IL250924B - Retinal ganglion cells and their progenitor cells - Google Patents
Retinal ganglion cells and their progenitor cellsInfo
- Publication number
- IL250924B IL250924B IL250924A IL25092417A IL250924B IL 250924 B IL250924 B IL 250924B IL 250924 A IL250924 A IL 250924A IL 25092417 A IL25092417 A IL 25092417A IL 250924 B IL250924 B IL 250924B
- Authority
- IL
- Israel
- Prior art keywords
- progenitors
- ganglion cells
- retinal ganglion
- retinal
- cells
- Prior art date
Links
- 210000003994 retinal ganglion cell Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046165P | 2014-09-05 | 2014-09-05 | |
| PCT/US2015/048741 WO2016037159A1 (en) | 2014-09-05 | 2015-09-05 | Retinal ganglion cells and progenitors thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL250924A0 IL250924A0 (en) | 2017-04-30 |
| IL250924B true IL250924B (en) | 2020-10-29 |
Family
ID=55440432
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL250924A IL250924B (en) | 2014-09-05 | 2017-03-05 | Retinal ganglion cells and their progenitor cells |
| IL277780A IL277780B (en) | 2014-09-05 | 2020-10-04 | Retinal ganglion cells and their progenitor cells |
| IL285258A IL285258A (en) | 2014-09-05 | 2021-08-01 | Retinal ganglion cells and their progenitor cells |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL277780A IL277780B (en) | 2014-09-05 | 2020-10-04 | Retinal ganglion cells and their progenitor cells |
| IL285258A IL285258A (en) | 2014-09-05 | 2021-08-01 | Retinal ganglion cells and their progenitor cells |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170274019A1 (enExample) |
| EP (2) | EP3922717A1 (enExample) |
| JP (2) | JP6778181B2 (enExample) |
| KR (1) | KR20170077117A (enExample) |
| CN (1) | CN107148276A (enExample) |
| AU (2) | AU2015311702A1 (enExample) |
| CA (1) | CA2960211A1 (enExample) |
| ES (1) | ES2883600T3 (enExample) |
| IL (3) | IL250924B (enExample) |
| PL (1) | PL3189135T3 (enExample) |
| PT (1) | PT3189135T (enExample) |
| SG (3) | SG11201701709YA (enExample) |
| WO (1) | WO2016037159A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL287381B2 (en) * | 2011-11-14 | 2024-04-01 | Astellas Inst For Regenerative Medicine | Pharmaceutical preparations of human rpe cells and uses thereof |
| EP3869195B1 (en) | 2015-03-23 | 2024-03-20 | Astellas Institute for Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| KR102411018B1 (ko) | 2015-08-18 | 2022-06-20 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 임상 제제 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2019078781A1 (en) | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| WO2019152812A1 (en) * | 2018-02-02 | 2019-08-08 | University Of Maryland, Baltimore | Methods of treating optic nerve diseases using neural progenitor cell growth factors |
| US11621058B2 (en) * | 2018-02-08 | 2023-04-04 | Ohio State Innovation Foundation | Synthetic IHC-stained digital sides generated using artificial neural networks |
| DK3810758T3 (da) * | 2018-06-20 | 2023-10-16 | Biolamina Ab | Metoder og sammensætninger til fremstilling af retina pigment epitelceller |
| KR102196069B1 (ko) | 2019-04-17 | 2020-12-29 | 경북대학교 산학협력단 | 망막신경절세포의 분리방법 및 그에 의해 분리된 세포의 용도 |
| CN112251408B (zh) * | 2020-09-14 | 2022-04-12 | 郑州大学 | 视网膜神经节细胞的制备方法 |
| CN114917367A (zh) * | 2021-06-02 | 2022-08-19 | 中国科学院动物研究所 | Lhx2在促进中枢系统神经元的损伤修复再生中的应用 |
| CN115404219B (zh) * | 2022-09-09 | 2023-10-27 | 中国医学科学院医学生物学研究所 | 一种树鼩视网膜神经节细胞的分离培养方法 |
