IL240046A0 - 3,2-dihydroimidazol[c-2,1]pyrimidine-5(h1)-one based lipoprotein-dependent phospholipase a2 (lp-pla2) inhibitors - Google Patents

3,2-dihydroimidazol[c-2,1]pyrimidine-5(h1)-one based lipoprotein-dependent phospholipase a2 (lp-pla2) inhibitors

Info

Publication number
IL240046A0
IL240046A0 IL240046A IL24004615A IL240046A0 IL 240046 A0 IL240046 A0 IL 240046A0 IL 240046 A IL240046 A IL 240046A IL 24004615 A IL24004615 A IL 24004615A IL 240046 A0 IL240046 A0 IL 240046A0
Authority
IL
Israel
Prior art keywords
dihydroimidazol
pla2
pyrimidin
inhibitors
associated phospholipase
Prior art date
Application number
IL240046A
Other languages
English (en)
Hebrew (he)
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50002724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL240046(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of IL240046A0 publication Critical patent/IL240046A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL240046A 2013-01-25 2015-07-20 3,2-dihydroimidazol[c-2,1]pyrimidine-5(h1)-one based lipoprotein-dependent phospholipase a2 (lp-pla2) inhibitors IL240046A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2013070976 2013-01-25
CN2013001556 2013-12-12
PCT/EP2014/051286 WO2014114694A1 (en) 2013-01-25 2014-01-23 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors

Publications (1)

Publication Number Publication Date
IL240046A0 true IL240046A0 (en) 2015-08-31

Family

ID=50002724

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240046A IL240046A0 (en) 2013-01-25 2015-07-20 3,2-dihydroimidazol[c-2,1]pyrimidine-5(h1)-one based lipoprotein-dependent phospholipase a2 (lp-pla2) inhibitors

Country Status (23)

Country Link
US (1) US9708330B2 (OSRAM)
EP (1) EP2948452B1 (OSRAM)
JP (1) JP6306053B2 (OSRAM)
KR (1) KR20150108897A (OSRAM)
CN (1) CN105008368B (OSRAM)
AU (1) AU2014209949B2 (OSRAM)
BR (1) BR112015017759B1 (OSRAM)
CA (1) CA2899091A1 (OSRAM)
CL (1) CL2015002060A1 (OSRAM)
CR (1) CR20150390A (OSRAM)
EA (1) EA025885B1 (OSRAM)
ES (1) ES2642762T3 (OSRAM)
HK (1) HK1216425A1 (OSRAM)
IL (1) IL240046A0 (OSRAM)
MA (1) MA38284B1 (OSRAM)
MX (1) MX2015009633A (OSRAM)
PE (1) PE20151251A1 (OSRAM)
PH (1) PH12015501586A1 (OSRAM)
SG (1) SG11201505520WA (OSRAM)
TW (1) TW201443054A (OSRAM)
UY (1) UY35276A (OSRAM)
WO (1) WO2014114694A1 (OSRAM)
ZA (1) ZA201505025B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20151251A1 (es) 2013-01-25 2015-09-10 Glaxosmithkline Ip Dev Ltd Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2
KR20170034889A (ko) 2014-07-22 2017-03-29 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화합물
WO2016012916A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN104892459A (zh) * 2015-06-16 2015-09-09 苏州明锐医药科技有限公司 利奥西呱中间体及其制备方法
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
JP7564872B2 (ja) * 2019-11-09 2024-10-09 シャンハイ エスアイエムアール バイオテクノロジー カンパニー リミテッド 三環式ジヒドロイミダゾピリミドン誘導体、その調製方法、その医薬組成物及び使用
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
CN113861220B (zh) * 2020-06-30 2023-06-16 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
KR20250055539A (ko) * 2022-08-04 2025-04-24 4비 테크놀로지스 (베이징) 컴퍼니 리미티드 Lp-pla2 억제제로서의 디하이드로이미다조-피리미디논 화합물 및 이의 용도
CN116925023B (zh) * 2023-07-18 2025-11-21 江苏桐孚高新材料有限公司 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法

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KR20140059203A (ko) * 2011-07-27 2014-05-15 글락소 그룹 리미티드 2,3-디히드로이미다조[1,2-c]피리미딘-5(1h)-온 화합물의 lp-pla2 억제제로서의 용도
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PE20151251A1 (es) 2013-01-25 2015-09-10 Glaxosmithkline Ip Dev Ltd Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2

Also Published As

Publication number Publication date
AU2014209949B2 (en) 2016-09-08
EP2948452B1 (en) 2017-08-09
US9708330B2 (en) 2017-07-18
US20150361082A1 (en) 2015-12-17
BR112015017759A2 (pt) 2017-07-11
MX2015009633A (es) 2015-11-30
UY35276A (es) 2014-08-29
ES2642762T3 (es) 2017-11-20
AU2014209949A1 (en) 2015-07-30
CL2015002060A1 (es) 2015-11-27
EA201591379A1 (ru) 2016-01-29
SG11201505520WA (en) 2015-08-28
CN105008368A (zh) 2015-10-28
HK1216425A1 (zh) 2016-11-11
CR20150390A (es) 2015-10-19
EP2948452A1 (en) 2015-12-02
BR112015017759B1 (pt) 2022-05-24
EA025885B1 (ru) 2017-02-28
PH12015501586A1 (en) 2015-10-05
MA38284A1 (fr) 2017-12-29
ZA201505025B (en) 2017-08-30
JP2016505058A (ja) 2016-02-18
TW201443054A (zh) 2014-11-16
WO2014114694A1 (en) 2014-07-31
MA38284B1 (fr) 2018-05-31
CA2899091A1 (en) 2014-07-31
CN105008368B (zh) 2017-02-01
PE20151251A1 (es) 2015-09-10
JP6306053B2 (ja) 2018-04-04
KR20150108897A (ko) 2015-09-30

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