AU2018336520B2 - Novel anti-CD19 antibodies - Google Patents

Novel anti-CD19 antibodies Download PDF

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AU2018336520B2
AU2018336520B2 AU2018336520A AU2018336520A AU2018336520B2 AU 2018336520 B2 AU2018336520 B2 AU 2018336520B2 AU 2018336520 A AU2018336520 A AU 2018336520A AU 2018336520 A AU2018336520 A AU 2018336520A AU 2018336520 B2 AU2018336520 B2 AU 2018336520B2
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seq
antibody
ser
antigen
gly
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AU2018336520A1 (en
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Jing Li
Jieying Liu
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Wuxi Biologics Ireland Ltd
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Wuxi Biologics Ireland Ltd
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
CN110003334B (zh) * 2019-04-12 2023-05-09 深圳普瑞金生物药业股份有限公司 多肽、cd19单域抗体及其制备方法、核苷酸序列及试剂盒
EP4038194A1 (en) 2019-10-04 2022-08-10 Ultragenyx Pharmaceutical Inc. Methods for improved therapeutic use of recombinant aav
CN111303286B (zh) * 2019-12-05 2022-05-20 常州费洛斯药业科技有限公司 一种anti-CD19的全人源抗体或抗体片段及其嵌合抗原受体和应用
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆（苏州）医学科技有限公司 可结合cd19的多肽及其应用
CA3176425A1 (en) 2020-04-24 2021-10-28 Millennium Pharmaceuticals, Inc. Anti-cd19 antibodies and uses thereof
CN111840571B (zh) * 2020-08-03 2022-09-20 杭州皓阳生物技术有限公司 一种抗体药物偶联物及其用途
WO2022266075A1 (en) 2021-06-14 2022-12-22 Caribou Biosciences, Inc. Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain
WO2023280297A1 (zh) * 2021-07-09 2023-01-12 江苏先声药业有限公司 Cd19抗体及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009052431A2 (en) * 2007-10-19 2009-04-23 Seattle Genetics, Inc. Cd19 binding agents and uses thereof
WO2009054863A2 (en) * 2006-12-13 2009-04-30 Medarex, Inc. Human antibodies that bind cd19 and uses thereof
WO2012156455A1 (en) * 2011-05-17 2012-11-22 Sanofi Use of anti-cd19 maytansinoid immunoconjugate antibody for the treatment of b-cell malignancies symptoms
WO2017055328A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-human cd19 antibodies with high affinity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080260731A1 (en) * 2002-03-01 2008-10-23 Bernett Matthew J Optimized antibodies that target cd19
EP2216342B1 (en) * 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 antibodies
CN101233156B (zh) * 2005-06-20 2012-06-27 米德列斯公司 Cd19抗体及其用途
HRP20140331T1 (hr) * 2006-08-14 2014-05-09 Xencor, Inc. Optimizirana antitijela usmjerena na cd19
MX2009002414A (es) * 2006-09-08 2009-05-20 Medimmune Llc Anticuerpos anti-cd19 humanizados y su uso en el tratamiento de oncologia, transplante y enfermedad autoinmunitaria.
EP2398829A2 (en) 2009-02-23 2011-12-28 Glenmark Pharmaceuticals S.A. Humanized antibodies that bind to cd19 and their uses
EP2409712A1 (en) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile
EP2409993A1 (en) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC function with improved glycosylation profile
WO2014065402A1 (ja) * 2012-10-26 2014-05-01 株式会社ペルセウスプロテオミクス 抗ヒトｃｄ４０モノクローナル抗体及びその利用
DK2900277T3 (da) * 2012-12-13 2022-04-04 Immunomedics Inc Doser af immunokonjugater af antistoffer og sn-38 til forbedret effektivitet og reduceret toksicitet
US9758575B2 (en) * 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
CN109476749A (zh) 2016-06-30 2019-03-15 豪夫迈·罗氏有限公司 改良的过继性t细胞疗法
AU2019282836B2 (en) * 2018-06-07 2025-09-04 Cullinan Oncology, Inc. Multi-specific binding proteins and methods of use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054863A2 (en) * 2006-12-13 2009-04-30 Medarex, Inc. Human antibodies that bind cd19 and uses thereof
WO2009052431A2 (en) * 2007-10-19 2009-04-23 Seattle Genetics, Inc. Cd19 binding agents and uses thereof
US8242252B2 (en) * 2007-10-19 2012-08-14 Seattle Genetics, Inc. CD19 binding agents and uses thereof
WO2012156455A1 (en) * 2011-05-17 2012-11-22 Sanofi Use of anti-cd19 maytansinoid immunoconjugate antibody for the treatment of b-cell malignancies symptoms
WO2017055328A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-human cd19 antibodies with high affinity

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