novel anti-cd19 antibodies

Info

Publication number
IL273389B2
IL273389B2 IL273389A IL27338920A IL273389B2 IL 273389 B2 IL273389 B2 IL 273389B2 IL 273389 A IL273389 A IL 273389A IL 27338920 A IL27338920 A IL 27338920A IL 273389 B2 IL273389 B2 IL 273389B2
Authority
IL
Israel
Prior art keywords
seq
heavy chain
light chain
variable region
cdr sequences
Prior art date
Application number
IL273389A
Other languages
English (en)
Hebrew (he)
Other versions
IL273389B1 (en
IL273389A (en
Original Assignee
Wuxi Biologics Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi Biologics Ireland Ltd filed Critical Wuxi Biologics Ireland Ltd
Publication of IL273389A publication Critical patent/IL273389A/en
Publication of IL273389B1 publication Critical patent/IL273389B1/en
Publication of IL273389B2 publication Critical patent/IL273389B2/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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IL273389A 2017-09-21 2018-09-20 Novel anti-cd19 antibodies IL273389B2 (en)

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CN111303287B (zh) * 2019-12-05 2022-05-20 常州费洛斯药业科技有限公司 一种anti-CD19的全人源抗体或抗体片段及其嵌合抗原受体和应用
CN115916818A (zh) 2019-12-11 2023-04-04 库利南肿瘤股份有限公司 抗cd19抗体和多特异性结合蛋白
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆（苏州）医学科技有限公司 可结合cd19的多肽及其应用
CA3176425A1 (en) * 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof
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WO2022266075A1 (en) 2021-06-14 2022-12-22 Caribou Biosciences, Inc. Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain
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