| CN117821382A (zh) * | 2023-12-29 | 2024-04-05 | 广州赛莱拉干细胞科技股份有限公司 | 一种毛囊干细胞无血清培养基和培养方法 |
| CN118028232A (zh) * | 2024-01-24 | 2024-05-14 | 中山大学中山眼科中心 | 从视网膜类器官纯化新型神经节样细胞方法及应用 |
| WO2025264696A2 (en) * | 2024-06-17 | 2025-12-26 | The Regents Of The University Of Colorado, A Body Corporate | Restorative cell therapy for eye diseases and vision loss |
| WO2026019376A1 (en) * | 2024-07-18 | 2026-01-22 | National University Of Singapore | Reprograming of pluripotent stem cells into ganglion progenitors using a neuronal differentiation transcription factor for treatment of ocular disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2697363A1 (en) * | 2007-08-23 | 2009-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptogenesis |
| KR101995016B1 (ko) * | 2007-12-04 | 2019-06-28 | 프로테오바이오엑티브스 피티와이 엘티디 | 전구 세포의 보호 및 그의 분화 조절 |
| EP3553170B1 (en) * | 2009-08-24 | 2024-02-14 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
| KR101712556B1 (ko) | 2014-08-27 | 2017-03-08 | 서울대학교산학협력단 | 줄기세포를 망막신경절세포로 분화시키는 방법 |
-
2015
- 2015-09-05 PL PL15838263T patent/PL3189135T3/pl unknown
- 2015-09-05 SG SG11201701709YA patent/SG11201701709YA/en unknown
- 2015-09-05 JP JP2017512937A patent/JP6778181B2/ja not_active Expired - Fee Related
- 2015-09-05 US US15/508,533 patent/US20170274019A1/en active Pending
- 2015-09-05 AU AU2015311702A patent/AU2015311702A1/en not_active Abandoned
- 2015-09-05 EP EP21168050.9A patent/EP3922717A1/en not_active Withdrawn
- 2015-09-05 KR KR1020177008900A patent/KR20170077117A/ko not_active Ceased
- 2015-09-05 PT PT158382630T patent/PT3189135T/pt unknown
- 2015-09-05 ES ES15838263T patent/ES2883600T3/es active Active
- 2015-09-05 SG SG10201901559SA patent/SG10201901559SA/en unknown
- 2015-09-05 WO PCT/US2015/048741 patent/WO2016037159A1/en not_active Ceased
- 2015-09-05 CA CA2960211A patent/CA2960211A1/en not_active Abandoned
- 2015-09-05 CN CN201580056489.7A patent/CN107148276A/zh active Pending
- 2015-09-05 SG SG10201912296RA patent/SG10201912296RA/en unknown
- 2015-09-05 EP EP15838263.0A patent/EP3189135B1/en active Active
-
2017
- 2017-03-05 IL IL250924A patent/IL250924B/en active IP Right Grant
-
2020
- 2020-07-20 JP JP2020124010A patent/JP7263293B2/ja active Active
- 2020-10-04 IL IL277780A patent/IL277780B/en unknown
-
2021
- 2021-08-01 IL IL285258A patent/IL285258A/en unknown
- 2021-09-28 AU AU2021240145A patent/AU2021240145A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6778181B2 (ja) | 2020-10-28 |
| AU2015311702A1 (en) | 2017-04-06 |
| PL3189135T3 (pl) | 2021-12-20 |
| JP2017532954A (ja) | 2017-11-09 |
| IL285258A (en) | 2021-09-30 |
| EP3189135B1 (en) | 2021-06-02 |
| ES2883600T3 (es) | 2021-12-09 |
| IL277780A (en) | 2020-11-30 |
| IL250924A0 (en) | 2017-04-30 |
| JP2020185004A (ja) | 2020-11-19 |
| AU2021240145A1 (en) | 2021-10-28 |
| IL277780B (en) | 2021-08-31 |
| WO2016037159A1 (en) | 2016-03-10 |
| EP3922717A1 (en) | 2021-12-15 |
| SG11201701709YA (en) | 2017-04-27 |
| CN107148276A (zh) | 2017-09-08 |
| SG10201912296RA (en) | 2020-02-27 |
| KR20170077117A (ko) | 2017-07-05 |
| PT3189135T (pt) | 2021-08-19 |
| SG10201901559SA (en) | 2019-03-28 |
| CA2960211A1 (en) | 2016-03-10 |
| EP3189135A4 (en) | 2018-04-25 |
| EP3189135A1 (en) | 2017-07-12 |
| US20170274019A1 (en) | 2017-09-28 |
| JP7263293B2 (ja) | 2023-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |