IN2014DN10144A - - Google Patents
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- Publication number
- IN2014DN10144A IN2014DN10144A IN10144DEN2014A IN2014DN10144A IN 2014DN10144 A IN2014DN10144 A IN 2014DN10144A IN 10144DEN2014 A IN10144DEN2014 A IN 10144DEN2014A IN 2014DN10144 A IN2014DN10144 A IN 2014DN10144A
- Authority
- IN
- India
- Prior art keywords
- hydrophobic
- nucleoside
- group
- complex compound
- bound
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 6
- 239000002777 nucleoside Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- -1 nucleoside phosphoramidite compound Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 238000001668 nucleic acid synthesis Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Provided is a nucleic acid synthesis method in which a highly dispersible liquid phase support is used , a reaction can proceed in a fluid (flow), and the coupling efficiency is improved. A method for synthesizing an oligonucleotide , which comprises a step of condensing and then oxidizing a nucleoside phosphoramidite compound in the presence of an acid azole complex compound using a hydrophobic -group- bound nucleoside represented by general formula (1) as a starting material , wherein the condensation reaction is carried out by dissolving the hydrophobic group bound nucleoside or a hydrophobic- group- bound oligonucleotide and a nucleoside phosphoramidite compound in a non -polar solvent in advance and then bringing the resultant solution into contact with an acid azole complex compound or a solution containing the acid azole complex compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2012/063921 WO2013179412A1 (en) | 2012-05-30 | 2012-05-30 | Oligonucleotide synthesis method using highly dispersible liquid-phase support |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10144A true IN2014DN10144A (en) | 2015-08-21 |
Family
ID=49672666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10144DEN2014 IN2014DN10144A (en) | 2012-05-30 | 2012-05-30 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9284344B2 (en) |
| EP (1) | EP2857412B1 (en) |
| DK (1) | DK2857412T3 (en) |
| IL (1) | IL235978B (en) |
| IN (1) | IN2014DN10144A (en) |
| SG (1) | SG11201407967TA (en) |
| WO (1) | WO2013179412A1 (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102282155B (en) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | The synthetic method of the nucleic acid of phosphorus atoms modification |
| KR101885383B1 (en) | 2009-07-06 | 2018-08-03 | 웨이브 라이프 사이언시스 리미티드 | Novel nucleic acid prodrugs and methods of use thereof |
| WO2012039448A1 (en) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | Asymmetric auxiliary group |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| WO2013122236A1 (en) * | 2012-02-17 | 2013-08-22 | 味の素株式会社 | Base-protected oligonucleotide |
| SG10201912895PA (en) | 2012-07-13 | 2020-02-27 | Wave Life Sciences Ltd | Chiral control |
| KR101835401B1 (en) | 2012-07-13 | 2018-03-08 | 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. | Chiral nucleic acid adjuvant |
| AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| JPWO2015108046A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant and antiallergic agent having antiallergic action |
| WO2015108047A1 (en) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| JP6382344B2 (en) | 2014-01-16 | 2018-08-29 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | Chiral design |
| WO2017086397A1 (en) | 2015-11-17 | 2017-05-26 | 日産化学工業株式会社 | Method for producing oligonucleotide |
| WO2017104836A1 (en) | 2015-12-16 | 2017-06-22 | 味の素株式会社 | Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide |
| JPWO2017111137A1 (en) * | 2015-12-22 | 2018-10-18 | 味の素株式会社 | Method for producing oligonucleotide |
| EP3925964A4 (en) | 2019-02-15 | 2022-12-07 | Ajinomoto Co., Inc. | Production method for oligonucleotides |
| JP7628073B2 (en) | 2019-02-28 | 2025-02-07 | 富士フイルム株式会社 | Method for producing peptide compound, reagent for forming protecting group, and aromatic heterocyclic compound |
| EP3950698A4 (en) | 2019-03-28 | 2023-01-25 | Ajinomoto Co., Inc. | Method for producing oligonucleotide having phosphorothioate site |
| CN119462804A (en) * | 2019-05-08 | 2025-02-18 | 渤健马萨诸塞州股份有限公司 | Convergent Liquid Phase Synthesis of Oligonucleotides |
| WO2021039935A1 (en) * | 2019-08-29 | 2021-03-04 | 富士フイルム株式会社 | Nucleic acid compound manufacturing method and nucleic acid compound |
| CN115843299A (en) | 2020-03-31 | 2023-03-24 | 詹森生物制药有限公司 | Synthesis of oligonucleotides and related compounds |
| FR3111896A1 (en) | 2020-06-24 | 2021-12-31 | Strainchem | Synthesis processes in solution of macromolecules from units of carbohydrate derivatives |
| CN113583069B (en) * | 2021-09-09 | 2023-06-06 | 北京大学 | Nucleoside phospholipid compound and its chemical synthesis method and application in nucleic acid delivery |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| WO2024137756A1 (en) * | 2022-12-23 | 2024-06-27 | Hongene Biotech Corporation | Compounds and methods for liquid phase oligonucleotide synthesis |
| WO2025082632A1 (en) | 2023-10-16 | 2025-04-24 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
| JP2003002895A (en) | 2001-05-30 | 2003-01-08 | Tokyo Inst Of Technol | Nucleic acid synthesis |
| JP4963665B2 (en) | 2007-11-27 | 2012-06-27 | 株式会社ミツバ | Flat type commutator and manufacturing method thereof |
| JP5548852B2 (en) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | Hydrophobic group-bonded nucleoside, hydrophobic group-bonded nucleoside solution, and hydrophobic group-bonded oligonucleotide synthesis method |
| EP2711370B1 (en) * | 2011-05-17 | 2018-01-03 | Ajinomoto Co., Inc. | Method for producing oligonucleotides |
| WO2013122236A1 (en) * | 2012-02-17 | 2013-08-22 | 味の素株式会社 | Base-protected oligonucleotide |
-
2012
- 2012-05-30 US US14/404,562 patent/US9284344B2/en active Active
- 2012-05-30 EP EP12877844.6A patent/EP2857412B1/en active Active
- 2012-05-30 SG SG11201407967TA patent/SG11201407967TA/en unknown
- 2012-05-30 DK DK12877844.6T patent/DK2857412T3/en active
- 2012-05-30 WO PCT/JP2012/063921 patent/WO2013179412A1/en active Application Filing
- 2012-05-30 IN IN10144DEN2014 patent/IN2014DN10144A/en unknown
-
2014
- 2014-11-27 IL IL235978A patent/IL235978B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201407967TA (en) | 2015-01-29 |
| WO2013179412A1 (en) | 2013-12-05 |
| DK2857412T3 (en) | 2017-04-03 |
| US20150112053A1 (en) | 2015-04-23 |
| IL235978B (en) | 2018-02-28 |
| US9284344B2 (en) | 2016-03-15 |
| IL235978A0 (en) | 2015-02-01 |
| EP2857412A1 (en) | 2015-04-08 |
| EP2857412A4 (en) | 2015-10-21 |
| EP2857412B1 (en) | 2017-01-11 |
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