IL263450B - Boronic acid derivatives and their medicinal uses - Google Patents
Boronic acid derivatives and their medicinal usesInfo
- Publication number
- IL263450B IL263450B IL263450A IL26345018A IL263450B IL 263450 B IL263450 B IL 263450B IL 263450 A IL263450 A IL 263450A IL 26345018 A IL26345018 A IL 26345018A IL 263450 B IL263450 B IL 263450B
- Authority
- IL
- Israel
- Prior art keywords
- acid derivatives
- boronic acid
- therapeutic uses
- therapeutic
- boronic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357165P | 2016-06-30 | 2016-06-30 | |
| PCT/US2017/039787 WO2018005662A1 (en) | 2016-06-30 | 2017-06-28 | Boronic acid derivatives and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL263450A IL263450A (en) | 2019-01-31 |
| IL263450B true IL263450B (en) | 2022-01-01 |
Family
ID=60785544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL263450A IL263450B (en) | 2016-06-30 | 2018-12-03 | Boronic acid derivatives and their medicinal uses |
Country Status (23)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3412676T (pt) | 2010-08-10 | 2020-05-19 | Rempex Pharmaceuticals Inc | Derivados cíclicos de éster de ácido borónico, método para a sua preparação e suas utilizações terapêuticas |
| JP6346904B2 (ja) | 2013-01-10 | 2018-06-20 | ベナトルクス ファーマシューティカルズ，インク． | ベータ−ラクタマーゼ阻害剤 |
| CN106687465B (zh) | 2014-06-11 | 2019-04-16 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2017044828A1 (en) | 2015-09-11 | 2017-03-16 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| AU2017290060B2 (en) | 2016-06-30 | 2021-07-22 | Qpex Biopharma, Inc | Boronic acid derivatives and therapeutic uses thereof |
| JOP20190188A1 (ar) | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك |
| CA3055253A1 (en) | 2017-03-06 | 2018-09-13 | VenatoRx Pharmaceuticals, Inc. | Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof |
| EP3630782A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| US11286270B2 (en) | 2017-10-11 | 2022-03-29 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
| EP3781576B1 (en) * | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| MA54319A (fr) * | 2018-11-29 | 2021-10-06 | Venatorx Pharmaceuticals Inc | Compositions mixtes comprenant un inhibiteur de bêta-lactamase et leurs utilisations |
| CN114340639A (zh) * | 2019-06-19 | 2022-04-12 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
| TW202123945A (zh) * | 2019-09-13 | 2021-07-01 | 日商鹽野義製藥股份有限公司 | 具有抗菌作用的醫藥組成物 |
| JP7654554B2 (ja) | 2019-10-25 | 2025-04-01 | 住友ファーマ株式会社 | 新規置換縮環型化合物 |
| EP4121433A4 (en) * | 2020-03-18 | 2024-06-19 | Qpex Biopharma, Inc. | BORIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF |
| US20250002508A1 (en) * | 2020-05-05 | 2025-01-02 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof |
| US20240294554A1 (en) * | 2020-08-20 | 2024-09-05 | Phaeno Therapeutics Co., Ltd | Boracic acid compound |
| CA3212788A1 (en) * | 2021-04-05 | 2022-10-13 | Qpex Biopharma, Inc. | Ceftibuten dosing regimens |
| BR112023017203A2 (pt) | 2021-04-13 | 2023-11-07 | Tuojie Biotech Shanghai Co Ltd | Derivado de ácido bórico que age como inibidor de beta-lactamase |
| CN113150022B (zh) * | 2021-04-23 | 2022-12-06 | 四川大学 | 3-取代五元环状硼酸酯衍生物及其药物组合物和制药用途 |
| IL312198A (en) * | 2021-10-19 | 2024-06-01 | Shanghai Jemincare Pharmaceutical Co Ltd | Tricyclic boronic acid derivative, and preparation method therefor and application thereof |
| WO2023155869A1 (zh) * | 2022-02-18 | 2023-08-24 | 辉诺生物医药科技（杭州）有限公司 | 新的硼酸类化合物的晶型及其制备方法 |
| CN114716465B (zh) * | 2022-05-06 | 2024-05-24 | 上海中医药大学 | 一种双环硼酸酯类化合物的制备方法及其应用 |
| GB202306835D0 (en) | 2023-05-09 | 2023-06-21 | Adjutec Pharma As | Therapy |
| WO2025119216A1 (zh) * | 2023-12-04 | 2025-06-12 | 珠海联邦制药股份有限公司 | 硼酸类β-内酰胺酶抑制剂及其制备方法和应用 |
