CN107148276A - 视网膜神经节细胞及其祖细胞 - Google Patents

视网膜神经节细胞及其祖细胞 Download PDF

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Publication number
CN107148276A
CN107148276A CN201580056489.7A CN201580056489A CN107148276A CN 107148276 A CN107148276 A CN 107148276A CN 201580056489 A CN201580056489 A CN 201580056489A CN 107148276 A CN107148276 A CN 107148276A
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cells
progenitor cells
preparation
brn3a
progenitor
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Chinese (zh)
Inventor
汪维
卢世江
R·P·兰扎
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Astellas Institute for Regenerative Medicine
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Ocata Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201580056489.7A 2014-09-05 2015-09-05 视网膜神经节细胞及其祖细胞 Pending CN107148276A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462046165P 2014-09-05 2014-09-05
US62/046,165 2014-09-05
PCT/US2015/048741 WO2016037159A1 (en) 2014-09-05 2015-09-05 Retinal ganglion cells and progenitors thereof

Publications (1)

Publication Number Publication Date
CN107148276A true CN107148276A (zh) 2017-09-08

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CN201580056489.7A Pending CN107148276A (zh) 2014-09-05 2015-09-05 视网膜神经节细胞及其祖细胞

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US (1) US20170274019A1 (enExample)
EP (2) EP3922717A1 (enExample)
JP (2) JP6778181B2 (enExample)
KR (1) KR20170077117A (enExample)
CN (1) CN107148276A (enExample)
AU (2) AU2015311702A1 (enExample)
CA (1) CA2960211A1 (enExample)
ES (1) ES2883600T3 (enExample)
IL (3) IL250924B (enExample)
PL (1) PL3189135T3 (enExample)
PT (1) PT3189135T (enExample)
SG (3) SG11201701709YA (enExample)
WO (1) WO2016037159A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111712564A (zh) * 2017-10-17 2020-09-25 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
CN112251408A (zh) * 2020-09-14 2021-01-22 郑州大学 视网膜神经节细胞的制备方法
CN113786417A (zh) * 2011-11-14 2021-12-14 安斯泰来再生医药协会 人rpe细胞的药物制剂及其用途
CN114917367A (zh) * 2021-06-02 2022-08-19 中国科学院动物研究所 Lhx2在促进中枢系统神经元的损伤修复再生中的应用
CN118028232A (zh) * 2024-01-24 2024-05-14 中山大学中山眼科中心 从视网膜类器官纯化新型神经节样细胞方法及应用
WO2025139630A1 (zh) * 2023-12-29 2025-07-03 广州赛莱拉干细胞科技股份有限公司 一种毛囊干细胞无血清培养基和培养方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3869195B1 (en) 2015-03-23 2024-03-20 Astellas Institute for Regenerative Medicine Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors
KR102411018B1 (ko) 2015-08-18 2022-06-20 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
WO2019152812A1 (en) * 2018-02-02 2019-08-08 University Of Maryland, Baltimore Methods of treating optic nerve diseases using neural progenitor cell growth factors
US11621058B2 (en) * 2018-02-08 2023-04-04 Ohio State Innovation Foundation Synthetic IHC-stained digital sides generated using artificial neural networks
DK3810758T3 (da) * 2018-06-20 2023-10-16 Biolamina Ab Metoder og sammensætninger til fremstilling af retina pigment epitelceller
KR102196069B1 (ko) 2019-04-17 2020-12-29 경북대학교 산학협력단 망막신경절세포의 분리방법 및 그에 의해 분리된 세포의 용도
CN115404219B (zh) * 2022-09-09 2023-10-27 中国医学科学院医学生物学研究所 一种树鼩视网膜神经节细胞的分离培养方法
WO2025264696A2 (en) * 2024-06-17 2025-12-26 The Regents Of The University Of Colorado, A Body Corporate Restorative cell therapy for eye diseases and vision loss
WO2026019376A1 (en) * 2024-07-18 2026-01-22 National University Of Singapore Reprograming of pluripotent stem cells into ganglion progenitors using a neuronal differentiation transcription factor for treatment of ocular disorders

Citations (3)

