IL126696A0 - Azetidinone derivatives for the treatment of atherosclerosis - Google Patents
Azetidinone derivatives for the treatment of atherosclerosisInfo
- Publication number
- IL126696A0 IL126696A0 IL12669697A IL12669697A IL126696A0 IL 126696 A0 IL126696 A0 IL 126696A0 IL 12669697 A IL12669697 A IL 12669697A IL 12669697 A IL12669697 A IL 12669697A IL 126696 A0 IL126696 A0 IL 126696A0
- Authority
- IL
- Israel
- Prior art keywords
- atherosclerosis
- treatment
- azetidinone derivatives
- azetidinone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9608646.7A GB9608646D0 (en) | 1996-04-26 | 1996-04-26 | Novel compounds |
GBGB9623756.5A GB9623756D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
GBGB9625121.0A GB9625121D0 (en) | 1996-12-03 | 1996-12-03 | Novel compounds |
PCT/EP1997/001898 WO1997041098A1 (en) | 1996-04-26 | 1997-04-15 | Azetidinone derivatives for the treatment of atherosclerosis |
Publications (1)
Publication Number | Publication Date |
---|---|
IL126696A0 true IL126696A0 (en) | 1999-08-17 |
Family
ID=27268259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12669697A IL126696A0 (en) | 1996-04-26 | 1997-04-15 | Azetidinone derivatives for the treatment of atherosclerosis |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0915843A1 (en) |
JP (1) | JP2000509049A (en) |
AR (1) | AR006833A1 (en) |
AU (1) | AU2698697A (en) |
BR (1) | BR9709196A (en) |
CA (1) | CA2252696A1 (en) |
CZ (1) | CZ341098A3 (en) |
HU (1) | HUP9901359A3 (en) |
ID (1) | ID16660A (en) |
IL (1) | IL126696A0 (en) |
MA (1) | MA26426A1 (en) |
NO (1) | NO984939L (en) |
NZ (1) | NZ332476A (en) |
PE (1) | PE64398A1 (en) |
PL (1) | PL329530A1 (en) |
TR (1) | TR199802160T2 (en) |
WO (1) | WO1997041098A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ304450B6 (en) | 2000-02-16 | 2014-05-14 | Smithkline Beecham P. L. C. | Pyrimidine derivative |
AU2002258605B2 (en) | 2001-03-28 | 2006-01-12 | Merck Sharp & Dohme Corp. | Enantioselective synthesis of azetidinone intermediate compounds |
US20030013699A1 (en) * | 2001-05-25 | 2003-01-16 | Davis Harry R. | Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject |
EA018101B1 (en) | 2007-05-11 | 2013-05-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Methods of treatment of skin ulcers |
US8962633B2 (en) | 2007-05-11 | 2015-02-24 | Thomas Jefferson University | Methods of treatment and prevention of metabolic bone diseases and disorders |
EP2152865B1 (en) | 2007-05-11 | 2015-04-15 | Thomas Jefferson University | Methods of treatment and prevention of neurodegenerative diseases and disorders |
CA2820408C (en) | 2010-12-06 | 2018-03-06 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2 |
EP2651403B1 (en) | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases |
US20140171431A1 (en) | 2011-06-27 | 2014-06-19 | Jianhua Shen | Azole heterocyclic compound, preparation method, pharmaceutical composition and use |
CA2843102A1 (en) | 2011-07-27 | 2013-01-31 | Glaxo Group Limited | Bicyclic pyrimidone compounds |
KR20140059203A (en) | 2011-07-27 | 2014-05-15 | 글락소 그룹 리미티드 | 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors |
BR112015017397A2 (en) | 2013-01-25 | 2017-07-11 | Glaxosmithkline Ip Dev Ltd | bicyclic pyrimidone compounds as lp-pla2 inhibitors |
CN105008368B (en) | 2013-01-25 | 2017-02-01 | 葛兰素史密斯克莱知识产权发展有限公司 | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors |
CN105008365B (en) | 2013-01-25 | 2017-03-15 | 葛兰素史密斯克莱知识产权发展有限公司 | Compound |
WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