Family Cites Families (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3686398A (en) * | 1970-07-20 | 1972-08-22 | Chevron Res | 10,9-boroxarophenanthrene as fungicides |
| US4194047A (en) | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
| US4260543A (en) | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
| US4409214A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| US4353807A (en) * | 1981-03-24 | 1982-10-12 | Mobil Oil Corporation | Lubricants and fuels containing boroxarophenanthrene compounds |
| FR2573070B1 (fr) | 1984-11-13 | 1987-01-30 | Rhone Poulenc Sante | Procede de preparation de composes carbonyles |
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| US4822786A (en) | 1986-07-01 | 1989-04-18 | Kaken Pharmaceutical Co., Ltd. | Cephalosporin compounds, and antibacterial agents |
| ZA893284B (en) | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
| US5442100A (en) | 1992-08-14 | 1995-08-15 | The Procter & Gamble Company | β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids |
| US5888998A (en) | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
| WO1998056392A1 (en) | 1997-06-13 | 1998-12-17 | Northwestern University | INHIBITORS OF β-LACTAMASES AND USES THEREFOR |
| US6184363B1 (en) | 1997-06-13 | 2001-02-06 | Northwestern University | Inhibitors of β-lactamases and uses therefor |
| WO2000035904A1 (en) | 1998-12-16 | 2000-06-22 | Northwestern University | INHIBITORS OF β-LACTAMASES AND USES THEREFOR |
| WO2000035905A1 (en) | 1998-12-16 | 2000-06-22 | Northwestern University | INHIBITORS OF β-LACTAMASES AND USES THEREFOR |
| DE60008262T2 (de) | 1999-09-25 | 2004-12-16 | Smithkline Beecham P.L.C., Brentford | Piperazinderivate als 5-ht1b antagonisten |
| WO2001030149A1 (en) | 1999-10-28 | 2001-05-03 | Merck & Co., Inc. | Novel succinic acid metallo-beta-lactamase inhibitors and their use in treating bacterial infections |
| WO2002022137A1 (en) | 2000-09-12 | 2002-03-21 | Shoichet Brian K | β-LACTAM ANALOGS AND USES THEREFOR |
| DE60111757T2 (de) | 2000-09-14 | 2006-04-27 | Pantherix Ltd. | 3-(Heteroarylacetamido)-2-oxoazetidin-1-sulfonsäure-derivate als antibakterielle Mittel |
| WO2002054931A2 (en) | 2001-01-10 | 2002-07-18 | Bristol Myers Squibb Company P | Alpha-aminoboronic acids prepared by novel synthetic methods |
| DE10118698A1 (de) | 2001-04-17 | 2002-11-07 | Jerini Ag | Verfahren zur Immobilisierung und damit hergestellte Anordnungen von Verbindungen auf einer planaren Oberfläche |
| WO2003057144A2 (en) * | 2001-12-26 | 2003-07-17 | Guilford Pharmaceuticals | Change inhibitors of dipeptidyl peptidase iv |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| JP2003229277A (ja) | 2002-02-04 | 2003-08-15 | Matsushita Electric Ind Co Ltd | 発光素子材料およびそれを用いた発光素子並びに装置 |
| AUPS065102A0 (en) | 2002-02-20 | 2002-03-14 | Unisearch Limited | Fluorous acetalation |
| WO2004024697A1 (ja) | 2002-09-11 | 2004-03-25 | Kureha Chemical Industry Company, Limited | アミン化合物及びその用途 |
| EP2325226A1 (en) | 2002-10-30 | 2011-05-25 | Sumitomo Chemical Company, Limited | Complex aryl copolymer compounds and polymer light emitting devices made by using the same |
| US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| AU2003300358A1 (en) | 2002-12-20 | 2004-07-22 | Migenix Corp. | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
| TW200418791A (en) | 2003-01-23 | 2004-10-01 | Bristol Myers Squibb Co | Pharmaceutical compositions for inhibiting proteasome |
| JP4233365B2 (ja) | 2003-03-25 | 2009-03-04 | 三井化学株式会社 | アザジオール錯体化合物、及び該化合物を用いる光記録媒体 |
| US7842941B2 (en) | 2003-10-06 | 2010-11-30 | Sumitomo Chemical Company, Limited | Aromatic compound |
| MXPA06004043A (es) | 2003-10-10 | 2006-06-28 | Pfizer Prod Inc | 2h-[1,2,4]triazolo[4,3-a]pirazinas sustituidas como inhibidores de la glucogeno sintetasa cinasa 3. |
