IL269293B - Fused bicyclic 6-6 heteroaryl compounds and their use as lats inhibitors - Google Patents

Fused bicyclic 6-6 heteroaryl compounds and their use as lats inhibitors

Info

Publication number
IL269293B
IL269293B IL269293A IL26929319A IL269293B IL 269293 B IL269293 B IL 269293B IL 269293 A IL269293 A IL 269293A IL 26929319 A IL26929319 A IL 26929319A IL 269293 B IL269293 B IL 269293B
Authority
IL
Israel
Prior art keywords
bicyclic heteroaryl
fused bicyclic
heteroaryl compounds
lats inhibitors
lats
Prior art date
Application number
IL269293A
Other languages
English (en)
Hebrew (he)
Other versions
IL269293A (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL269293A publication Critical patent/IL269293A/en
Publication of IL269293B publication Critical patent/IL269293B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
    • C12N15/8645—Adeno-associated virus
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2510/00—Genetically modified cells

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IL269293A 2017-04-28 2019-09-11 Fused bicyclic 6-6 heteroaryl compounds and their use as lats inhibitors IL269293B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762491484P 2017-04-28 2017-04-28
US201762491475P 2017-04-28 2017-04-28
US201762491526P 2017-04-28 2017-04-28
US201762491573P 2017-04-28 2017-04-28
US201862650232P 2018-03-29 2018-03-29
PCT/IB2018/052919 WO2018198077A2 (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Publications (2)

Publication Number Publication Date
IL269293A IL269293A (en) 2019-11-28
IL269293B true IL269293B (en) 2022-06-01

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Family Applications (2)

Application Number Title Priority Date Filing Date
IL269293A IL269293B (en) 2017-04-28 2019-09-11 Fused bicyclic 6-6 heteroaryl compounds and their use as lats inhibitors
IL292857A IL292857A (en) 2017-04-28 2022-05-09 Dicyclic fused 6-6 heteroaryl compounds and their use as lats inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL292857A IL292857A (en) 2017-04-28 2022-05-09 Dicyclic fused 6-6 heteroaryl compounds and their use as lats inhibitors

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US (2) US11458138B2 (cg-RX-API-DMAC7.html)
EP (1) EP3615537B1 (cg-RX-API-DMAC7.html)
JP (2) JP7247102B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190142776A (cg-RX-API-DMAC7.html)
CN (3) CN110573511B (cg-RX-API-DMAC7.html)
AU (2) AU2018260495B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019022512A2 (cg-RX-API-DMAC7.html)
CA (1) CA3056906A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019003049A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019011873A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190483A (cg-RX-API-DMAC7.html)
CU (2) CU20200080A7 (cg-RX-API-DMAC7.html)
DO (1) DOP2019000273A (cg-RX-API-DMAC7.html)
EC (1) ECSP19076732A (cg-RX-API-DMAC7.html)
ES (1) ES2983611T3 (cg-RX-API-DMAC7.html)
IL (2) IL269293B (cg-RX-API-DMAC7.html)
JO (1) JOP20190257A1 (cg-RX-API-DMAC7.html)
MA (1) MA49285A (cg-RX-API-DMAC7.html)
MX (1) MX2019012756A (cg-RX-API-DMAC7.html)
PE (1) PE20200292A1 (cg-RX-API-DMAC7.html)
PH (1) PH12019502436A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201908615RA (cg-RX-API-DMAC7.html)
TW (1) TW201843140A (cg-RX-API-DMAC7.html)
UY (1) UY37703A (cg-RX-API-DMAC7.html)
WO (1) WO2018198077A2 (cg-RX-API-DMAC7.html)

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