CA3156783A1 (en) | 2019-11-09 | 2021-05-14 | Yun Jin | Tricycle dihydroimidazopyrimidone derivative, preparation method thereof, pharmaceutical composition and use thereof |
CN115304620A (en) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | Pyrimidone derivatives, preparation method, pharmaceutical composition and application thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
IL89835A0 (en) * | 1988-04-11 | 1989-12-15 | Merck & Co Inc | Substituted azetidinones,their preparation and pharmaceutical compositions containing them |
IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
WO1993000332A1 (en) * | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
MY131273A (en) * | 1991-07-23 | 2007-07-31 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
CA2108584C (en) * | 1992-10-27 | 1998-11-24 | James B. Doherty | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
AU5802894A (en) * | 1992-12-17 | 1994-07-04 | Merck & Co., Inc. | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
WO1995000649A1 (en) * | 1993-06-25 | 1995-01-05 | Smithkline Beecham Plc | Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy |
ATE201905T1 (en) * | 1993-10-06 | 2001-06-15 | Icos Corp | PLATELE ACTIVATE FACTOR ACETHYL HYDROLASE |
GB9421816D0 (en) * | 1994-10-29 | 1994-12-14 | Smithkline Beecham Plc | Novel compounds |
CA2208530A1 (en) * | 1994-12-22 | 1996-06-27 | Smithkline Beecham P.L.C. | Substituted azetidin-2-ones for treatment of atherosclerosis |
AU5014496A (en) * | 1995-03-23 | 1996-10-08 | Japan Tobacco Inc. | Diphenylmethyl-azetidinone compounds and elastase inhibitor |
SK178497A3 (en) * | 1995-07-01 | 1998-07-08 | Smithkline Beecham Plc | Azetidinone derivatives, method for producing the same, pharmaceutical composition containing same and their use |
WO1997021676A1 (en) * | 1995-12-08 | 1997-06-19 | Smithkline Beecham Plc | Azetidinone compounds for the treatment of atherosclerosis |
-
1997
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 IL IL12669697A patent/IL126696A0/en unknown
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/en unknown
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Application Discontinuation
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/en unknown
- 1997-04-15 PL PL97329530A patent/PL329530A1/en unknown
- 1997-04-15 BR BR9709196A patent/BR9709196A/en not_active Application Discontinuation
- 1997-04-15 JP JP9538507A patent/JP2000509049A/en active Pending
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/en unknown
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-24 AR ARP970101682A patent/AR006833A1/en unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/en not_active Application Discontinuation
- 1997-04-24 MA MA24565A patent/MA26426A1/en unknown
- 1997-04-25 ID IDP971394A patent/ID16660A/en unknown
-
1998
- 1998-10-23 NO NO984939A patent/NO984939L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2000509049A (en) | 2000-07-18 |
AU2698697A (en) | 1997-11-19 |
WO1997041098A1 (en) | 1997-11-06 |
NO984939L (en) | 1998-12-23 |
CZ341098A3 (en) | 1999-03-17 |
CA2252696A1 (en) | 1997-11-06 |
HUP9901359A3 (en) | 2000-03-28 |
BR9709196A (en) | 1999-05-25 |
PL329530A1 (en) | 1999-03-29 |
PE64398A1 (en) | 1999-01-06 |
NO984939D0 (en) | 1998-10-23 |
MA26426A1 (en) | 2004-12-20 |
EP0915843A1 (en) | 1999-05-19 |
HUP9901359A2 (en) | 1999-08-30 |
AR006833A1 (en) | 1999-09-29 |
NZ332476A (en) | 2000-06-23 |
ID16660A (en) | 1997-10-30 |
TR199802160T2 (en) | 1999-04-21 |
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