IL241930B - Isolated naive pluripotent stem cells and methods of generating same - Google Patents
Isolated naive pluripotent stem cells and methods of generating sameInfo
- Publication number
- IL241930B IL241930B IL241930A IL24193015A IL241930B IL 241930 B IL241930 B IL 241930B IL 241930 A IL241930 A IL 241930A IL 24193015 A IL24193015 A IL 24193015A IL 241930 B IL241930 B IL 241930B
- Authority
- IL
- Israel
- Prior art keywords
- pluripotent
- creation
- methods
- stem cells
- naïve stem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361814920P | 2013-04-23 | 2013-04-23 | |
| US201361878769P | 2013-09-17 | 2013-09-17 | |
| US201461932935P | 2014-01-29 | 2014-01-29 | |
| PCT/IB2014/060954 WO2014174470A1 (en) | 2013-04-23 | 2014-04-23 | Isolated naive pluripotent stem cells and methods of generating same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL241930B true IL241930B (en) | 2020-06-30 |
Family
ID=50842281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL241930A IL241930B (en) | 2013-04-23 | 2015-10-06 | Isolated naive pluripotent stem cells and methods of generating same |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10920192B2 (enExample) |
| EP (1) | EP2989199B1 (enExample) |
| JP (1) | JP2016521971A (enExample) |
| CN (1) | CN105531365A (enExample) |
| ES (1) | ES2831424T3 (enExample) |
| IL (1) | IL241930B (enExample) |
| WO (1) | WO2014174470A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011503232A (ja) | 2007-11-20 | 2011-01-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 免疫応答の調節 |
| WO2014174470A1 (en) | 2013-04-23 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
| CN105980568B (zh) | 2013-12-11 | 2019-12-03 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| EP3194572B1 (en) * | 2014-07-30 | 2023-10-25 | Yeda Research and Development Co. Ltd. | Media for culturing pluripotent stem cells |
| EP3183336B2 (en) * | 2014-08-22 | 2025-07-09 | Cambridge Enterprise Limited | Resetting pluripotent stem cells |
| CN105441384B (zh) * | 2014-09-26 | 2021-01-05 | 北京大学 | 一种制备动物和人类原始多潜能干细胞的方法,试剂盒及用途 |
| PL3207124T3 (pl) | 2014-10-15 | 2019-11-29 | Regeneron Pharma | Sposoby i kompozycje do wytwarzania lub utrzymywania komórek pluripotencjalnych |
| EP3221446B1 (en) | 2014-11-17 | 2024-08-21 | Genome Research Limited | In vitro production of expanded potential stem cells |
| EP3274053A4 (en) | 2015-03-23 | 2018-12-05 | The Brigham and Women's Hospital, Inc. | Tolerogenic nanoparticles for treating diabetes mellitus |
| US10497127B2 (en) * | 2015-04-23 | 2019-12-03 | Koninklijke Philips N.V. | Model-based segmentation of an anatomical structure |
| EP3292198A4 (en) * | 2015-05-05 | 2018-10-17 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Reversion of primed pluripotent stem cells to naive pluripotent stem cells |
| WO2017002888A1 (ja) * | 2015-06-29 | 2017-01-05 | 国立大学法人京都大学 | 多能性幹細胞から生殖細胞への分化誘導方法 |
| CA2994192C (en) * | 2015-08-13 | 2020-06-16 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced extended pluripotent stem cells, methods of making and using |
| WO2017144695A1 (en) | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| JPWO2017170849A1 (ja) * | 2016-03-30 | 2019-05-16 | 協和発酵バイオ株式会社 | ナイーブ型多能性幹細胞培養用培地および多能性幹細胞の培養方法 |
| CN106244522A (zh) * | 2016-08-12 | 2016-12-21 | 浙江译美生物科技有限公司 | 一种干细胞培养体系及其培养方法 |
| EP3500276A4 (en) * | 2016-08-19 | 2020-01-15 | Memorial Sloan-Kettering Cancer Center | METHOD FOR DIFFERENTIATING STEM CELLS IN ENDODERM |
| GB201615343D0 (en) * | 2016-09-09 | 2016-10-26 | Zernicka-Goetz Magdalena And Harrison Sarah E M | Methods |
| ES3009605T3 (en) * | 2016-10-05 | 2025-03-27 | Fujifilm Cellular Dynamics Inc | Generating mature lineages from induced pluripotent stem cells with mecp2 disruption |
| CN110099921A (zh) * | 2016-12-23 | 2019-08-06 | 干细胞生物科技公司 | 体干细胞用于降低il-6水平的用途 |
| AU2018209127B2 (en) * | 2017-01-23 | 2021-10-21 | Stemcell Technologies Canada Inc. | Media and methods for enhancing the survival and proliferation of stem cells |
| US10783627B2 (en) * | 2017-03-03 | 2020-09-22 | Case Western Reserve University | Predicting cancer recurrence using local co-occurrence of cell morphology (LoCoM) |
| WO2018209232A1 (en) * | 2017-05-12 | 2018-11-15 | Regents Of The University Of Minnesota | Methods of preparing naive human pluripotent stem cells |
| ES2903187T3 (es) * | 2017-06-13 | 2022-03-31 | Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin | Procedimientos de producción de organoides neuronales de bioingeniería (BENO) y sus usos |
| CN107523540B (zh) * | 2017-06-27 | 2021-02-12 | 香港大学深圳医院 | 一种建立家族遗传性卵巢早衰来源的诱导全能干细胞向原始生殖嵴细胞诱导分化的方法 |
| CA3083253A1 (en) | 2017-11-30 | 2019-06-06 | Kyoto University | Method for culture of cells |
| CN108707629A (zh) * | 2018-05-28 | 2018-10-26 | 上海海洋大学 | 斑马鱼notch1b基因突变体的制备方法 |
| KR102131921B1 (ko) * | 2018-10-30 | 2020-07-08 | 차의과학대학교 산학협력단 | 줄기 세포의 신경전구세포로의 분화용 조성물, 키트, 및 이를 이용한 방법 |
| CN109355300B (zh) * | 2018-11-26 | 2022-01-28 | 成都中医药大学 | 黄连sdir转录因子在提高植物抗旱中的应用 |
| WO2020152686A1 (en) * | 2019-01-23 | 2020-07-30 | Yeda Research And Development Co. Ltd. | Culture media for pluripotent stem cells |
| WO2021015228A1 (ja) * | 2019-07-25 | 2021-01-28 | 富士フイルム株式会社 | 特定の分化細胞の製造方法 |
| WO2021020267A1 (ja) * | 2019-07-26 | 2021-02-04 | 富士フイルム株式会社 | ナイーブ型多能性幹細胞の増殖能亢進用培地および多能性幹細胞の製造方法 |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| CN110646335A (zh) * | 2019-09-29 | 2020-01-03 | 广东工业大学 | 一种封闭液及其应用 |
| CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
| CN115003795B (zh) * | 2019-11-14 | 2025-03-11 | 岛崎猛夫 | 细胞的重编程方法 |
| WO2021193596A1 (ja) * | 2020-03-24 | 2021-09-30 | 学校法人自治医科大学 | 一時処理培地、処理キット、胚発生停止抑制剤、胚発生停止抑制方法、発生工学産物作製方法、移植方法、治療方法、及び発生工学産物 |
| CN111487399B (zh) * | 2020-03-26 | 2021-09-17 | 湖南师范大学 | 一种蛋白分子标记在鱼类生殖细胞发育研究中的应用 |
| TWI761837B (zh) * | 2020-05-20 | 2022-04-21 | 國立中央大學 | 通用人類誘導多能性幹細胞及其生成方法 |
| WO2021243252A1 (en) * | 2020-05-29 | 2021-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Generation of primordial germ cells and methods of using the same |
| US20210395698A1 (en) * | 2020-06-22 | 2021-12-23 | Life Technologies Corporation | Methods and compositions for cultivating pluripotent cell suspensions |
| WO2021262619A1 (en) * | 2020-06-24 | 2021-12-30 | Zhen Ma | Generation of perinatal-like mesenchymal stem cells from human induced pluripotent stem cells |
| CN111650327B (zh) * | 2020-07-16 | 2023-06-02 | 扬州大学 | 一种基于非标定量蛋白质组学技术寻找如皋黄鸡不同细胞或组织间差异表达蛋白的方法 |
| CN112048467A (zh) * | 2020-09-11 | 2020-12-08 | 江苏集萃药康生物科技有限公司 | Ksom-aa培养液在体外培养nod背景鼠胚胎中的应用 |
| WO2022099498A1 (en) * | 2020-11-11 | 2022-05-19 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Media and methods for establishing and maintaining early embryo-like cells |
| JPWO2022114188A1 (enExample) * | 2020-11-30 | 2022-06-02 | ||
| CN112831461B (zh) * | 2021-02-26 | 2023-08-08 | 澳门大学 | 一种诱导干细胞分化成中胚层谱系或滋养细胞谱系的方法及药物 |
| US12467917B2 (en) | 2021-03-16 | 2025-11-11 | California Institute Of Technology | Reconstructing human early embryogenesis in vitro with pluripotent stem cells |
| CA3237860A1 (en) * | 2021-11-12 | 2023-05-19 | Remi LABRECQUE | Derivation of naive bovine embryonic stem cells |
| CN114164258B (zh) * | 2021-12-22 | 2022-08-19 | 北京泽辉辰星生物科技有限公司 | 一种多能性基因表达水平检验方法 |
| WO2023173370A1 (en) * | 2022-03-17 | 2023-09-21 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Media and methods for producing human cells and tissues from teratoma, organoids and embryoid bodies |
| CN114651787A (zh) * | 2022-04-21 | 2022-06-24 | 贵州医科大学附属医院 | 用于构建小鼠视神经特异性脱髓鞘模型的小鼠的构建方法及其应用 |
| CN117431258B (zh) * | 2023-12-20 | 2024-06-28 | 上海元戊医学技术有限公司 | 使用含有Tet1基因的重编程因子诱导人体细胞重编程的方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5489304A (en) | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
| US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| KR20040022448A (ko) | 2001-07-12 | 2004-03-12 | 제론 코포레이션 | 인간 다분화능 줄기 세포로부터 제조된 심근 세포 계통의세포 |
| EP1799810A2 (en) | 2004-10-12 | 2007-06-27 | Technion Research & Development Foundation Ltd. | Isolated primate embryonic cells and methods of generating and using same |
