IL273172B1 - RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression - Google Patents

RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression

Info

Publication number
IL273172B1
IL273172B1 IL273172A IL27317220A IL273172B1 IL 273172 B1 IL273172 B1 IL 273172B1 IL 273172 A IL273172 A IL 273172A IL 27317220 A IL27317220 A IL 27317220A IL 273172 B1 IL273172 B1 IL 273172B1
Authority
IL
Israel
Prior art keywords
apoc3
apolipoprotein
compositions
iii
rnai agents
Prior art date
Application number
IL273172A
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English (en)
Hebrew (he)
Other versions
IL273172A (en
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of IL273172A publication Critical patent/IL273172A/en
Publication of IL273172B1 publication Critical patent/IL273172B1/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IL273172A 2017-09-11 2020-03-09 RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression IL273172B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21
PCT/US2018/050248 WO2019051402A1 (en) 2017-09-11 2018-09-10 RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3)

Publications (2)

Publication Number Publication Date
IL273172A IL273172A (en) 2020-04-30
IL273172B1 true IL273172B1 (en) 2025-12-01

Family

ID=65630632

Family Applications (2)

Application Number Title Priority Date Filing Date
IL273172A IL273172B1 (en) 2017-09-11 2020-03-09 RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression
IL324223A IL324223A (en) 2017-09-11 2025-10-26 RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL324223A IL324223A (en) 2017-09-11 2025-10-26 RNAi materials and preparations for suppressing apolipoprotein C-III (APOC3) expression

Country Status (24)

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US (4) US10597657B2 (OSRAM)
EP (1) EP3681516A4 (OSRAM)
JP (2) JP7438103B2 (OSRAM)
KR (2) KR102723833B1 (OSRAM)
CN (2) CN118879696A (OSRAM)
AU (1) AU2018329190B2 (OSRAM)
BR (1) BR112020002413A2 (OSRAM)
CA (1) CA3074303A1 (OSRAM)
CL (2) CL2020000593A1 (OSRAM)
CO (1) CO2020002586A2 (OSRAM)
CR (1) CR20200108A (OSRAM)
EC (1) ECSP20017905A (OSRAM)
IL (2) IL273172B1 (OSRAM)
JO (1) JOP20200054A1 (OSRAM)
MX (1) MX2020002648A (OSRAM)
MY (1) MY202025A (OSRAM)
PE (1) PE20201283A1 (OSRAM)
PH (1) PH12020500332A1 (OSRAM)
SG (1) SG11201912178VA (OSRAM)
TN (1) TN2020000039A1 (OSRAM)
TW (2) TW202415389A (OSRAM)
UY (1) UY37871A (OSRAM)
WO (1) WO2019051402A1 (OSRAM)
ZA (1) ZA202100806B (OSRAM)

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