IL268415B - Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparation - Google Patents
Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparationInfo
- Publication number
- IL268415B IL268415B IL268415A IL26841519A IL268415B IL 268415 B IL268415 B IL 268415B IL 268415 A IL268415 A IL 268415A IL 26841519 A IL26841519 A IL 26841519A IL 268415 B IL268415 B IL 268415B
- Authority
- IL
- Israel
- Prior art keywords
- making
- methods
- same
- opioid receptor
- modulating compounds
- Prior art date
Links
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 108700023159 delta Opioid Receptors Proteins 0.000 title 1
- 102000048124 delta Opioid Receptors Human genes 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460386P | 2017-02-17 | 2017-02-17 | |
| PCT/US2018/018303 WO2018152286A1 (en) | 2017-02-17 | 2018-02-15 | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL268415A IL268415A (en) | 2019-09-26 |
| IL268415B true IL268415B (en) | 2022-06-01 |
Family
ID=63170722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL268415A IL268415B (en) | 2017-02-17 | 2019-08-01 | Delta-opioid receptor modulator compounds containing 7-atom aza-heterocycles, methods for their use and preparation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11225487B2 (https=) |
| EP (1) | EP3582783B1 (https=) |
| JP (1) | JP7185633B2 (https=) |
| KR (1) | KR102662065B1 (https=) |
| CN (1) | CN110446495B (https=) |
| AU (1) | AU2018221705B2 (https=) |
| BR (1) | BR112019016775A2 (https=) |
| CA (1) | CA3052479A1 (https=) |
| IL (1) | IL268415B (https=) |
| WO (1) | WO2018152286A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018221148B2 (en) | 2017-02-17 | 2022-05-05 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN119285615B (zh) * | 2024-09-29 | 2025-09-19 | 广东医科大学 | 一种生物碱类化合物在制备具有抗ⅱ型单纯疱疹病毒作用的药物中的应用 |
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| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| AU2018221148B2 (en) | 2017-02-17 | 2022-05-05 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| JP7252908B2 (ja) * | 2017-06-14 | 2023-04-05 | トレベナ・インコーポレイテッド | Ｓ１ｐ１活性を調節するための化合物およびその使用法 |
| JP2021500334A (ja) | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法 |
| CN111138425A (zh) | 2020-01-06 | 2020-05-12 | 中国药科大学 | 三氮唑类衍生物及其制备方法与用途 |
| WO2022093904A1 (en) | 2020-10-27 | 2022-05-05 | Trevena, Inc. | Crystalline and amorphous forms of a delta-opioid modulator |
| WO2023070605A1 (en) | 2021-10-29 | 2023-05-04 | Trevena, Inc. | Methods of preparing 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds |
-
2018
- 2018-02-15 CN CN201880018666.6A patent/CN110446495B/zh not_active Expired - Fee Related
- 2018-02-15 WO PCT/US2018/018303 patent/WO2018152286A1/en not_active Ceased
- 2018-02-15 CA CA3052479A patent/CA3052479A1/en active Pending
- 2018-02-15 BR BR112019016775-7A patent/BR112019016775A2/pt not_active Application Discontinuation
- 2018-02-15 JP JP2019544622A patent/JP7185633B2/ja active Active
- 2018-02-15 EP EP18753604.0A patent/EP3582783B1/en active Active
- 2018-02-15 US US16/486,539 patent/US11225487B2/en not_active Expired - Fee Related
- 2018-02-15 KR KR1020197026924A patent/KR102662065B1/ko active Active
- 2018-02-15 AU AU2018221705A patent/AU2018221705B2/en not_active Ceased
-
2019
- 2019-08-01 IL IL268415A patent/IL268415B/en unknown
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2021
- 2021-11-22 US US17/532,413 patent/US11912713B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11912713B2 (en) | 2024-02-27 |
| US11225487B2 (en) | 2022-01-18 |
| AU2018221705B2 (en) | 2022-10-27 |
| US20210061812A1 (en) | 2021-03-04 |
| EP3582783A4 (en) | 2020-09-02 |
| AU2018221705A1 (en) | 2019-08-29 |
| JP7185633B2 (ja) | 2022-12-07 |
| WO2018152286A1 (en) | 2018-08-23 |
| CA3052479A1 (en) | 2018-08-23 |
| BR112019016775A2 (pt) | 2020-03-31 |
| IL268415A (en) | 2019-09-26 |
| KR20190117658A (ko) | 2019-10-16 |
| CN110446495B (zh) | 2023-09-05 |
| KR102662065B1 (ko) | 2024-05-07 |
| EP3582783A1 (en) | 2019-12-25 |
| EP3582783B1 (en) | 2023-06-07 |
| JP2020508301A (ja) | 2020-03-19 |
| CN110446495A (zh) | 2019-11-12 |
| US20220348588A1 (en) | 2022-11-03 |
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