| WO2007113505A2 (en) | 2006-03-30 | 2007-10-11 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| AU2008236629B2 (en) | 2007-04-07 | 2014-03-06 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
| EP2090649A1 (en) | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| CN104130976A (zh) | 2008-12-17 | 2014-11-05 | 斯克里普斯研究所 | 干细胞的产生和保持 |
| WO2010124290A2 (en) * | 2009-04-24 | 2010-10-28 | Whitehead Institute For Biomedical Research | Compositions and methods for deriving or culturing pluripotent cells |
| US20130273649A1 (en) | 2012-04-13 | 2013-10-17 | University Of Southern California | Culture medium for pluripotent stem cells |
| WO2014174470A1 (en) | 2013-04-23 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
| EP3194572B1 (en) | 2014-07-30 | 2023-10-25 | Yeda Research and Development Co. Ltd. | Media for culturing pluripotent stem cells |
| EP3221446B1 (en) | 2014-11-17 | 2024-08-21 | Genome Research Limited | In vitro production of expanded potential stem cells |
-
2014
- 2014-04-23 WO PCT/IB2014/060954 patent/WO2014174470A1/en not_active Ceased
- 2014-04-23 EP EP14727237.1A patent/EP2989199B1/en active Active
- 2014-04-23 ES ES14727237T patent/ES2831424T3/es active Active
- 2014-04-23 JP JP2016509588A patent/JP2016521971A/ja active Pending
- 2014-04-23 US US14/259,997 patent/US10920192B2/en active Active
- 2014-04-23 CN CN201480035892.7A patent/CN105531365A/zh active Pending
-
2015
- 2015-10-06 IL IL241930A patent/IL241930B/en active IP Right Grant
-
2020
- 2020-12-10 US US17/117,157 patent/US20210253998A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2831424T3 (es) | 2021-06-08 |
| EP2989199B1 (en) | 2020-08-12 |
| US20140315301A1 (en) | 2014-10-23 |
| CN105531365A (zh) | 2016-04-27 |
| WO2014174470A1 (en) | 2014-10-30 |
| JP2016521971A (ja) | 2016-07-28 |
| US20210253998A1 (en) | 2021-08-19 |
| EP2989199A1 (en) | 2016-03-02 |
| US10920192B2 (en) | 2021-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL241930B (en) | Isolated naive pluripotent stem cells and methods of generating same | |
| IL284523A (en) | Methods for generating hepatocytes and cholangiocytes from multipotential gas cells | |
| IL272325B (en) | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof | |
| IL256525A (en) | Taurine supplemented cell culture medium and methods of use | |
| IL254734B1 (en) | Modified t cells and methods of making and using the same | |
| IL241286A0 (en) | Methods and materials for hematoendothelial differentiation of human pluripotential stem cells under defined conditions | |
| IL246262A0 (en) | Media for cell culture | |
| DK3702443T3 (da) | Sammensætninger og fremgangsmåder til opformering og dyrkning af epiteliale stamceller | |
| EP2971040A4 (en) | CELL CULTURE METHODS | |
| EP2971014A4 (en) | CELL CULTURE METHODS | |
| IL240855B (en) | Apparatus, method, and system for image-based human embryo cell classification | |
| EP2968611A4 (en) | IMMUNOPROTECTIVE PRIMARY MESENCHYMAL STEM CELLS AND METHOD | |
| EP3805369C0 (en) | IMPROVED REPROGRAMMING PROCESSES AND CELL CULTURE PLATFORMS | |
| EP3066193C0 (en) | CELL CULTURE PROCESS | |
| LT3064575T (lt) | Pliuripotentinių kamieninių ląstelių, indikuotų iš mezenchiminių kamieninių ląstelių, diferenciacijos į hepatocitus būdas | |
| EP2949746A4 (en) | METHOD OF SUB-CULTURE OF PLURIPOTENT STEM CELLS | |
| IL250495B (en) | Stem cell compositions and methods of producing stem cells for therapeutic applications | |
| LT3064574T (lt) | Pluripotentinių kamieninių ląstelių, indikuotų iš mezenchiminių kamieninių ląstelių, diferenciacijos į chondrocitus būdas | |
| IL245272B (en) | pif-transfected cells and methods of use | |
| FI20135341L (fi) | Menetelmä biopolttoaineen valmistamiseksi ja biopolttoaineen käyttö | |
| EP3008174A4 (en) | Method of efficiently establishing induced pluripotent stem cells | |
| DK2978839T3 (da) | Fremgangsmåde til celledyrkning | |
| SG10201800836YA (en) | Method of identifying adipose stem cells | |
| DK2970883T3 (da) | Forbedrede placenta stamceller og bruge deraf | |
| HUE046356T2 (hu) | Eljárás hematopoietikus õssejtek expandálására |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |