JP6778181B2 - 網膜神経節細胞およびその前駆体 - Google Patents

網膜神経節細胞およびその前駆体 Download PDF

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JP6778181B2
JP6778181B2 JP2017512937A JP2017512937A JP6778181B2 JP 6778181 B2 JP6778181 B2 JP 6778181B2 JP 2017512937 A JP2017512937 A JP 2017512937A JP 2017512937 A JP2017512937 A JP 2017512937A JP 6778181 B2 JP6778181 B2 JP 6778181B2
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progenitor cells
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JP2017532954A5 (enExample
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ワン，ウェイ
リウ，シー−ジャン
ランツァ，ロバート，ピー．
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アステラス インスティテュート フォー リジェネレイティブ メディシン
アステラス インスティテュート フォー リジェネレイティブ メディシン
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017512937A 2014-09-05 2015-09-05 網膜神経節細胞およびその前駆体 Active JP6778181B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462046165P 2014-09-05 2014-09-05
US62/046,165 2014-09-05
PCT/US2015/048741 WO2016037159A1 (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof

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JP2020124010A Division JP7263293B2 (ja) 2014-09-05 2020-07-20 網膜神経節細胞およびその前駆体

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JP2017532954A JP2017532954A (ja) 2017-11-09
JP2017532954A5 JP2017532954A5 (enExample) 2018-09-27
JP6778181B2 true JP6778181B2 (ja) 2020-10-28

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JP2020124010A Active JP7263293B2 (ja) 2014-09-05 2020-07-20 網膜神経節細胞およびその前駆体

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US (1) US20170274019A1 (enExample)
EP (2) EP3189135B1 (enExample)
JP (2) JP6778181B2 (enExample)
KR (1) KR20170077117A (enExample)
CN (1) CN107148276A (enExample)
AU (2) AU2015311702A1 (enExample)
CA (1) CA2960211A1 (enExample)
ES (1) ES2883600T3 (enExample)
IL (3) IL250924B (enExample)
PL (1) PL3189135T3 (enExample)
PT (1) PT3189135T (enExample)
SG (3) SG10201912296RA (enExample)
WO (1) WO2016037159A1 (enExample)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
CA2855941A1 (en) * 2011-11-14 2013-05-23 Advanced Cell Technology, Inc. Pharmaceutical preparations of human rpe cells and uses thereof
EP4343331A3 (en) 2015-03-23 2024-06-19 Astellas Institute for Regenerative Medicine Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors
AU2016308818B2 (en) 2015-08-18 2022-04-21 Astellas Institute For Regenerative Medicine Clinical formulations
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
WO2019078781A1 (en) 2017-10-17 2019-04-25 National University Of Singapore SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS
WO2019152812A1 (en) * 2018-02-02 2019-08-08 University Of Maryland, Baltimore Methods of treating optic nerve diseases using neural progenitor cell growth factors
US11621058B2 (en) 2018-02-08 2023-04-04 Ohio State Innovation Foundation Synthetic IHC-stained digital sides generated using artificial neural networks
US20210261918A1 (en) * 2018-06-20 2021-08-26 Biolamina Ab Methods for producing retinal pigment epithelium cells
KR102196069B1 (ko) 2019-04-17 2020-12-29 경북대학교 산학협력단 망막신경절세포의 분리방법 및 그에 의해 분리된 세포의 용도
CN112251408B (zh) * 2020-09-14 2022-04-12 郑州大学 视网膜神经节细胞的制备方法
CN114917367A (zh) * 2021-06-02 2022-08-19 中国科学院动物研究所 Lhx2在促进中枢系统神经元的损伤修复再生中的应用
CN115404219B (zh) * 2022-09-09 2023-10-27 中国医学科学院医学生物学研究所 一种树鼩视网膜神经节细胞的分离培养方法
CN117821382A (zh) * 2023-12-29 2024-04-05 广州赛莱拉干细胞科技股份有限公司 一种毛囊干细胞无血清培养基和培养方法

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Publication number Priority date Publication date Assignee Title
CA2697363A1 (en) * 2007-08-23 2009-03-05 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptogenesis
KR101828421B1 (ko) * 2007-12-04 2018-02-12 프로테오바이오엑티브스 피티와이 엘티디 전구 세포의 보호 및 그의 분화 조절
CA3066806C (en) * 2009-08-24 2023-03-07 David M. Gamm Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
EP2486126B1 (en) * 2009-10-06 2017-12-06 SNU R & DB Foundation Method for differentiation into retinal cells from stem cells
KR101712556B1 (ko) * 2014-08-27 2017-03-08 서울대학교산학협력단 줄기세포를 망막신경절세포로 분화시키는 방법

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SG10201912296RA (en) 2020-02-27
SG10201901559SA (en) 2019-03-28
IL277780A (en) 2020-11-30
EP3922717A1 (en) 2021-12-15
PT3189135T (pt) 2021-08-19
JP2020185004A (ja) 2020-11-19
EP3189135B1 (en) 2021-06-02
KR20170077117A (ko) 2017-07-05
PL3189135T3 (pl) 2021-12-20
SG11201701709YA (en) 2017-04-27
JP7263293B2 (ja) 2023-04-24
IL250924A0 (en) 2017-04-30
WO2016037159A1 (en) 2016-03-10
AU2021240145A1 (en) 2021-10-28
IL285258A (en) 2021-09-30
ES2883600T3 (es) 2021-12-09
IL250924B (en) 2020-10-29
CA2960211A1 (en) 2016-03-10
EP3189135A1 (en) 2017-07-12
EP3189135A4 (en) 2018-04-25
AU2015311702A1 (en) 2017-04-06
JP2017532954A (ja) 2017-11-09
IL277780B (en) 2021-08-31
CN107148276A (zh) 2017-09-08
US20170274019A1 (en) 2017-09-28

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