IL271950B2 - Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one - Google Patents
Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-oneInfo
- Publication number
- IL271950B2 IL271950B2 IL271950A IL27195020A IL271950B2 IL 271950 B2 IL271950 B2 IL 271950B2 IL 271950 A IL271950 A IL 271950A IL 27195020 A IL27195020 A IL 27195020A IL 271950 B2 IL271950 B2 IL 271950B2
- Authority
- IL
- Israel
- Prior art keywords
- mixture
- solution
- composition
- crystalline form
- crystalline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762533509P | 2017-07-17 | 2017-07-17 | |
| PCT/IB2018/000875 WO2019038583A1 (en) | 2017-07-17 | 2018-07-16 | 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2-ONE POLYMORPHS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL271950A IL271950A (en) | 2020-02-27 |
| IL271950B1 IL271950B1 (en) | 2024-02-01 |
| IL271950B2 true IL271950B2 (en) | 2024-06-01 |
Family
ID=63517924
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL271950A IL271950B2 (en) | 2017-07-17 | 2018-07-16 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one |
| IL309708A IL309708B2 (en) | 2017-07-17 | 2018-07-16 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323268A IL323268A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323267A IL323267A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323266A IL323266A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL309708A IL309708B2 (en) | 2017-07-17 | 2018-07-16 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323268A IL323268A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323267A IL323267A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| IL323266A IL323266A (en) | 2017-07-17 | 2025-09-10 | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11632954B2 (https=) |
| EP (1) | EP3655396A1 (https=) |
| JP (3) | JP2020527563A (https=) |
| CN (2) | CN118515619A (https=) |
| AR (1) | AR112276A1 (https=) |
| AU (1) | AU2018320492C1 (https=) |
| CA (1) | CA3069619A1 (https=) |
| IL (5) | IL271950B2 (https=) |
| MA (1) | MA49639A (https=) |
| WO (1) | WO2019038583A1 (https=) |
| ZA (1) | ZA202000411B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20212103A1 (es) | 2018-11-05 | 2021-11-04 | Adama Makhteshim Ltd | Mezclas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona, y metodos de uso de los mismos |
| CN114901073A (zh) * | 2019-07-22 | 2022-08-12 | 阿达马蒂斯有限公司 | 杀真菌组合、混合物和组合物及其用途 |
| PY2057637A (es) * | 2019-09-23 | 2021-10-05 | Adama Makhteshim Ltd | Proceso para preparar 5-(fluoro-4-imino-3-metil)-1-tosil-3,4-dihidropirimidin-(1h)-ona y derivados del compuesto |
| IL297864A (en) * | 2020-05-04 | 2023-01-01 | Adama Makhteshim Ltd | Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof |
| CA3206570A1 (en) | 2021-01-27 | 2022-08-04 | Alexandra ROSENMUND | 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1 h)-one for controlling plant diseases |
| IL308155A (en) | 2021-05-04 | 2024-01-01 | Adama Makhteshim Ltd | Crystalline forms of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one and mixtures, compositions and methods of using them |
| UY40172A (es) | 2022-03-03 | 2023-10-13 | Adama Makhteshim Ltd | Combinaciones, mezclas y composiciones fungicidas y usos de las mismas |
| AU2023275068A1 (en) | 2022-05-26 | 2024-11-28 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereof |
| TW202412625A (zh) | 2022-08-03 | 2024-04-01 | 以色列商安道麥馬克西姆有限公司 | 用於抗殺真菌劑真菌的5-氟-4-亞胺基-3-甲基-1-甲苯磺醯基-3,4-二氫嘧啶-2(1h)-酮 |
| CN120882310A (zh) | 2023-03-09 | 2025-10-31 | 安道麦马克西姆有限公司 | 杀真菌组合、混合物及组合物以及其用途 |
| EP4680029A1 (en) | 2023-03-14 | 2026-01-21 | Adama Makhteshim Ltd. | Liquid compositions containing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1h)-one and derivatives thereof and a uv absorber |
| AR132381A1 (es) | 2023-04-11 | 2025-06-18 | Adama Makhteshim Ltd | Compuestos y procesos relativos a flumetilsulforim |
| WO2025046581A1 (en) | 2023-08-31 | 2025-03-06 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereo |
| PY24105707A (es) | 2023-11-28 | 2025-06-25 | Adama Makhteshim Ltd | Combinaciones, mezclas y composiciones fungicidas y usos de las mismas |
| WO2026038217A1 (en) | 2024-08-15 | 2026-02-19 | Adama Makhteshim Ltd. | Mixtures and compositions comprising flumetylsulforim and methods of use thereof |
| WO2026083410A1 (en) | 2024-10-15 | 2026-04-23 | Adama Makhteshim Ltd. | Mixtures and composition comprising thereof |
| WO2026083211A1 (en) | 2024-10-16 | 2026-04-23 | Adama Makhteshim Ltd. | Mixtures and composition comprising thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008093325A2 (en) * | 2007-02-01 | 2008-08-07 | Makhteshim Chemical Works Ltd. | Polymorphs of 3-(e)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate |
| US20150183749A1 (en) * | 2013-12-31 | 2015-07-02 | Dow Agrosciences Llc | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
| WO2016106138A1 (en) * | 2014-12-23 | 2016-06-30 | Dow Agrosciences Llc | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one as a seed treatment |
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| US3309359A (en) | 1965-10-22 | 1967-03-14 | Hoffmann La Roche | N-mono-acyl-5-fluorocytosine derivatives and process |
| US3368938A (en) | 1966-01-13 | 1968-02-13 | Hoffmann La Roche | Controlling fungi with 5-fluorocytosine |
| US3635977A (en) | 1969-11-03 | 1972-01-18 | American Cyanamid Co | Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil |
| US3868373A (en) | 1970-01-27 | 1975-02-25 | Hoffmann La Roche | 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines |
| US4009272A (en) | 1971-10-23 | 1977-02-22 | Bayer Aktiengesellschaft | Penicillins |
| US4845081A (en) | 1984-10-18 | 1989-07-04 | University Of Florida | Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes |
| DE3821711A1 (de) | 1988-06-28 | 1990-02-08 | Bayer Ag | Thiazolopyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| JP3217191B2 (ja) | 1992-07-16 | 2001-10-09 | ビーエーエスエフ アクチェンゲゼルシャフト | ヘテロ芳香族化合物およびこれを含有する植物保護剤 |
| JP4010563B2 (ja) | 1995-07-05 | 2007-11-21 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 殺菌・殺カビ性のピリミジノン類 |
| GT199900185A (es) | 1998-11-06 | 2001-04-18 | Novedosa pirimidin-4-enamina como fungicida. | |
| WO2003018051A1 (en) | 2001-08-27 | 2003-03-06 | Vic Jira | Anti-fungal composition |
| JPWO2005095419A1 (ja) | 2004-04-01 | 2008-02-21 | 武田薬品工業株式会社 | チアゾロピリミジン誘導体 |
| JP4887500B2 (ja) | 2004-09-16 | 2012-02-29 | 国立大学法人岐阜大学 | ヌクレオシド類似体またはその塩 |
| PT1909579E (pt) | 2005-07-27 | 2016-02-10 | Basf Se | Misturas fungicidas com base em azolopirimidinilaminas |
| TWI402034B (zh) | 2005-07-28 | 2013-07-21 | Dow Agrosciences Llc | 具有被層狀液晶覆膜包覆之油球之水包油乳化劑之農用組成物 |
| IL172137A0 (en) * | 2005-11-23 | 2006-04-10 | Maktheshim Chemical Works Ltd | Process for prep aring pyridinamines |
| US20080004253A1 (en) | 2006-06-30 | 2008-01-03 | Bryan James Branstetter | Thiazolopyrimidine modulators of TRPV1 |
| US20100029483A1 (en) | 2006-10-16 | 2010-02-04 | Rhodia Inc. | Agricultural adjuvant compositions, pesticide compositions, and methods for using such compositions |
| US8093245B2 (en) | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use |
| MX2009008531A (es) | 2007-02-16 | 2009-08-26 | Amgen Inc | Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met. |
| EP2562163A1 (en) | 2008-01-22 | 2013-02-27 | Dow AgroSciences LLC | 5-fluoro pyrimidine derivatives as fungicides |
| US20100284959A1 (en) | 2008-01-23 | 2010-11-11 | Gene Arrest Ltd. | Sequence specific double-stranded dna/rna binding compounds and uses thereof |
| KR20110042204A (ko) | 2008-08-01 | 2011-04-25 | 다우 아그로사이언시즈 엘엘씨 | 살진균제로서의 5-플루오로시토신의 용도 |
| WO2010145999A2 (de) | 2009-06-18 | 2010-12-23 | Basf Se | Fungizide mischungen |
| BR112012002807B1 (pt) | 2009-08-07 | 2018-07-10 | Adama Makhteshim Ltd. | Derivados de 5-flúor-2-oxopirimidina-1(2h)- caboxilato, composição e processo para controle e prevenção de ataque fúngico em uma planta de ataque fúngico em uma planta |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| DK2462134T3 (da) | 2009-08-07 | 2014-08-11 | Dow Agrosciences Llc | N1-sulfonyl-5-fluorpyrimidinonderivater |