| DK1689757T3 (en) * | 2003-11-12 | 2014-12-08 | Sino Med Internat Alliance Inc | HETEROCYCLIC DRY ACID COMPOUNDS |
| TW200600494A (en) | 2004-03-08 | 2006-01-01 | Chugai Pharmaceutical Co Ltd | Bisphenyl compounds useful as vitamin d3 receptor agonists |
| US20060019116A1 (en) | 2004-07-22 | 2006-01-26 | Eastman Kodak Company | White electroluminescent device with anthracene derivative host |
| TW200618820A (en) | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
| US20060178357A1 (en) | 2005-02-10 | 2006-08-10 | Buynak John D | Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases |
| AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
| EP1851206B1 (en) | 2005-02-22 | 2012-08-15 | Teva Pharmaceutical Industries, Ltd. | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
| WO2006101779A2 (en) | 2005-03-15 | 2006-09-28 | The University Of Chicago | Non-aqueous electrolytes for lithium ion batteries |
| US7825139B2 (en) * | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| US8901293B2 (en) | 2005-12-07 | 2014-12-02 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| CA2642583C (en) | 2006-02-16 | 2016-08-23 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| AU2007300531A1 (en) | 2006-09-27 | 2008-04-03 | Merck Sharp & Dohme Corp. | Novel inhibitors of beta-lactamase |
| EP2124942B1 (en) | 2007-03-23 | 2016-04-27 | Basilea Pharmaceutica AG | Combination medicaments for treating bacterial infections |
| ES2551916T3 (es) * | 2007-07-23 | 2015-11-24 | The Board Of Trustees Of The University Of Illinois | Sistema para controlar la reactividad de los ácidos borónicos |
| JP5298129B2 (ja) * | 2007-09-06 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | 可溶性グアニレートシクラーゼ活性化因子 |
| GB0719366D0 (en) | 2007-10-03 | 2007-11-14 | Smithkline Beecham Corp | Compounds |
| US20100120715A1 (en) | 2007-11-13 | 2010-05-13 | Burns Christopher J | Beta-lactamase inhibitors |
| EA201000774A1 (ru) | 2007-11-13 | 2010-12-30 | Новартис Интернэшнл Фармасьютикл Лтд. | Ингибиторы бета-лактамазы |
| UA101966C2 (en) | 2008-01-18 | 2013-05-27 | Мерк Шарп Енд Доме Корп. | Beta-lactamase inhibitors |
| US8129398B2 (en) | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US20100256092A1 (en) | 2008-05-12 | 2010-10-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| CN102098918A (zh) | 2008-05-13 | 2011-06-15 | 帕纳德制药公司 | 用于治疗癌症和神经退行性疾病的生物活性化合物 |
| US20120046242A1 (en) | 2008-12-24 | 2012-02-23 | Massachusetts Institute Of Technology | Molecular activators of the wnt/beta-catenin pathway |
| WO2010097675A1 (en) | 2009-02-27 | 2010-09-02 | Dhanuka Laboratories Ltd. | An improved preparation process for cefpodoxime proxetil |
| WO2010104818A1 (en) * | 2009-03-09 | 2010-09-16 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| US20100292185A1 (en) * | 2009-05-12 | 2010-11-18 | Burns Christopher J | Beta-lactamase inhibitors |
| CA2764785C (en) | 2009-06-08 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| RU2012107163A (ru) | 2009-07-28 | 2013-09-10 | Анакор Фармасьютикалз, Инк. | Тризамещенные борсодержащие молекулы |
| WO2011103686A1 (en) | 2010-02-26 | 2011-09-01 | Viswanatha , Sundaramma | CEPHALOSPORIN DERIVATIVES USEFUL AS β-LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF |
| SG184222A1 (en) | 2010-03-31 | 2012-10-30 | Millennium Pharm Inc | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| US20110288063A1 (en) | 2010-05-19 | 2011-11-24 | Naeja Pharmaceutical Inc. | Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors |
| WO2011154953A1 (en) | 2010-06-10 | 2011-12-15 | Technion R&D Foundation Ltd. | Process for the preparation of iodides |
| PT3412676T (pt) | 2010-08-10 | 2020-05-19 | Rempex Pharmaceuticals Inc | Derivados cíclicos de éster de ácido borónico, método para a sua preparação e suas utilizações terapêuticas |
| WO2012058065A1 (en) | 2010-10-26 | 2012-05-03 | Mars Incorporated | Boronates as arginase inhibitors |
| TW201221518A (en) | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| EP2508506A1 (en) | 2011-04-08 | 2012-10-10 | LEK Pharmaceuticals d.d. | Preparation of sitagliptin intermediates |
| CN102320960A (zh) | 2011-08-02 | 2012-01-18 | 安徽东健化工科技有限公司 | 一种6-氟水杨酸的制备方法 |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2013053372A1 (en) | 2011-10-13 | 2013-04-18 | Therabor Pharmaceuticals | Boronic acid inhibitors of beta-lactamases |
| WO2013056163A1 (en) | 2011-10-14 | 2013-04-18 | The Regents Of The University Of California | Beta-lactamase inhibitors |
| HK1206261A1 (en) | 2011-12-22 | 2016-01-08 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| EP2802593A1 (en) | 2012-01-09 | 2014-11-19 | The University of Tromsoe | Therapeutic boron-containing compounds |
| EP2615080A1 (en) | 2012-01-12 | 2013-07-17 | LEK Pharmaceuticals d.d. | Preparation of Optically Pure ß-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof |
| WO2013122888A2 (en) | 2012-02-15 | 2013-08-22 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| ES2878118T3 (es) * | 2012-12-07 | 2021-11-18 | Venatorx Pharmaceuticals Inc | Inhibidores de beta-lactamasa |
| BR112015016001A2 (pt) | 2013-01-04 | 2017-07-11 | Rempex Pharmaceuticals Inc | compostos, composições farmacêuticas e respectivos usos e método para tratar ou prevenir infecção bacteriana |
| KR20150103270A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP6346904B2 (ja) | 2013-01-10 | 2018-06-20 | ベナトルクス ファーマシューティカルズ，インク． | ベータ−ラクタマーゼ阻害剤 |
| EP2970340B1 (en) | 2013-03-14 | 2020-02-12 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| EP2970106B1 (en) | 2013-03-15 | 2018-05-16 | Intrexon Corporation | Boron-containing diacylhydrazines |
| ES2972939T3 (es) | 2014-05-05 | 2024-06-17 | Melinta Therapeutics Inc | Síntesis de sales de boronato |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| BR112016026291A2 (pt) | 2014-05-19 | 2017-08-15 | Rempex Pharmaceuticals Inc | Derivados do ácido borônico e usos terapêuticos dos mesmos |
| CN106687465B (zh) | 2014-06-11 | 2019-04-16 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| EA201692301A1 (ru) | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| WO2016065282A1 (en) | 2014-10-24 | 2016-04-28 | The Regents Of The University Of Michigan | Nasal formulation, nasal kit, and method for enhancing nasal nitric oxide (no) levels |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2016116892A1 (en) | 2015-01-24 | 2016-07-28 | Wockhardt Limited | Antibacterial compositions |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP6945452B2 (ja) | 2015-04-24 | 2021-10-06 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | 細菌感染症の処置方法 |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| AU2017290060B2 (en) | 2016-06-30 | 2021-07-22 | Qpex Biopharma, Inc | Boronic acid derivatives and therapeutic uses thereof |
| AU2017295866A1 (en) | 2016-07-14 | 2019-01-17 | Achaogen, Inc. | Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections |
| US10800778B2 (en) | 2016-09-16 | 2020-10-13 | Entasis Therapeutics Limited | Beta-lactamase inhibitor compounds |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| US11286270B2 (en) | 2017-10-11 | 2022-03-29 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
| WO2019093450A1 (ja) | 2017-11-10 | 2019-05-16 | 塩野義製薬株式会社 | ジアザビシクロオクタン誘導体 |
| EP3781576B1 (en) | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| MA54319A (fr) | 2018-11-29 | 2021-10-06 | Venatorx Pharmaceuticals Inc | Compositions mixtes comprenant un inhibiteur de bêta-lactamase et leurs utilisations |
| CN114340639A (zh) | 2019-06-19 | 2022-04-12 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
