IL268125B2 - Pridopidine for the treatment of fragile x syndrome - Google Patents
Pridopidine for the treatment of fragile x syndromeInfo
- Publication number
- IL268125B2 IL268125B2 IL268125A IL26812519A IL268125B2 IL 268125 B2 IL268125 B2 IL 268125B2 IL 268125 A IL268125 A IL 268125A IL 26812519 A IL26812519 A IL 26812519A IL 268125 B2 IL268125 B2 IL 268125B2
- Authority
- IL
- Israel
- Prior art keywords
- pridopidine
- pharmaceutical composition
- fxs
- subject
- amount
- Prior art date
Links
- 208000001914 Fragile X syndrome Diseases 0.000 title claims description 111
- YGKUEOZJFIXDGI-UHFFFAOYSA-N pridopidine Chemical compound C1CN(CCC)CCC1C1=CC=CC(S(C)(=O)=O)=C1 YGKUEOZJFIXDGI-UHFFFAOYSA-N 0.000 title claims description 108
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- 238000011282 treatment Methods 0.000 title claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 47
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims description 24
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| AU2011298382A1 (en) | 2010-09-03 | 2013-05-02 | Teva Pharmaceuticals International Gmbh | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
| US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
| MX2019002190A (es) | 2016-08-24 | 2019-09-11 | Prilenia Therapeutics Dev Ltd | Uso de pridopidina para tratar distonías. |
| IL311081A (en) | 2016-08-24 | 2024-04-01 | Prilenia Neurotherapeutics Ltd | Use of pyridofidine to treat functional decline |
| US12102627B2 (en) | 2016-09-16 | 2024-10-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating rett syndrome |
| US12036213B2 (en) | 2017-09-08 | 2024-07-16 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
| AU2018329628B2 (en) | 2017-09-08 | 2021-04-22 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
| EP3920924A4 (en) | 2019-02-04 | 2022-11-16 | Prilenia Neurotherapeutics Ltd. | LOW-DOSE PRIDOIDIN FOR THE TREATMENT OF PARKINSON'S DISEASE AND OTHER PARKINSONIC-RELATED DISEASES |
| EP4088721B1 (en) * | 2020-01-08 | 2025-09-17 | Neuroventi | Composition for treating fragile x syndrome or related developmental disorders, comprising lisuride compound as active ingredient |
| CN116472043A (zh) * | 2020-10-20 | 2023-07-21 | 普瑞尼亚神经治疗有限公司 | 普利多匹定和类似物用于治疗焦虑和抑郁的用途 |
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| WO2001046145A1 (en) * | 1999-12-22 | 2001-06-28 | A. Carlsson Research Ab | New modulators of dopamine neurotransmission |
| WO2016138130A1 (en) * | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Use of pridopidine to improve cognitive function and for treating alzheimer's disease |
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| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| AU2005293754B2 (en) | 2004-10-13 | 2011-07-21 | Teva Pharmaceuticals International Gmbh | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine |
| DK2146961T3 (da) | 2007-04-12 | 2014-04-28 | Ivax Int Gmbh | N-oxid- og/eller di-N-oxidderivater af dopaminreceptorstabilisatorer/modulatorer udvisende forbedrede cardiovaskulære bivirkningsprofiler |
| WO2008133884A2 (en) | 2007-04-23 | 2008-11-06 | Combinatorx, Incorporated | Methods and compositions for the treatment of neurodegenerative disorders |
| CN103080343A (zh) | 2010-07-02 | 2013-05-01 | Skf公司 | 机械部件和用于表面硬化的方法 |
| AU2011298382A1 (en) | 2010-09-03 | 2013-05-02 | Teva Pharmaceuticals International Gmbh | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
| BR112013018898B1 (pt) * | 2011-01-27 | 2021-10-05 | Neuren Pharmaceuticals Limited | Uso de ácido glicil-l-2-metilprolil-l-glutâmico e análogos do mesmo para o tratamento de transtornos do espectro do autismo |
| KR20140075703A (ko) | 2011-09-07 | 2014-06-19 | 아이백스 인터내셔널 게엠베하 | 프리도피딘 하이드로클로라이드의 다형 형태 |
| US9012476B2 (en) | 2011-12-08 | 2015-04-21 | IVAX International GmbH | Hydrobromide salt of pridopidine |
| JP6177875B2 (ja) | 2012-04-04 | 2017-08-09 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ | 併用療法のための医薬組成物 |
| HK1211483A1 (en) * | 2012-09-27 | 2016-05-27 | Teva Pharmaceutical Industries Ltd. | Combination of rasagiline and pridopidine for treating neurodegenerative disorders, in particular huntington's disease |
| KR102316933B1 (ko) | 2013-06-21 | 2021-10-26 | 프리레니아 뉴로테라퓨틱스 엘티디. | 헌팅턴병 치료를 위한 프리도피딘의 용도 |
| DK3096759T3 (da) | 2014-01-22 | 2022-05-09 | Prilenia Neurotherapeutics Ltd | Pridopidinformuleringer med modificeret frigivelse |
| TW201613859A (en) * | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| JP2018505147A (ja) | 2014-12-22 | 2018-02-22 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー | プリドピジンのｌ−酒石酸塩 |
| WO2016138135A1 (en) | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Sigma-1 receptor modulators for treating huntington's disease |
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2018
- 2018-01-18 HU HUE18741607A patent/HUE068300T2/hu unknown
- 2018-01-18 ES ES18741607T patent/ES2972205T3/es active Active
- 2018-01-18 WO PCT/US2018/014169 patent/WO2018136600A1/en not_active Ceased
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046145A1 (en) * | 1999-12-22 | 2001-06-28 | A. Carlsson Research Ab | New modulators of dopamine neurotransmission |
| WO2016138130A1 (en) * | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Use of pridopidine to improve cognitive function and for treating alzheimer's disease |
Non-Patent Citations (1)
| Title |
|---|
| HAMPSON D. R.ET AL.:, THE NEUROCHEMICAL BASIS FOR THE TREATMENT OF AUTISM SPECTRUM DISORDERS AND FRAGILE X SYNDROME, 17 February 2011 (2011-02-17) * |
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| WO2018136600A1 (en) | 2018-07-26 |
| HUE068300T2 (hu) | 2024-12-28 |
| IL268125A (en) | 2019-09-26 |
| US11234973B2 (en) | 2022-02-01 |
| CA3050700C (en) | 2023-10-03 |
| PL3570940T3 (pl) | 2024-06-17 |
| ES2972205T3 (es) | 2024-06-11 |
| BR112019015000A2 (pt) | 2020-04-07 |
| JP2020514313A (ja) | 2020-05-21 |
| IL268125B (en) | 2022-12-01 |
| US20190336488A1 (en) | 2019-11-07 |
| AU2018210145B2 (en) | 2023-06-29 |
| AU2018210145A1 (en) | 2019-08-29 |
| CN110505902B (zh) | 2022-11-11 |
| CN110505902A (zh) | 2019-11-26 |
| JP7114604B2 (ja) | 2022-08-08 |
| EP3570940A4 (en) | 2020-10-28 |
| DK3570940T3 (da) | 2024-02-19 |
| EP3570940A1 (en) | 2019-11-27 |
| CA3050700A1 (en) | 2018-07-26 |
| EP3570940B1 (en) | 2023-12-13 |
| US20220202798A1 (en) | 2022-06-30 |
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