IL235978B - Oligonucleotide synthesis method utilizing liquid support in high dispersive phase - Google Patents
Oligonucleotide synthesis method utilizing liquid support in high dispersive phaseInfo
- Publication number
- IL235978B IL235978B IL235978A IL23597814A IL235978B IL 235978 B IL235978 B IL 235978B IL 235978 A IL235978 A IL 235978A IL 23597814 A IL23597814 A IL 23597814A IL 235978 B IL235978 B IL 235978B
- Authority
- IL
- Israel
- Prior art keywords
- synthesis method
- oligonucleotide synthesis
- phase support
- highly dispersible
- dispersible liquid
- Prior art date
Links
- 239000007791 liquid phase Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2012/063921 WO2013179412A1 (ja) | 2012-05-30 | 2012-05-30 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL235978A0 IL235978A0 (en) | 2015-02-01 |
| IL235978B true IL235978B (en) | 2018-02-28 |
Family
ID=49672666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL235978A IL235978B (en) | 2012-05-30 | 2014-11-27 | Oligonucleotide synthesis method utilizing liquid support in high dispersive phase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9284344B2 (forum.php) |
| EP (1) | EP2857412B1 (forum.php) |
| DK (1) | DK2857412T3 (forum.php) |
| IL (1) | IL235978B (forum.php) |
| IN (1) | IN2014DN10144A (forum.php) |
| SG (1) | SG11201407967TA (forum.php) |
| WO (1) | WO2013179412A1 (forum.php) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| SG177564A1 (en) | 2009-07-06 | 2012-02-28 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| KR20140068884A (ko) | 2011-07-19 | 2014-06-09 | 웨이브 라이프 사이언시스 피티이. 리미티드 | 관능화된 핵산의 합성 방법 |
| CN106977567B (zh) * | 2012-02-17 | 2021-02-02 | 味之素株式会社 | 碱基部保护寡核苷酸 |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| PL2872147T3 (pl) | 2012-07-13 | 2023-09-25 | Wave Life Sciences Ltd. | Sposób wytwarzania chiralnych oligonukleotydów |
| CN104684893B (zh) | 2012-07-13 | 2016-10-26 | 日本波涛生命科学公司 | 不对称辅助基团 |
| AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| TWI729028B (zh) | 2015-11-17 | 2021-06-01 | 日商日產化學工業股份有限公司 | 寡核苷酸的製造方法 |
| WO2017104836A1 (ja) * | 2015-12-16 | 2017-06-22 | 味の素株式会社 | オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド |
| JPWO2017111137A1 (ja) * | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| CN113423715A (zh) | 2019-02-15 | 2021-09-21 | 味之素株式会社 | 寡核苷酸的制造方法 |
| JP7628073B2 (ja) | 2019-02-28 | 2025-02-07 | 富士フイルム株式会社 | ペプチド化合物の製造方法、保護基形成用試薬、及び、芳香族複素環化合物 |
| WO2020196890A1 (ja) | 2019-03-28 | 2020-10-01 | 味の素株式会社 | ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法 |
| CN114206897B (zh) * | 2019-05-08 | 2024-09-20 | 比奥根Ma公司 | 寡核苷酸的汇聚液相合成 |
| WO2021039935A1 (ja) * | 2019-08-29 | 2021-03-04 | 富士フイルム株式会社 | 核酸化合物の製造方法、及び、核酸化合物 |
| EP4126894A1 (en) | 2020-03-31 | 2023-02-08 | Janssen BioPharma, Inc. | Synthesis of oligonucleotides and related compounds |
| FR3111896A1 (fr) * | 2020-06-24 | 2021-12-31 | Strainchem | Procédés de synthèses en solution de macromolécules à partir d’unités de dérivés de glucides |
| CN113583069B (zh) * | 2021-09-09 | 2023-06-06 | 北京大学 | 核苷磷脂类化合物及其化学合成方法和在核酸递送中的应用 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| US12180140B2 (en) | 2022-12-23 | 2024-12-31 | Hongene Biotech Corporation | Compounds and methods for liquid phase oligonucleotide synthesis |
| WO2025082632A1 (en) | 2023-10-16 | 2025-04-24 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
| JP2003002895A (ja) * | 2001-05-30 | 2003-01-08 | Tokyo Inst Of Technol | 核酸の合成法 |
| JP4963665B2 (ja) | 2007-11-27 | 2012-06-27 | 株式会社ミツバ | 扁平型コミュテータ及びその製造方法 |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| CN103476784B (zh) | 2011-05-17 | 2017-05-24 | 味之素株式会社 | 制备寡核苷酸的方法 |
| CN106977567B (zh) * | 2012-02-17 | 2021-02-02 | 味之素株式会社 | 碱基部保护寡核苷酸 |
-
2012
- 2012-05-30 WO PCT/JP2012/063921 patent/WO2013179412A1/ja active Application Filing
- 2012-05-30 US US14/404,562 patent/US9284344B2/en active Active
- 2012-05-30 DK DK12877844.6T patent/DK2857412T3/en active
- 2012-05-30 IN IN10144DEN2014 patent/IN2014DN10144A/en unknown
- 2012-05-30 SG SG11201407967TA patent/SG11201407967TA/en unknown
- 2012-05-30 EP EP12877844.6A patent/EP2857412B1/en active Active
-
2014
- 2014-11-27 IL IL235978A patent/IL235978B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201407967TA (en) | 2015-01-29 |
| IN2014DN10144A (forum.php) | 2015-08-21 |
| EP2857412A1 (en) | 2015-04-08 |
| US9284344B2 (en) | 2016-03-15 |
| IL235978A0 (en) | 2015-02-01 |
| WO2013179412A1 (ja) | 2013-12-05 |
| DK2857412T3 (en) | 2017-04-03 |
| US20150112053A1 (en) | 2015-04-23 |
| EP2857412B1 (en) | 2017-01-11 |
| EP2857412A4 (en) | 2015-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |