IL236711B - Process for preparing 17-disubstituted derivatives of 3-methoxy-6-oxo-8,7-didhydro-14-hydroxy-morphinan sulfates - Google Patents
Process for preparing 17-disubstituted derivatives of 3-methoxy-6-oxo-8,7-didhydro-14-hydroxy-morphinan sulfatesInfo
- Publication number
- IL236711B IL236711B IL236711A IL23671115A IL236711B IL 236711 B IL236711 B IL 236711B IL 236711 A IL236711 A IL 236711A IL 23671115 A IL23671115 A IL 23671115A IL 236711 B IL236711 B IL 236711B
- Authority
- IL
- Israel
- Prior art keywords
- morphinan
- didehydro
- sulfates
- oxo
- methoxy
- Prior art date
Links
- -1 3-methoxy-6-oxo-7,8-didehydro-14-hydroxy-17-substituted-morphinan sulfates Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672265P | 2012-07-16 | 2012-07-16 | |
| US201361762657P | 2013-02-08 | 2013-02-08 | |
| PCT/IB2013/001538 WO2014013311A1 (en) | 2012-07-16 | 2013-07-15 | Process for improved opioid synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL236711A0 IL236711A0 (en) | 2015-02-26 |
| IL236711B true IL236711B (en) | 2018-04-30 |
Family
ID=48916126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL236711A IL236711B (en) | 2012-07-16 | 2015-01-13 | Process for preparing 17-disubstituted derivatives of 3-methoxy-6-oxo-8,7-didhydro-14-hydroxy-morphinan sulfates |
Country Status (21)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101946104B1 (ko) | 2012-07-16 | 2019-02-08 | 로드스 테크놀로지즈 | 개선된 오피오이드 합성을 위한 방법 |
| BR112015000944A2 (pt) | 2012-07-16 | 2019-10-15 | Rhodes Tech | processo para síntese melhorada de opioide |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| CN106164078A (zh) * | 2013-12-18 | 2016-11-23 | 科迪实验室公司 | 氧可酮盐酸盐的合成 |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| MX379406B (es) | 2014-01-15 | 2025-03-11 | Rhodes Tech | Proceso para la síntesis mejorada de oximorfona. |
| JP2017502991A (ja) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | 改良されたオキシコドン合成のための方法 |
| US20160052932A1 (en) | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
| CN110770238B (zh) | 2017-06-20 | 2022-10-04 | 庄信万丰股份有限公司 | 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法 |
| KR102445512B1 (ko) | 2018-03-30 | 2022-09-21 | 삼성디스플레이 주식회사 | 지문 센서 패키지 및 이를 포함하는 표시 장치 |
| KR102120720B1 (ko) * | 2018-07-16 | 2020-06-10 | 연성정밀화학(주) | 날푸라핀 함유 구강붕해정 |
| CN114573508B (zh) * | 2020-12-01 | 2024-07-23 | 绍兴赜军生物医药科技有限公司 | 羟考酮类化合物、其中间体及制备方法 |
| US11247999B1 (en) | 2021-07-02 | 2022-02-15 | Joseph DeGraw | Facile conversion of morphine to normorphine |
| CN114276358B (zh) * | 2022-01-07 | 2023-09-12 | 北京华素制药股份有限公司 | 羟考酮盐酸盐的多晶型物及其制备方法和用途 |
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| US2772270A (en) | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
| US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1960-11-29 | |||
| US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-11-02 | 1969-05-06 | ||
| US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
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| TW201509943A (zh) * | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
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| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| ES2659168T3 (es) * | 2010-07-02 | 2018-03-14 | Johnson Matthey Public Limited Company | Proceso para la síntesis y purificación de oxicodona |
| JP5728084B2 (ja) | 2010-07-08 | 2015-06-03 | アルカーメス ファーマ アイルランド リミテッド | 置換モルフィナンの合成のための方法 |
| JP5780933B2 (ja) | 2010-12-01 | 2015-09-16 | 高砂香料工業株式会社 | 光学活性メントールの製造方法 |
| US9657029B2 (en) | 2012-06-11 | 2017-05-23 | Siegfried Generics International Ag | Method of preparing oxymorphone |
| KR101946104B1 (ko) | 2012-07-16 | 2019-02-08 | 로드스 테크놀로지즈 | 개선된 오피오이드 합성을 위한 방법 |
| BR112015000944A2 (pt) | 2012-07-16 | 2019-10-15 | Rhodes Tech | processo para síntese melhorada de opioide |
| CN103113378B (zh) | 2013-02-20 | 2016-04-06 | 北京华素制药股份有限公司 | 一种盐酸羟吗啡酮的合成方法 |
| CN103433076B (zh) | 2013-09-02 | 2015-06-24 | 浙江新和成股份有限公司 | 一种固载型不对称催化剂及其在不对称氢化反应中的应用 |
| US9060620B1 (en) | 2013-12-04 | 2015-06-23 | Yogi Realty LLC | Baby restraining article |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| CN106164078A (zh) | 2013-12-18 | 2016-11-23 | 科迪实验室公司 | 氧可酮盐酸盐的合成 |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| MX379406B (es) | 2014-01-15 | 2025-03-11 | Rhodes Tech | Proceso para la síntesis mejorada de oximorfona. |
| JP2017502991A (ja) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | 改良されたオキシコドン合成のための方法 |
-
2013
- 2013-07-15 KR KR1020157003909A patent/KR101946104B1/ko active Active
- 2013-07-15 SG SG11201407986QA patent/SG11201407986QA/en unknown
- 2013-07-15 CA CA2879268A patent/CA2879268C/en active Active
- 2013-07-15 ES ES13745177.9T patent/ES2638178T3/es active Active
- 2013-07-15 AU AU2013291723A patent/AU2013291723B2/en active Active
- 2013-07-15 MX MX2015000880A patent/MX362186B/es active IP Right Grant
- 2013-07-15 AR ARP130102526 patent/AR091779A1/es unknown
- 2013-07-15 EA EA201590221A patent/EA029925B1/ru not_active IP Right Cessation
- 2013-07-15 BR BR112015000867A patent/BR112015000867A2/pt not_active Application Discontinuation
- 2013-07-15 WO PCT/IB2013/001538 patent/WO2014013311A1/en active Application Filing
- 2013-07-15 US US14/413,360 patent/US20150259355A1/en not_active Abandoned
- 2013-07-15 TW TW102125209A patent/TWI588147B/zh active
- 2013-07-15 TW TW105112605A patent/TW201639855A/zh unknown
- 2013-07-15 UA UAA201501304A patent/UA117226C2/uk unknown
- 2013-07-15 JP JP2015522181A patent/JP6236446B2/ja active Active
- 2013-07-15 CN CN201380037927.6A patent/CN104507947B/zh active Active
- 2013-07-15 NZ NZ628695A patent/NZ628695A/en unknown
- 2013-07-15 EP EP13745177.9A patent/EP2877473B1/en active Active
- 2013-07-15 NZ NZ715111A patent/NZ715111A/en unknown
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2015
- 2015-01-13 IL IL236711A patent/IL236711B/en active IP Right Grant
- 2015-01-14 PH PH12015500088A patent/PH12015500088A1/en unknown
- 2015-01-29 CO CO15018246A patent/CO7180189A2/es unknown
- 2015-02-12 IN IN1164DEN2015 patent/IN2015DN01164A/en unknown
-
2016
- 2016-07-14 AU AU2016204929A patent/AU2016204929A1/en not_active Abandoned
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2017
- 2017-09-11 US US15/700,345 patent/US10202396B2/en active Active
-
2019
- 2019-02-08 US US16/270,969 patent/US20190308986A1/en not_active Abandoned
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2020
- 2020-09-08 US US17/014,134 patent/US11390627B2/en active Active
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| FF | Patent granted | ||
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