| WO2011043876A1 (en) | 2009-10-07 | 2011-04-14 | Dow Agrosciences Llc | Synergistic fungicidal composition containing 5-fluorocytosine for fungal control in cereals |
| PL2563129T3 (pl) | 2010-04-26 | 2017-08-31 | Adama Makhteshim Ltd | N3-podstawione pochodne n1-sulfonylo-5-fluoropirymidynonu |
| US20120208700A1 (en) | 2011-02-11 | 2012-08-16 | Dow Agrosciences Llc | Stable agrochemical oil dispersions |
| SI2775842T1 (en) | 2011-08-17 | 2018-01-31 | Adama Makhteshim Ltd. | 1-substituted-5-fluoro-3,6-dihydro-6-imino-2 (1H) -pyrimidinone derivatives as fungicidal agents for use in plant protection |
| RU2018118951A (ru) | 2012-12-28 | 2018-11-02 | Адама Мактешим Лтд. | Производные 1-(замещенный бензоил)-5-фтор-4-имино-3-метил-3,4-дигидропиримидин-2(1h)-она |
| KR20150100869A (ko) | 2012-12-28 | 2015-09-02 | 다우 아그로사이언시즈 엘엘씨 | N-(치환된)-5-플루오로-4-이미노-3-메틸-2-옥소-3,4-디히드로피리미딘-1(2h)-카르복스아미드 유도체 |
| CN105007737A (zh) | 2012-12-31 | 2015-10-28 | 美国陶氏益农公司 | 作为杀真菌剂的3-烷基-5-氟-4-取代的-亚氨基-3,4-二氢嘧啶-2(1h)-酮衍生物 |
| TWI652012B (zh) * | 2013-05-20 | 2019-03-01 | 杜邦股份有限公司 | 殺真菌吡唑的固態形式 |
| CN114794123B (zh) | 2013-12-31 | 2024-11-12 | 阿达玛马克西姆股份有限公司 | 用防治谷类中真菌的协同杀真菌混合物 |
-
2018
- 2018-07-16 MA MA049639A patent/MA49639A/fr unknown
- 2018-07-16 CN CN202410543394.9A patent/CN118515619A/zh active Pending
- 2018-07-16 IL IL271950A patent/IL271950B2/en unknown
- 2018-07-16 CA CA3069619A patent/CA3069619A1/en active Pending
- 2018-07-16 EP EP18765708.5A patent/EP3655396A1/en active Pending
- 2018-07-16 CN CN201880059865.1A patent/CN111094252B/zh active Active
- 2018-07-16 AU AU2018320492A patent/AU2018320492C1/en active Active
- 2018-07-16 JP JP2020502159A patent/JP2020527563A/ja active Pending
- 2018-07-16 WO PCT/IB2018/000875 patent/WO2019038583A1/en not_active Ceased
- 2018-07-16 US US16/632,068 patent/US11632954B2/en active Active
- 2018-07-16 IL IL309708A patent/IL309708B2/en unknown
- 2018-07-17 AR ARP180101983 patent/AR112276A1/es unknown
-
2020
- 2020-01-21 ZA ZA2020/00411A patent/ZA202000411B/en unknown
-
2023
- 2023-07-21 JP JP2023118871A patent/JP2023145572A/ja active Pending
-
2025
- 2025-07-25 JP JP2025124685A patent/JP2025163080A/ja active Pending
- 2025-09-10 IL IL323268A patent/IL323268A/en unknown
- 2025-09-10 IL IL323267A patent/IL323267A/en unknown
- 2025-09-10 IL IL323266A patent/IL323266A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008093325A2 (en) * | 2007-02-01 | 2008-08-07 | Makhteshim Chemical Works Ltd. | Polymorphs of 3-(e)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate |
| US20150183749A1 (en) * | 2013-12-31 | 2015-07-02 | Dow Agrosciences Llc | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
| WO2016106138A1 (en) * | 2014-12-23 | 2016-06-30 | Dow Agrosciences Llc | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one as a seed treatment |
Non-Patent Citations (2)
| Title |
|---|
| CAIRA ED - MONTCHAMP JEAN-LUC,, CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS, 31 December 1998 (1998-12-31) * |
| HARWOOD L M ET AL, EXPERIMENTAL ORGANIC CHEMISTRY - PRINCIPLES AND PRACTI, 31 December 1989 (1989-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ761039A (en) | 2023-09-29 |
| CA3069619A1 (en) | 2019-02-28 |
| CN111094252A (zh) | 2020-05-01 |
| WO2019038583A1 (en) | 2019-02-28 |
| IL271950B1 (en) | 2024-02-01 |
| ZA202000411B (en) | 2023-10-25 |
| IL309708B1 (en) | 2025-10-01 |
| IL271950A (en) | 2020-02-27 |
| CN111094252B (zh) | 2024-05-24 |
| AR112276A1 (es) | 2019-10-09 |
| IL323266A (en) | 2025-11-01 |
| MA49639A (fr) | 2020-05-27 |
| BR112020000953A2 (pt) | 2020-07-14 |
| AU2018320492A1 (en) | 2020-02-13 |
| IL323267A (en) | 2025-11-01 |
| EP3655396A1 (en) | 2020-05-27 |
| JP2025163080A (ja) | 2025-10-28 |
| IL309708A (en) | 2024-02-01 |
| AU2018320492B2 (en) | 2022-12-01 |
| CN118515619A (zh) | 2024-08-20 |
| JP2020527563A (ja) | 2020-09-10 |
| IL323268A (en) | 2025-11-01 |
| JP2023145572A (ja) | 2023-10-11 |
| US20200229437A1 (en) | 2020-07-23 |
| AU2018320492C1 (en) | 2023-07-13 |
| US11632954B2 (en) | 2023-04-25 |
| IL309708B2 (en) | 2026-02-01 |
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