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CN101939417A (zh) * 2007-12-04 2011-01-05 蛋白生物动力私人有限公司 祖细胞的保护和它们的分化的调节
CN102316888A (zh) * 2007-08-23 2012-01-11 利兰斯坦福青年大学托管委员会 突触发生的调控
CN102712900A (zh) * 2009-10-06 2012-10-03 首尔大学校产学协力团 干细胞分化成为视网膜细胞的方法

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EP3553170B1 (en) * 2009-08-24 2024-02-14 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
KR101712556B1 (ko) 2014-08-27 2017-03-08 서울대학교산학협력단 줄기세포를 망막신경절세포로 분화시키는 방법

Patent Citations (3)

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CN102316888A (zh) * 2007-08-23 2012-01-11 利兰斯坦福青年大学托管委员会 突触发生的调控
CN101939417A (zh) * 2007-12-04 2011-01-05 蛋白生物动力私人有限公司 祖细胞的保护和它们的分化的调节
CN102712900A (zh) * 2009-10-06 2012-10-03 首尔大学校产学协力团 干细胞分化成为视网膜细胞的方法

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CATHERINE B. KESSLER ET AL.: "Increased Notch 1 Expression and Attenuated Stimulatory G Protein Coupling to Adenylyl Cyclase in Osteonectin-Null Osteoblasts", 《ENDOCRINOLOGY》 *
HAMIDREZA RIAZIFAR ET AL.: "Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells", 《STEM CELLS TRANSLATIONAL MEDICINE》 *
JING YAO ET AL.: "Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells", 《MOLECULAR VISION》 *
KATHERINE P. GILL ET AL.: "Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells", 《TVST》 *
XIN-MEI ZHANG ET AL.: "Immunopanning purification and long-term culture of human", 《MOLECULAR VISION》 *
XIUQIAN MU ET AL.: "A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate", 《DEVELOPMENTAL BIOLOGY》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113786417A (zh) * 2011-11-14 2021-12-14 安斯泰来再生医药协会 人rpe细胞的药物制剂及其用途
CN111712564A (zh) * 2017-10-17 2020-09-25 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
CN111712564B (zh) * 2017-10-17 2023-10-20 新加坡国立大学 用于产生视网膜祖细胞的系统和方法
US12221624B2 (en) 2017-10-17 2025-02-11 National University Of Singapore Systems and methods for producing retinal progenitors
CN112251408A (zh) * 2020-09-14 2021-01-22 郑州大学 视网膜神经节细胞的制备方法
WO2022052338A1 (zh) * 2020-09-14 2022-03-17 郑州大学 视网膜神经节细胞的制备方法
CN114917367A (zh) * 2021-06-02 2022-08-19 中国科学院动物研究所 Lhx2在促进中枢系统神经元的损伤修复再生中的应用
WO2025139630A1 (zh) * 2023-12-29 2025-07-03 广州赛莱拉干细胞科技股份有限公司 一种毛囊干细胞无血清培养基和培养方法
CN118028232A (zh) * 2024-01-24 2024-05-14 中山大学中山眼科中心 从视网膜类器官纯化新型神经节样细胞方法及应用

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JP6778181B2 (ja) 2020-10-28
AU2015311702A1 (en) 2017-04-06
PL3189135T3 (pl) 2021-12-20
JP2017532954A (ja) 2017-11-09
IL285258A (en) 2021-09-30
EP3189135B1 (en) 2021-06-02
ES2883600T3 (es) 2021-12-09
IL250924B (en) 2020-10-29
IL277780A (en) 2020-11-30
IL250924A0 (en) 2017-04-30
JP2020185004A (ja) 2020-11-19
AU2021240145A1 (en) 2021-10-28
IL277780B (en) 2021-08-31
WO2016037159A1 (en) 2016-03-10
EP3922717A1 (en) 2021-12-15
SG11201701709YA (en) 2017-04-27
SG10201912296RA (en) 2020-02-27
KR20170077117A (ko) 2017-07-05
PT3189135T (pt) 2021-08-19
SG10201901559SA (en) 2019-03-28
CA2960211A1 (en) 2016-03-10
EP3189135A4 (en) 2018-04-25
EP3189135A1 (en) 2017-07-12
US20170274019A1 (en) 2017-09-28
JP7263293B2 (ja) 2023-04-24

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