| AU2020337449A1 (en) | 2019-08-29 | 2022-03-03 | Arixa Pharmaceuticals, Inc. | Orally administered combinations of beta-lactam antibiotics and avibactam derivatives for treating bacterial infections |
-
2017
- 2017-06-28 AU AU2017290060A patent/AU2017290060B2/en active Active
- 2017-06-28 KR KR1020197003015A patent/KR102403296B1/ko active Active
- 2017-06-28 SG SG11201811549UA patent/SG11201811549UA/en unknown
- 2017-06-28 BR BR112018077015-9A patent/BR112018077015B1/pt active IP Right Grant
- 2017-06-28 MX MX2018015892A patent/MX389349B/es unknown
- 2017-06-28 UA UAA201812390A patent/UA124464C2/uk unknown
- 2017-06-28 WO PCT/US2017/039787 patent/WO2018005662A1/en active IP Right Grant
- 2017-06-28 JP JP2018565257A patent/JP7060245B2/ja active Active
- 2017-06-28 MY MYPI2018002676A patent/MY196909A/en unknown
- 2017-06-28 PL PL17821161T patent/PL3478693T3/pl unknown
- 2017-06-28 US US15/636,424 patent/US10294249B2/en active Active
- 2017-06-28 PT PT17821161T patent/PT3478693T/pt unknown
- 2017-06-28 ES ES17821161T patent/ES2894251T3/es active Active
- 2017-06-28 EP EP17821161.1A patent/EP3478693B1/en active Active
- 2017-06-28 DK DK17821161.1T patent/DK3478693T3/da active
- 2017-06-28 CN CN201780041247.XA patent/CN109415386B/zh active Active
- 2017-06-28 CA CA3026582A patent/CA3026582A1/en active Pending
-
2018
- 2018-12-03 IL IL263450A patent/IL263450B/en unknown
- 2018-12-10 ZA ZA2018/08327A patent/ZA201808327B/en unknown
- 2018-12-19 CL CL2018003681A patent/CL2018003681A1/es unknown
- 2018-12-21 CO CONC2018/0013978A patent/CO2018013978A2/es unknown
- 2018-12-21 PH PH12018502747A patent/PH12018502747A1/en unknown
- 2018-12-25 SA SA518400742A patent/SA518400742B1/ar unknown
-
2019
- 2019-04-08 US US16/378,323 patent/US10570159B2/en active Active
-
2020
- 2020-02-18 US US16/793,965 patent/US11180512B2/en active Active
-
2021
- 2021-11-05 US US17/520,365 patent/US11999759B2/en active Active
-
2024
- 2024-04-17 US US18/638,558 patent/US20250034175A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201808327B (en) | Boronic acid derivatives and therapeutic uses thereof | |
| ZA201608682B (en) | Boronic acid derivatives and therapeutic uses thereof | |
| EP3145936A4 (en) | Boronic acid derivatives and therapeutic uses thereof | |
| EP2941246A4 (en) | BORONIC ACID DERIVATIVES AND THEIR THERAPEUTIC USES | |
| EP2941247A4 (en) | Boronic acid derivatives and therapeutic uses thereof | |
| EP3204360A4 (en) | Therapeutic compounds and uses thereof | |
| GB201403093D0 (en) | Therapeutic compounds and their use | |
| IL255054A0 (en) | Tetrahydronephthyridinyl propionic acid derivatives and their uses | |
| IL273551A (en) | Boronic acid derivatives and their synthesis | |
| ZA201802256B (en) | Compounds and therapeutic uses thereof | |
| IL248934A0 (en) | Topical formulations and their uses | |
| IL255530A (en) | Efflux-pump inhibitors and therapeutic uses thereof | |
| ZA201703976B (en) | Dihydropyrimidine-2-one compounds and medicinal uses thereof | |
| GB201406172D0 (en) | Therapy and pharmaceutical composition | |
| IL265269B (en) | New compounds and their medicinal uses | |
| GB201418809D0 (en) | Therapeutic agents and uses thereof | |
| EP3197470A4 (en) | Cis-gnetin h and trans-gnetin h as therapeutic agents | |
| PL3250181T3 (pl) | Formulacja farmaceutyczna na bazie minoksydylu do stosowania miejscowego i jej zestaw | |
| EP3204003A4 (en) | Selenosugars and therapeutic uses thereof | |
| HK40000809A (en) | Boronic acid derivatives and therapeutic uses thereof | |
| IL251930A0 (en) | Anylhydroxy derivatives, their preparation and medical uses | |
| GB201615560D0 (en) | Novel compounds and therapeutic uses thereof | |
| HK1259593A1 (en) | Compounds and therapeutic uses thereof | |
| AU2014901186A0 (en) | Therapeutic Agents and Uses Thereof | |
| AU2015901219A0 (en) | Therapeutic compounds and uses thereof |