IL260846B2 - Antigen binding proteins that bind pd-l1 - Google Patents

Antigen binding proteins that bind pd-l1

Info

Publication number
IL260846B2
IL260846B2 IL260846A IL26084618A IL260846B2 IL 260846 B2 IL260846 B2 IL 260846B2 IL 260846 A IL260846 A IL 260846A IL 26084618 A IL26084618 A IL 26084618A IL 260846 B2 IL260846 B2 IL 260846B2
Authority
IL
Israel
Prior art keywords
antibody
seq
variable domain
amino acid
fully human
Prior art date
Application number
IL260846A
Other languages
English (en)
Hebrew (he)
Other versions
IL260846A (de
IL260846B (en
Original Assignee
Zhou Heyue
Sorrento Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhou Heyue, Sorrento Therapeutics Inc filed Critical Zhou Heyue
Publication of IL260846A publication Critical patent/IL260846A/en
Publication of IL260846B publication Critical patent/IL260846B/en
Publication of IL260846B2 publication Critical patent/IL260846B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL260846A 2016-01-29 2018-07-29 Antigen binding proteins that bind pd-l1 IL260846B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662288912P 2016-01-29 2016-01-29
PCT/US2017/015429 WO2017132562A1 (en) 2016-01-29 2017-01-27 Antigen binding proteins that bind pd-l1

Publications (3)

Publication Number Publication Date
IL260846A IL260846A (de) 2018-09-20
IL260846B IL260846B (en) 2022-10-01
IL260846B2 true IL260846B2 (en) 2023-02-01

Family

ID=59386438

Family Applications (1)

Application Number Title Priority Date Filing Date
IL260846A IL260846B2 (en) 2016-01-29 2018-07-29 Antigen binding proteins that bind pd-l1

Country Status (17)

Country Link
US (4) US10118963B2 (de)
EP (1) EP3408400B1 (de)
JP (3) JP6883590B2 (de)
KR (1) KR102927822B1 (de)
CN (2) CN109715821B (de)
AU (1) AU2017212717B2 (de)
BR (1) BR112018015480A2 (de)
CA (1) CA3013051A1 (de)
CL (1) CL2018002034A1 (de)
EA (1) EA037855B1 (de)
ES (1) ES2986360T3 (de)
IL (1) IL260846B2 (de)
MX (2) MX2018009228A (de)
PH (1) PH12018501611A1 (de)
SG (1) SG11201806496SA (de)
TW (1) TWI760323B (de)
WO (1) WO2017132562A1 (de)

