IL248376B - Recombinant host cell engineered for overexpression of accessory proteins - Google Patents

Recombinant host cell engineered for overexpression of accessory proteins

Info

Publication number
IL248376B
IL248376B IL248376A IL24837616A IL248376B IL 248376 B IL248376 B IL 248376B IL 248376 A IL248376 A IL 248376A IL 24837616 A IL24837616 A IL 24837616A IL 248376 B IL248376 B IL 248376B
Authority
IL
Israel
Prior art keywords
host cell
recombinant host
cell engineered
helper proteins
overexpress
Prior art date
Application number
IL248376A
Other languages
English (en)
Hebrew (he)
Other versions
IL248376A0 (en
Original Assignee
Boehringer Ingelheim Rcv Gmbh
Sandoz Ag
Validogen Gmbh
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Rcv Gmbh, Sandoz Ag, Validogen Gmbh, Lonza Ag filed Critical Boehringer Ingelheim Rcv Gmbh
Publication of IL248376A0 publication Critical patent/IL248376A0/en
Publication of IL248376B publication Critical patent/IL248376B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL248376A 2014-04-17 2016-10-18 Recombinant host cell engineered for overexpression of accessory proteins IL248376B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14165186 2014-04-17
PCT/EP2015/058242 WO2015158808A2 (en) 2014-04-17 2015-04-16 Recombinant host cell engineered to overexpress helper proteins

Publications (2)

Publication Number Publication Date
IL248376A0 IL248376A0 (en) 2016-11-30
IL248376B true IL248376B (en) 2021-04-29

Family

ID=50513080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL248376A IL248376B (en) 2014-04-17 2016-10-18 Recombinant host cell engineered for overexpression of accessory proteins

Country Status (11)

Country Link
US (1) US10865416B2 (https=)
EP (2) EP4311857A3 (https=)
JP (2) JP2017511148A (https=)
KR (1) KR102373954B1 (https=)
CN (1) CN106661541B (https=)
AU (1) AU2015248815B2 (https=)
BR (1) BR112016023304A2 (https=)
CA (1) CA2948369C (https=)
IL (1) IL248376B (https=)
SG (2) SG11201608084TA (https=)
WO (1) WO2015158808A2 (https=)

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EP3132039B1 (en) 2014-04-17 2019-07-24 Boehringer Ingelheim RCV GmbH & Co KG Recombinant host cell for expressing proteins of interest
JP2018501814A (ja) 2014-11-11 2018-01-25 クララ フーズ カンパニー 卵白タンパク質産生のための方法および組成物
SG11201908079SA (en) * 2017-03-29 2019-10-30 Boehringer Ingelheim Rcv Gmbh Recombinant host cell with altered membrane lipid composition
CN109722445A (zh) * 2017-10-27 2019-05-07 成都必高生物科技有限公司 提升溶菌酶产量及活性的方法
WO2019097049A1 (en) * 2017-11-20 2019-05-23 Axxence Holding B.V. Production of a flavour compound in a host cell
CN112166181B (zh) 2018-05-17 2024-03-08 保尔特纺织品公司 用于改善重组蛋白分泌的sec经修饰菌株
US20210269811A1 (en) * 2018-06-27 2021-09-02 Boehringer Ingelheim Rcv Gmbh & Co Kg Means and methods for increased protein expression by use of transcription factors
EP3824083A4 (en) * 2018-09-24 2022-01-05 Orta Dogu Teknik Universitesi Design of alcohol dehydrogenase 2 (adh2) promoter variants by promoter engineering
CN109439640B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDSB及其基因和应用
CN109439639B (zh) * 2018-10-09 2021-07-20 天津科技大学 伏马毒素降解酶FumDPS及其基因和应用
CN111378585B (zh) 2018-12-28 2023-06-16 丰益(上海)生物技术研发中心有限公司 用于表达外源基因的毕赤酵母突变株
DK3874047T4 (da) * 2019-01-11 2025-02-03 Lonza Ag Karbonkilde-reguleret proteinproduktion i en rekombinant værtscelle
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
BR112022000545A2 (pt) 2019-07-11 2022-04-05 Clara Foods Co Composições de proteína e produtos de consumo destas
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN115362260A (zh) * 2020-02-04 2022-11-18 克莱拉食品公司 用于高产重组微生物的系统和方法及其用途
CN111349177B (zh) * 2020-03-13 2022-04-22 西北农林科技大学 一种融合抗菌肽cat的制备方法和应用
CN111607575B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶phta、制备方法和应用
CN111549007B (zh) * 2020-04-07 2022-10-04 天津科技大学 一种转氨酶tsta、制备方法和应用
CN113088533B (zh) * 2021-04-15 2023-03-24 华中科技大学 一种高效表达藤壶粘胶蛋白的酵母工程菌及其制备方法
CN113801801B (zh) * 2021-10-08 2023-03-07 枣庄市杰诺生物酶有限公司 一株高效生产碱性果胶酶的重组菌及其应用
CN118147180A (zh) * 2024-05-09 2024-06-07 芝诺(苏州)生物科技有限公司 一种代谢工程改造毕赤酵母合成人乳铁蛋白的方法

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EP3132039B1 (en) * 2014-04-17 2019-07-24 Boehringer Ingelheim RCV GmbH & Co KG Recombinant host cell for expressing proteins of interest

Also Published As

Publication number Publication date
JP7062633B2 (ja) 2022-05-06
AU2015248815B2 (en) 2021-07-08
CN106661541A (zh) 2017-05-10
EP4311857A3 (en) 2024-07-31
AU2015248815A1 (en) 2016-11-03
EP3132028A2 (en) 2017-02-22
KR102373954B1 (ko) 2022-03-14
KR20170002453A (ko) 2017-01-06
SG11201608084TA (en) 2016-10-28
SG10201809146QA (en) 2018-11-29
JP2017511148A (ja) 2017-04-20
US20170029827A1 (en) 2017-02-02
CA2948369A1 (en) 2015-10-22
IL248376A0 (en) 2016-11-30
CA2948369C (en) 2023-09-26
EP4311857A2 (en) 2024-01-31
EP3132028B1 (en) 2023-10-25
JP2020072696A (ja) 2020-05-14
CN106661541B (zh) 2021-09-03
WO2015158808A3 (en) 2016-01-28
WO2015158808A2 (en) 2015-10-22
US10865416B2 (en) 2020-12-15
BR112016023304A2 (pt) 2017-10-17

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