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CN104736168B (zh) 2012-05-31 2018-09-21 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
CA3013051A1 (en) 2016-01-29 2017-08-03 Heyue Zhou Antigen binding proteins that bind pd-l1
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR20200135447A (ko) * 2018-03-22 2020-12-02 카이레스 아게 길항성 pd-1, pd-l1 및 lag-3 결합 단백질
US11993655B2 (en) 2018-04-09 2024-05-28 Oricell Therapeutics Co., Ltd. Anti-PD-L1 antibody and use thereof
WO2019227490A1 (en) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
EP3818085A4 (de) * 2018-06-01 2022-03-09 Tayu Huaxia Biotech Medical Group Co., Ltd. Zusammensetzungen und deren verwendungen zur behandlung von erkrankungen oder störungen
TW202016150A (zh) * 2018-08-20 2020-05-01 大陸商北京強新生物科技有限公司 新穎癌症免疫治療抗體組合物
EP3893902B1 (de) * 2018-12-11 2024-10-23 Sanford Burnham Prebys Medical Discovery Institute Inhibitoren der pd-l1-aktivität oder -expression zur verwendung in der behandlung von serratiertem kolorektalem krebs
CN113795511B (zh) 2019-01-23 2024-07-23 大有华夏生物医药集团有限公司 抗pd-l1双抗体及其用途
EP3955925B1 (de) * 2019-04-18 2026-02-11 QLSF Biotherapeutics Inc. Humanisierte anti-pd-l1-antikörper
CN113795510A (zh) 2019-08-29 2021-12-14 荣昌生物制药(烟台)股份有限公司 抗pd-l1抗体及其应用
US20230357793A1 (en) * 2020-06-26 2023-11-09 Sorrento Therapeutics, Inc. Oncolytic herpes simplex viruses (hsv) expressing immunomodulatory fusion proteins
JP2023539369A (ja) 2020-09-02 2023-09-13 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 抗体－ナノ粒子複合体、ならびにその作製および使用方法
EP4245865A4 (de) 2020-11-16 2025-07-23 Immuneoncia Therapeutics Inc Biomarker zur vorhersage der therapeutischen reaktion auf ein immuntherapeutisches krebsmittel und verwendung davon
TW202305006A (zh) 2021-05-07 2023-02-01 南韓商益免安協公司 與ｃｄ４７及ｐｄ—ｌ１特異性結合的雙特異性抗體
CN117916264A (zh) 2021-06-09 2024-04-19 索伦托药业有限公司 通过经由淋巴微针递送装置施用抗pd-1或抗pd-l1治疗剂来治疗癌症的方法
CN119866227A (zh) * 2022-09-19 2025-04-22 索诺玛生物治疗公司 用于靶向调节性t细胞以治疗化脓性汗腺炎的瓜氨酸化抗原特异性嵌合抗原受体
JP2026504180A (ja) 2023-01-30 2026-02-03 カイマブ・リミテッド 抗体
WO2025183487A1 (en) * 2024-02-29 2025-09-04 Yuhan Corporation Anti-tigit/anti-pd-l1 bispecific antibody and use thereof
KR20250165706A (ko) 2024-04-13 2025-11-27 주식회사 이뮨온시아 암 치료를 위한 pd-l1 저해제를 이용한 신보조요법
EP4656658A1 (de) 2024-04-13 2025-12-03 Immuneoncia Therapeutics, Inc. Neoadjuvanstherapie mit pd-l1-inhibitor zur behandlung von krebs

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Also Published As

Publication number Publication date
JP2019507183A (ja) 2019-03-14
IL260846A (de) 2018-09-20
CN116333124A (zh) 2023-06-27
EP3408400B1 (de) 2024-06-26
US20240190959A1 (en) 2024-06-13
US11919952B2 (en) 2024-03-05
CN109715821B (zh) 2022-09-06
US20170218066A1 (en) 2017-08-03
CL2018002034A1 (es) 2019-03-15
EA201891709A1 (ru) 2019-01-31
US10118963B2 (en) 2018-11-06
TW201736400A (zh) 2017-10-16
JP2022095910A (ja) 2022-06-28
CN109715821A (zh) 2019-05-03
EA037855B1 (ru) 2021-05-27
WO2017132562A8 (en) 2017-09-08
EP3408400A4 (de) 2019-11-27
KR102927822B1 (ko) 2026-02-13
US20190092861A1 (en) 2019-03-28
PH12018501611A1 (en) 2019-04-08
AU2017212717A1 (en) 2018-09-06
CA3013051A1 (en) 2017-08-03
JP2021102633A (ja) 2021-07-15
MX2022011659A (es) 2022-10-13
IL260846B (en) 2022-10-01
KR20190026642A (ko) 2019-03-13
BR112018015480A2 (pt) 2019-05-21
US20210147539A1 (en) 2021-05-20
JP7140867B2 (ja) 2022-09-21
EP3408400A1 (de) 2018-12-05
EP3408400C0 (de) 2024-06-26
ES2986360T3 (es) 2024-11-11
MX2018009228A (es) 2019-07-08
WO2017132562A1 (en) 2017-08-03
NZ745357A (en) 2025-08-29
JP6883590B2 (ja) 2021-06-09
AU2017212717B2 (en) 2023-11-16
TWI760323B (zh) 2022-04-11
US10919964B2 (en) 2021-02-16
SG11201806496SA (en) 2018-08-30

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